Conserved Protein Domain Family
7tmB2_GPR113

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cd15253: 7tmB2_GPR113 
orphan adhesion receptor GPR113, member of the class B2 family of seven-transmembrane G protein-coupled receptors
GPR113 is an orphan receptor that belongs to group VI adhesion-GPCRs along with GPR110, GPR111, GPR115, and GPR116. The adhesion receptors are characterized by the presence of large N-terminal extracellular domains containing multiple adhesion motifs, which play critical roles in ligand recognition as well as cell-cell adhesion and cell-matrix interactions, linked by a stalk region to a class B seven-transmembrane domain. GPR113 contains a hormone binding domain and one EGF (epidermal grown factor) domain, and is primarily expressed in a subset of taste receptor cells. In addition, almost all adhesion receptors, except GPR123, contain an evolutionarily conserved GPCR-autoproteolysis inducing (GAIN) domain that undergoes autoproteolytic processing at the GPCR proteolysis site (GPS) motif located immediately N-terminal to the first transmembrane region, to generate N- and C-terminal fragments (NTF and CTF), which may serve important biological functions. However, several adhesion GPCRs, including GPR 111, GPR115, and CELSR1, are predicted to be non-cleavable at the GAIN domain because of the lack of a consensus catalytic triad sequence (His-Leu-Ser/Thr) within their GPS.
Statistics
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PSSM-Id: 320381
Aligned: 6 rows
Threshold Bit Score: 408.38
Created: 11-Nov-2013
Updated: 25-Oct-2021
Structure
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Aligned Rows:
  next features
Feature 1:putative polypeptide ligand binding pocket [polypeptide binding site]
Evidence:
  • Comment:based on mutagenesis of human glucagon receptor (GCGR), and modeling studies of GCGR and other related class B GPCRs
  • Comment:Residues in the globular N-terminal extracellular domain and the extracellular loops of the 7TM domain may also be involved in ligand binding.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                #   #                                               #  ##  #        #    
Q8IZF5        767 EPALALLTQVGLGASILALLVCLGVYWLVWRVVVRNKISYFRHAALLNMVFCLLAADTCFLGAPFLSpgprspLCLAAAF 846  human
XP_008122244  608 SAALTVLSTVGLCASVVALMATLLIYYLVWTSVVKNKVSYFRYTTLANLAFSLLLASLCFLTASRLTaghespLCVAAAF 687  green anole
XP_001509384  631 RSSLTLLSQVLLGASVLALLLCLGMYRAVWHVVIRNKVSYFRHAALVNVVFCLLAADICFLGASLLPsspqspLCLTVAF 710  platypus
XP_008171195  233 SFWLDFLSQFGVCASILALILCLGIYYLVWRLVVRNKISYFRYMTLVNIALSLLMANAWFLGSTWMTpsheneLCVAATF 312  western paint...
XP_006258721  690 GFWLSFLSQLGVCASIAALLLCLSIYRLAWPTVVRSKVSYFRYMTLVQICLSLLLGNLWFVGGARLAaegwgeLCMAAAF 769  American alli...
XP_004918428  293 LLFIDEITYAGLGASILSLCVCIITECLVWKSVVRNNISYFRHISLVNIAVSLLFADTLFFAATFPSvtnykfICLSITF 372  western clawe...
Feature 1           #                                                                           ##
Q8IZF5        847 LCHFLYLATFFWMLAQALVLAHQLLFVFHqlakhRVLPLMVLLGYLCPLGLAGVTLGLYLPQGQYlregeCWLdgKGGAL 926  human
XP_008122244  688 FCHFFYLATFFWMLVQALMLFHQLVFVFHrlsmsAVAPAMLALGYLCPLAIAAATVAAAFPARQYlqeglCWLsaRSKAL 767  green anole
XP_001509384  711 LCHFLYLATFFWMLAQALVLAHQLLFVFHqlskrRVLPLMITLGYLCPLGLAAATLGKYFPQGQYlkkgtCWLdaEGGAQ 790  platypus
XP_008171195  313 FTHFFYLAMFFWMLVQALMLFHHLVFVFHqlaraSVTPLLVTIGYLCPLLIAAADITIYYPKRGYvqataCWLngHNGAI 392  western paint...
XP_006258721  770 FMHFFYLATFFWMLVQAXMIFHQLVFVFHqlaraSVTPFMVTVGYLCPLAIAVATVAVYQPRQQYlhptaCWLsgYSGAV 849  American alli...
XP_004918428  373 LNHFFYLALFFWTFCQSVMLLHQLLFVFHhlrkrIFLSLSFFVGYFIPALIAAGTFLYFYPKNTYlhqsvCWLnpESGAI 452  western clawe...
Feature 1          # #                                                       #  #               # 
Q8IZF5        927 YTFVGPVLAIIGVNGLVLAMAMLKLLRPSLSEGPpaekrqALLGVIKALLILTPIFGLTWGLGLATLLEe---vSTVPHY 1003 human
XP_008122244  768 YAFSIPVLAIVAVNLAVLVVVLMKLMRPSVSEAPpgeerwALVGLFKALLVLTPVFGLTWGLGVITMTGq---aSPATHY 844  green anole
XP_001509384  791 YLFVVPVLTIVGVNAVVLALALLKLTRPTPSEGPrpeerhALMSIFKALLILTPVFGLTWGLGLANLMEe---iSEVPHY 867  platypus
XP_008171195  393 YAFSVPVLVIVLVNVLILFVVVMKLMRPSLSEGPkgeerkTLISILKALLILTPIFGLTWGLGVITMTSk---sSDLSHY 469  western paint...
XP_006258721  850 YAFSGPVLLVVLANLLILFVVVMKLMRPSVSEGPpaddrkALLGILKALLVLTPVFGLTWGLGAATMAGd---sSRGSHY 926  American alli...
XP_004918428  453 YTFAIPAGSIIMFNFMTLMVVISKLSRPSVSEANrpedreTAKSIMKAVLVLTPVFGLTWSFGFALLKDldsltRQIFTY 532  western clawe...
Feature 1           #                               
Q8IZF5       1004 IFTILNTLQGVFILLFGCLMDrKIQEALRKRFCR 1037 human
XP_008122244  845 AFTLLNAFQGVFILIFGCLMD-RKIAHLHGLSCD 877  green anole
XP_001509384  868 LFVVFNASQGIFILLFGCLMDkKMREALLKRLGC 901  platypus
XP_008171195  470 VFAALNSFQGVSILVFGCLMDkKVRDALLERIQK 503  western painted turtle
XP_006258721  927 TFSILNSLQGVFILVFGCLLDkKVREALLRRLHK 960  American alligator
XP_004918428  533 GFAGLNAFQGFFILLTCLTEK-KVRDALTNKVSS 565  western clawed frog

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