Conserved Protein Domain Family
7tmA_OR4-like

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cd15226: 7tmA_OR4-like 
olfactory receptor family 4 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors
This group includes human olfactory receptor family 4 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.
Statistics
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PSSM-Id: 320354
Aligned: 38 rows
Threshold Bit Score: 379.625
Created: 4-Dec-2013
Updated: 17-Oct-2022
Structure
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Aligned Rows:
  next features
Feature 1:putative ligand binding pocket [chemical binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                #  ##           ###### #
Q8NGF8        23 SVCFVVFLPVYLATVVGNGLIVLTVSISKSLdsPMYFFLSCLSLVEISYSSTIAPKFIIDLLakIKTISLeGCLTQIFFF 102 human
Q8NGB8        25 LLLFVFSLLFYFASMMGNLVIVFTVTMDAHLhsPMYFLLANLSIIDMAFCSITAPKMICDIFkkHKAISFrGCITQIFFS 104 human
NP_001000607  25 IFLFFFSCLFYVSSLTGNFIIVVTVTSDPYLhsPMYFLLANLSVIDLIFCSIAAPKMICDLFrkQKVISFgGCISQVFFS 104 Norway rat
Q8NGB9        25 LLLFLFFSVFYVSSLMGNLLIVLTVTSDPRLqsPMYFLLANLSIINLVFCSSTAPKMIYDLFrkHKTISFgGCVVQIFFI 104 human
NP_001000365  25 HFFLAFSMVLYVAIVLGNTLVVFTLAFDQHLhsPMYFLLGNLSFIDLCLSTLTVPKMISDLSsgHNTISFhSCVFQIFVL 104 Norway rat
Q6IEY1        25 LLLLVFSSVLYVASITGNILIVFSVTTDPHLhsPMYFLLASLSFIDLGACSVTSPKMIYDLFrkRKVISFgGCIAQIFFI 104 human
NP_001000369  25 IFFGLLFSLFYVGILFGNLFIVFIVIFDSHLhsPMYILLANLSLIDLGLSSTTIPRTISDIFtgCKVISFhSCMIQMFFI 104 Norway rat
NP_001000367  25 VFLMVTFSMLYIGIILGNLFIVILVIADSHLhsPMYFLLANLSLNDVWVSSTTVPKMISDLLkeHKVISFhNCMSQICFI 104 Norway rat
XP_007655822   8 HLLFVLFSVFYMAIVLGNSLIVLTVVADPRLhsPMYFLLANLSFFDICVSSTVTPKMIYDTLrdSKIISFgGCFAQMIFI 87  platypus
XP_004609807  35 LFLFFFPCVFHVSSMMRNFVIVITVTFDPYL--HSYFLLANLSSIDPIFCSIATPKTICDDFr-KQKXSFgHCIAQIFFS 111 European shrew
Feature 1        #  #                                            # #####                         
Q8NGF8       103 HFFGVAEILLIVVMAYDCYVAICKPLhYMNIIsRQLCHLLVAGSWLGGFCHSIIQILVIiqLPFCGPNVIDHYFCDLQPL 182 human
Q8NGB8       105 HALGGTEMVLLIAMAFDRYMAICKPLhYLTIMsPRMCLYFLATSSIIGLIHSLVQLVFVvdLPFCGPNIFDSFYCDLPRL 184 human
NP_001000607 105 HAVGGTEMVLLIAMAFDRYVAICKPLhYLSIMsPRMCLLILVAAWIIGLIHSSTQLAFVinLPFCGPNILDSFYCDIPRL 184 Norway rat
Q8NGB9       105 HAVGGTEMVLLIAMAFDRYVAICKPLhYLTIMnPQRCILFLVISWIIGIIHSVIQLAFVvdLLFCGPNELDSFFCDLPRF 184 human
NP_001000365 105 HVLGASEMVLLVAMAWDRYVAICKPLhYLTIMnPRMCLLLLSGAWIIGFLHSVAQLGFVvhLRFCGPNEIDSFYCDLPRF 184 Norway rat
Q6IEY1       105 HVVGGVEMVLLIAMAFDRYVALCKPLhYLTIMsPRMCLSFLAVAWTLGVSHSLFQLAFLvnLAFCGPNVLDSFYCDLPRL 184 human
NP_001000369 105 HVMGGVEMVLLIAMAYDRYIAICKPLhYLMIMnPKTCIILVVAAWVIGMIHAVSQFMFVinLPFCAPYNVGSFYCDFPRV 184 Norway rat
NP_001000367 105 HIMGGVEMVLLIAMAFDRYIAICKPLrYLSIMsPRICISFVIAGWVTGVIHALSQFSFVvnLPFCGPNKVDSFYCDFPRI 184 Norway rat
XP_007655822  88 HIVGGSEMVLLVAMAYDRYVAICRPLhYVAIVtLRMCIWIVVAAWIIGLIHAMSQAAFVvnLPFCGPNEVDSFFCDFPRI 167 platypus
XP_004609807 112 HAVGGSEMVLLIAMAFDRXVATCKPFhYLTIMxLCMYTLIFEVAWTIGVIHSLTSIAFLviLPFCGSNILDSFFXDTPWQ 191 European shrew
Feature 1                  #  ### ### ##                                           #  ## ##  #   
Q8NGF8       183 FKLACtdtfmEGVIVLANSGLFSVFSFLILVSSYIVILVNLrnhsaEGRHKALSTCASHITVVILFFGPAIFLYMRPssT 262 human
Q8NGB8       185 LRLACtntqeLEFMVTVNSGLISVGSFVLLVISYIFILFTVwkhssGGLAKALSTLSAHVTVVILFFGPLMFFYTWPspT 264 human
NP_001000607 185 IKLACtdtykLEFMIAANSGFISLIAFFLLIISYVFLLNTVqkqssGCSSKALSTLLAHIIVVVLFFGPLIFFYVWPapS 264 Norway rat
Q8NGB9       185 IKLACietytLGFMVTANSGFISLASFLILIISYIFILVTVqkkssGGIFKAFSMLSAHVIVVVLVFGPLIFFYIFPfpT 264 human
NP_001000365 185 IKLACmdnyrMEFMVAANSGIISIGTFFLLIISYIVILLTVrkhssGDLSKALSTLSAHISVVVLFFGPCIFVYMWPfpT 264 Norway rat
Q6IEY1       185 LRLACtdtyrLQFMVTVNSGFICVGTFFILLISYVFILFTVwkhssGGSSKALSTLSAHSTVVLLFFGPPMFVYTRPhpN 264 human
NP_001000369 185 IKLACmdtykLEFVVSANSGFISMCTFFFLITSYIFILVNVrqhssTDLSKAFFTLSAHITVVVLFFIPCMFLYVWPfpT 264 Norway rat
NP_001000367 185 IQLACtdgdkFEFVVAANSGFMSMGTFFLLLLSYVFILVTVwqrssGDLSKALVTLSAHITVVVLFFTPCMFLYVWPfpT 264 Norway rat
XP_007655822 168 IQLACtdtywLELMVTANSGFISMGTFLLLIFSYVFILVSVrkrssVGLSKAFSTLSAHISVVVLFFGPCIFVYIWPfpK 247 platypus
XP_004609807 192 MKLPCtntykLQLMVTSNSRFISLGAFFMLILSYIFILVTVqkhlsDSFSKALSTLXAHIILVIYFGPLIFFYVCFLlqH 271 European shrew
Feature 1        ## ###  #  ##              
Q8NGF8       263 FTEDKLVAVFYTVITPMLNPIIYTLRN 289 human
Q8NGB8       265 SHLDKYLAIFDAFITPFLNPVIYTFRN 291 human
NP_001000607 265 THVDKFLAIFDAVLTPFLNPVIYTLRN 291 Norway rat
Q8NGB9       265 SHLDKFLAIFDAVITPVLNPVIYTFRN 291 human
NP_001000365 265 VPVDKFLAILDFMITPILNPAIYTLRN 291 Norway rat
Q6IEY1       265 SQMDKFLAIFDAVLTPFLNPVVYTFRN 291 human
NP_001000369 265 KSLDNFFAIVDFVLTPILNPTIYTLRN 291 Norway rat
NP_001000367 265 SSIDKYLFIADFAITPALNPVIYTLRN 291 Norway rat
XP_007655822 248 LPVDKTLAVFDAVITPFLNPIIYTFRN 274 platypus
XP_004609807 272 IXTDKFLATFDTVLTPSPNPFIYTLRN 298 European shrew

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