Conserved Protein Domain Family
7tmA_OR13-like

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cd15232: 7tmA_OR13-like 
olfactory receptor family 13 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors
This group includes human olfactory receptor family 13 (subfamilies 13A1 and 13G1) and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.
Statistics
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PSSM-Id: 320360
Aligned: 25 rows
Threshold Bit Score: 421.281
Created: 17-Jan-2014
Updated: 25-Oct-2021
Structure
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Aligned Rows:
  next features
Feature 1:putative ligand binding pocket [chemical binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                #  ##           ###### #
Q8NGR1        43 VFLFSCFLFLYSGALTGNVLITLAITFNPGlhaPMYFFLLNLATMDIICTSSIMPKALASLvseeSSISYggCMAQLYFL 122 human
XP_007438648  68 LLLFWVFAFIYATGLAANLLLLITISTFKKlhtPMYFLIFNLSLVNIFSISITTPRLLQSLlthrNMVSFygCITQVFFI 147 Burmese python
XP_007444362  16 TLLFWVFMIIYTTALCANILLILTICTFRKlhsPMYFFTVNLSLVNVFSISVTTPKLLQSLwtgrKTISFygCIAQLYLF 95  Burmese python
XP_008114747  16 TLLFWIFTFIYAIALTFNCLLIFTICNCRNlhtPMYFLLINLSLVNIFSISVTTPKLLQALwtqrKIISFygCITQVYLF 95  green anole
XP_007438647  27 MFIFWIFAVIYASALAGNFLLILAIGICSKlhtPMYFLLVNLSVVNVCSISVTVPKMLQNIldqkRTISFlgCIVQVFLF 106 Burmese python
XP_008114746  23 MILFWLFSFIYAVAVISNILTILAINTCSKlhtPMYFLLVNLSVINICSVSVIVPKMLQTIlaerKSITFtgCIAQVYLF 102 green anole
XP_007442387   3 IILFWIFIFIYITALSANFLLILTVCTFRKlhtPMYLFIVNLSLVNVFSISITIPKLLHSLltgrQTISFhgCLTQVYMF 82  Burmese python
XP_007485259  23 LFLLVSFLCIYVTALVGNSLIFFTICASQQlhtPMYFFLGNLSVIDVLCTSTIMPKMLANLyfqrADISFlgCMAQMYLF 102 gray short-tail...
XP_005284317  23 MFLFVLFTSIYMAALTGNLLIVLTITTSTSlhtPMYFLLINLSLINLLSISVSIPKMLHNLlehkKTIAFlgCITQIYLF 102 western painted...
XP_007444442  31 TLLFWSFIFSYVIALVGNFLLISIIWTSKKlhtPMYFLLVNLSLVNVLSISTTTPKLLLTLlsyeSTISFygCITQVFFF 110 Burmese python
Feature 1        #  #                                            # #####                         
Q8NGR1       123 TWAAsSELLLLTVMAYDRYAAICHPlhYSSMMsKVFCSGLATAVWLLCAVNTAIHTGLMlrLDFCGPNVIIHFFCEVPPL 202 human
XP_007438648 148 IWALgSEMLLLSFMAFDRYAAICHPlhYNIIMrKEVCVGIATTVWIAGMIDSAIHAGLMlpLSFCDSNVINHFFCDIPPV 227 Burmese python
XP_007444362  96 IWALgTELLLLSFMAFDRYAAICHPlqYTMIMrKEVCFGIASIVWIAGMMNSAVHACLMlkLSFCNSNVINHFFCDAPPL 175 Burmese python
XP_008114747  96 IWTLgTELLLLSFMAFDRYTAICHPlqYTLIMrKEACVCIAVGAWLVGMVNSAVHAGLMlkLSFRDSNIINHFFCDVPPL 175 green anole
XP_007438647 107 VWALgTEILLLSFMAFDRYAAICQPlhYTVIMkKEVCVGIATGAWVIGMANSAVHAGLLlrLSFCESEDINHFFCDLPPL 186 Burmese python
XP_008114746 103 NLMLgTELMLLALMAFDRYAAICHPfqYMVIMrKEFCLGAVTGLWLIGMANSAIQTGLVaqLSFCDSNVINHFFCELPPM 182 green anole
XP_007442387  83 IWAVgTELLHLSFMAFDRYAAICHPfqYHMIMrKQVCVCAAVGVWVVGLVNTSTHSALLnqLSFCNTNIINHFFCDLPPL 162 Burmese python
XP_007485259 103 TWALvSEVLLLALMAFDRYVAICHPlhYSMVMrSHVCIGMAGSIWAIGICNSAVHTSLAipLSFCSSFIIDHFFCELPPI 182 gray short-tail...
XP_005284317 103 TWTLgSEALVLAAMAFDRYAAVCHPlhYTIIMrKEVCVGLIAGIWIAGVINSAVNTGFVlqLSFCDSNIINHFFCELPPV 182 western painted...
XP_007444442 111 ILFMvTELLLLTSMAFDRYVAICYPlqYTLIMrKEICAAIAVGAWASGLINSSVHSGLVlqLSFCESNIINHFFCDLPPL 190 Burmese python
Feature 1                  #  ### ### ##                                            #  ## ##  #  
Q8NGR1       203 LLLSCsstyvNGVMIVLADAFYGIVNFLMTIASYGFIVSSIlkvktaWGRQKAFSTCSSHLTVVCMYYTAVFYAYISPvs 282 human
XP_007438648 228 LDLACsdtsrNESMTKVANVVYGMGSCGLTLTSYFFIMRTIfrirstEGKKKAFSTCSSHLLVVSFYFSAIIYMYIRPss 307 Burmese python
XP_007444362 176 MHLSCsdtslNESMAFVSDVTFGIVCCGLTLTSYFLIIRAIcrirstEGKKKAFSTCSSHFIVVSIFYSSVIYTYIRPts 255 Burmese python
XP_008114747 176 LKLASsdtsiNESMAFAADVILGIFNCGLTLMSYFFIMRTIfrirstEGKKKAFSTCSSHLIVVSFYFSSVIYTYIRPss 255 green anole
XP_007438647 187 WKLSCsdislNEIMAFAADVTFTMSSCTLTLISYLLILRTIikiqsvKGKKKAFSTCSSHLLVVSFYFSTIIYTYAKPst 266 Burmese python
XP_008114746 183 FNISCsdtslNESMVFVASVTIVIGSCAVTLTSYCFIVRDIikirstESKRKAFSTCSSHLLVVSFYYSTIIYTFLRPas 262 green anole
XP_007442387 163 LHLSCsdsalSVVVLSASDWILGVGCCGFTLTSYFFIIRTIcrirstEGKKKAFSTCSSHFFVVSIFYSSVIYTYIRPss 242 Burmese python
XP_007485259 183 LKLSCsdtslNEALAFCADVIFGVGSCSLILVSYGCIIRTIlkirssEGKKKAFSTCSSHLTVVSFYYSTVIYTYIRPts 262 gray short-tail...
XP_005284317 183 LQLSCsdislNETLTFLADTVFGMGSCVVTLTSYYFILRTIlkirstEGKKKAFSTCSSHLIVVILYYSTAIYTYIHPss 262 western painted...
XP_007444442 191 FKLSCsdtslNETMASVADIIFAVFGCGLTLTSYGFIIRTIfrirstKGKKKAFSTCSSHLIVVTFFFSSVIYTYIRPts 270 Burmese python
Feature 1           ## ###  #  ##              
Q8NGR1       283 gySAGKSKLAGLLYTVLSPTLNPLIYTLRN 312 human
XP_007438648 308 aySLDKDKLVSLIYSMATPVVNQQIYSLRN 337 Burmese python
XP_007444362 256 vySPDQDKKIALLYSVVTPVLNPVIYSLRN 285 Burmese python
XP_008114747 256 vySLDKDKLVSLLYTVVTPVLNPIIYFMRN 285 green anole
XP_007438647 267 pnDEEEYKNIAIIYSVVTPVLNPIIYSLRN 296 Burmese python
XP_008114746 263 aySLEEDKVIAIIYSVLIPVLNPLIYSLRN 292 green anole
XP_007442387 243 ayAPEQDKIVALLYSVVTPLANPVIYSLRN 272 Burmese python
XP_007485259 263 nlSLGRDKVITALYSVIIPMLNPMIYSFRN 292 gray short-tailed opossum
XP_005284317 263 aySPDRDKVITVLYSVITPALNPIIYSLRN 292 western painted turtle
XP_007444442 271 vfSLNRDKYISLLYSVVTPVINPVIYSLRN 300 Burmese python

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