Conserved Protein Domain Family
7tmA_mAChR_DM1-like
?
cd15301: 7tmA_mAChR_DM1-like 
muscarinic acetylcholine receptor DM1, member of the class A family of seven-transmembrane G protein-coupled receptors
This subgroup includes muscarinic acetylcholine receptor DM1-like from invertebrates. Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. In general, the exact nature of these responses and the subsequent physiological effects mainly depend on the molecular and pharmacological identity of the activated receptor subtype(s). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.
Links
?
Statistics
?
PSSM-Id: 320428
Aligned: 5 rows
Threshold Bit Score: 373.774
Created: 4-Jul-2013
Updated: 17-Oct-2022
Structure
?
Aligned Rows:
Download Cn3D
  next features
Feature 1:putative ligand binding site [chemical binding site]
Evidence:
  • Comment:based on sequence similarity to Human M2 muscarinic acetylcholine bound an antagonist (3-quinuclidinyl-benzilate), contacts at 4A.
Scroll to Sequence Alignment Display
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                                    #
XP_395760  34 VLIVIIALFLSLTTVVGNIMVMISFKIDKQlqtiSNYFLFSLAVADFAIGLISMPLFTVYTVlgyWPLGphiCDTWLALD 113 honey bee
P16395    105 VVMGFVAAILSTVTVAGNVMVMISFKIDKQlqtiSNYFLFSLAIADFAIGAISMPLFAVTTIlgyWPLGpivCDTWLALD 184 fruit fly
Q9U7D5     66 VMIVVIGAMFALVTSLGNLMVMVSFKIDKQlqtiSNYFLFSLAVADIAIGVISIPMFTYYTAiqkWDLGytmCQFWLCID 145 nematode
EEC03023   48 ILIAILAALLSTLTIIGNLMVMISFKLDKQlqtiSNYFLLSLAIADFSIGVISMPLFTMYTLydhWPLGtfiCDTWLAFD 127 black-legged tick
EFV59983   63 LAIVIVGFVLSLVTTGGNVLVIMSFKMDKQlqtiNNYFLLSLAVADLVVGCVSIPLMTVYTAsgsWPLGyevCQLWLNID 142 Trichinella spiralis

Feature 1     #  ##                                              #                            
XP_395760 114 YLASNASVLNLLIISFDRYFSVTRPltYRAKRtTSKAAIMIACAWGISLLLWPPWIYAWPYiegqrtvpinACYIQFiet 193 honey bee
P16395    185 YLASNASVLNLLIISFDRYFSVTRPltYRAKRtTNRAAVMIGAAWGISLLLWPPWIYSWPYiegkrtvpkdECYIQFiet 264 fruit fly
Q9U7D5    146 YLMSNASVLNLLLISFDRYFSVTRPlsYRPRRtTKKALTMIACTYIISLILWPPWIISWPYiegkftaepgTCVVQFlqt 225 nematode
EEC03023  128 YLTSNASVLNLLIISFDRYFSVTRPltYRARRtTKRAAIMIASAWVISLVLWPPWIYSWPYiegrrsvpvdRCYIQFlet 207 black-legged tick
EFV59983  143 YLVSNTSVLNLLLISFDRYLSVTRPltYRPRRtRVKAIVMITSTFIISLLIWPPWIIAWPYiegkf-ipagTCIVQFlit 221 Trichinella spiralis

Feature 1         #  ##  ##                                                                   
XP_395760 194 NHYITFGTAIAAFYVPVTVMIILYWRIWKETKKRQKdlpylqagkqdaskrsnssdealdmedcrrprsesstgvedvna 273 honey bee
P16395    265 NQYITFGTALAAFYFPVTIMCFLYWRIWRETKKRQKdlpnlqagkkdsskrsnssdentvvnhasggllafaqvggndhd 344 fruit fly
Q9U7D5    226 NPYVTVGTAVAAFYLPVTIMCILYTRVYWETQKRQKefgklqatqtwasdvvdrpstqsfrnskmwkkvkkfsrrsmkrd 305 nematode
EEC03023  208 NIYVTFGTALAAFYVPVTVMCILYWRIWRETEKRQKdltqlqagkkdgsrkstssddpaesedfrrgrsdscapdvetty 287 black-legged tick
EFV59983  222 NPYVTLGTACAAFYVPVTIMVILYAQVYNVTKRRSEeikklqgfhkksmcfirgnrataqlqfhshhrnppshhsnhnhh 301 Trichinella spiralis

Feature 1                                                                                     
XP_395760 274 thiavsylekhypqyktkhrpfswmwlkmwciawwhsgredddeeediegaessrathgydeaitplsaetpltgtvsrs 353 honey bee
P16395    345 twrrprsesspdaesvymtnmvidsgyhgmhsrkssikstntikksytcfgsikewciawwhsgredsddfayeqeepsd 424 fruit fly
Q9U7D5    306 vsstsiikssgsmrkknnqdgyvedsvtpctssrnskrkswlrnctgksnsssedsseavamnlddtslssshfalsgsr 385 nematode
EEC03023  288 vptslcvetskylppavpkrrrlkdvllswcridndkedddstshggspgtqtpasvetpvqsasmtfradqlvqln--- 364 black-legged tick
EFV59983  302 rhhchlqlqsslehpttapvqlppsviiqtsgicepqhqqhqqtsqnahycdqsvpksaapssprlgkriryflkqskre 381 Trichinella spiralis

Feature 1                                                                                     
XP_395760     --------------------------------------------------------------------------------     honey bee
P16395    425 lgyatpvtietplqssvsrctsmnvmrdnysmggsvsgvrppsillsdvsptplprpplasisqlqemsavtasttanvn 504 fruit fly
Q9U7D5    386 rrni---------------------------------------------------------------------------- 389 nematode
EEC03023      --------------------------------------------------------------------------------     black-legged tick
EFV59983  382 cqlsknstrryshpenrrllkmsssyvenerrsfnppplhqpvlgkvfsegehcqla----------------------- 438 Trichinella spiralis

Feature 1                                                                                     
XP_395760     --------------------------------------------------------------------------------     honey bee
P16395    505 tsgngngainnnnnashngngavngngagngsgiglgttgnathrdsrtlpvinrinsrsvsqdsvytilirlpsdgass 584 fruit fly
Q9U7D5    390 ------------------------------------------------------------------------------sp 391 nematode
EEC03023      --------------------------------------------------------------------------------     black-legged tick
EFV59983  439 -------------------------ypsfanisssgmsscesedgfsfgksdvleimaelekrsedndvddeqscdevee 493 Trichinella spiralis

Feature 1                                                                                     
XP_395760 354 -aslsgihpttltveraisiadnhdykksgkagelstksissdsvytilirlptrdtsgmgkysegpsikmyhdetvsps 432 honey bee
P16395    585 naangggggpgagaaasaslsmqgdcapsikmihedgptttaaaaplasaaatrrplpsrdsefslplgrrmshaqhdar 664 fruit fly
Q9U7D5    392 pctpmptnfedeeqtdagasmrngsarfrsrpsdtgknnnsdtytvlielndegsrpsvrlsscepyldepistrnrsks 471 nematode
EEC03023  365 ----pagrqvsipmtdrnglrrsdrpstsrsyssdsvytilirlptqpsleggasqasikmileedaeknettttfarts 440 black-legged tick
EFV59983  494 ivgesaevdadigivdetlskhqqldeqhqqhldqeqleqleheqqriilpkqhrsstfsikteqkssltdgvgstgypa 573 Trichinella spiralis

Feature 1                                                                      #  ##          
XP_395760 433 mitrrpshmpdiriplntknipkalgskpaankttnkkkkklqekKADRKAAKTLSAILLAFIITWTPYNILVLIKsita 512 honey bee
P16395    665 llnakvipkqlgkagggaagggvggahalmnarnaakkkkksqekRQESKAAKTLSAILLSFIITWTPYNILVLIKpltt 744 fruit fly
Q9U7D5    472 dcnseiderrhsllnkqspfkngrilknfssqerksekeqrknerKQESKAAKTLSAILCAFIATWTPYNLIVCWEaffp 551 nematode
EEC03023  441 sedsttlrtaeagidtiriplntklvhrqvakqkapkkkrkqqerKQEKKAAKTLSAILLAFIVTWTPYNVLVLIKtvss 520 black-legged tick
EFV59983  574 spsrptlshmipsfltmtiggstganirsklmklnqnirfaaklrRSESKAAKMLSVILLAFIVTWTPYNVIVLIEaffp 653 Trichinella spiralis

Feature 1                  #  ##                     
XP_395760 513 cswyiPQELWDFFYYLCYINSTVNPMCYALCNaaFRRTY 551 honey bee
P16395    745 csdciPTELWDFFYALCYINSTINPMCYALCNatFRRTY 783 fruit fly
Q9U7D5    552 --ntvPNVLWTFSYFLCYINSTINPLCYALCNarFRHTY 588 nematode
EEC03023  521 cddciPTGLWNFVYYLCYINSTVNPLCYALCNanFRRTY 559 black-legged tick
EFV59983  654 --qtvPSYFFKLSYYLCYLNSTINPLCYALCNraFRRTY 690 Trichinella spiralis

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap