Conserved Protein Domain Family
7tmA_NMU-R2

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cd15357: 7tmA_NMU-R2 
neuromedin U receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors
Neuromedin U (NMU) is a highly conserved neuropeptide with a common C-terminal heptapeptide sequence (FLFRPRN-amide) found at the highest levels in the gastrointestinal tract and pituitary gland of mammals. Disruption or replacement of residues in the conserved heptapeptide region can result in the reduced ability of NMU to stimulate smooth-muscle contraction. Two G-protein coupled receptor subtypes, NMU-R1 and NMU-R2, with a distinct expression pattern, have been identified to bind NMU. NMU-R1 is expressed primarily in the peripheral nervous system, while NMU-R2 is mainly found in the central nervous system. Neuromedin S, a 36 amino-acid neuropeptide that shares a conserved C-terminal heptapeptide sequence with NMU, is a highly potent and selective NMU-R2 agonist. Pharmacological studies have shown that both NMU and NMS inhibit food intake and reduce body weight, and that NMU increases energy expenditure.
Statistics
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PSSM-Id: 320479
Aligned: 4 rows
Threshold Bit Score: 535.212
Created: 29-Dec-2013
Updated: 25-Oct-2021
Structure
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Aligned Rows:
  next features
Feature 1:putative peptide ligand binding site [polypeptide binding site]
Evidence:
  • Comment:based on the structure of Rattus norvegicus neurotensin receptor 1 with bound agonist neurotensin peptide, defined at 4A contacts

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                    #                #  
AAF82755      43 LPVSVVYVPIFVVGVIGNVLVCLVILQHQAmktPTNYYLFSLAVSDLLVLLLGMPLEVYEMWrNYPFLFGpvgCYFKTAL 122 human
AEQ93667      43 LPMALVYSVIFVVGVIGNFLVCLVILKHQNmktPTNYYLFSLAVSDLLVLLFGMPLEVYEMWsNYPFLFGpigCYFKTAL 122 chicken
XP_002940961  45 LPMTLVYATIFLIGVIGNTLVCLVILKHHNmrtPTNYYLFSLAVSDLLVLLLGMPLEVYEMWsNYPFLFGawgCYFKTVL 124 western clawed ...
XP_005988392  43 LPMSLVYAVIFIVGVSGNLLTCFMILKHRNmktPTNYYLFSLAISDLLVLIFGLPIEVYEMWsNYPFLFGdvgCYFKTSL 122 coelacanth
Feature 1                                                                   #                 ###
AAF82755     123 FETVCFASILSITTVSVERYVAILHPFRAKLQStRRRALRILGIVWGFSVLFSLPNTSIHGIkfhyfpngslVPGSATCT 202 human
AEQ93667     123 FETVCFASILSVTTVSIERYFAILHPFRAKLEStRKRALRTIVVLWVLSVLFALPNTGTHGImlqyfpngtlVPGSATCT 202 chicken
XP_002940961 125 FETVCFASILSVTTVSVERYVAIIHPFQAKLKStRSRALKILVTLWIFSILFSIPNTSTHGIllqyfpngslIPDSATCT 204 western clawed ...
XP_005988392 123 FETVCFASILNVTTVSVERYVAIVHPLRAKSNStRERALKIIIVLWVLSVLFSIPNTTIHGIkqsyfpngtlIPDFEICA 202 coelacanth
Feature 1        #                                                                               
AAF82755     203 VIKPmwiYNFIIQVTSFLFYLLPMTVISVLYYLMALRLkkdksleadegnaniqrPCRKSVNKMLFVLVLVFAICWAPFH 282 human
AEQ93667     203 VVAPmwiYNWIVQITSFLFYVLPMGVISVLYYLMGLRLkgdrsleaeemsvnvqrPSRKSVTKMLFVLVMVFAVCWAPFH 282 chicken
XP_002940961 205 VVQPlwiYNCIIQVTSLLFYILPMGVISVLYCLMGIKLrgdhsleadkmsvnvqrPSRKSITKMLFVLVMVFGICWAPFH 284 western clawed ...
XP_005988392 203 VVKPlwiYNLVIQITSLLFYVVPMGVISILYYLMGLKLrddkssetnemniniqrPSRKSVTKMLFVLVLVFAICWAAFH 282 coelacanth
Feature 1         ##  ##            #   #                             
AAF82755     283 IDRLFFSfveewseslaavFNLVHVVSGVFFYLSSAVNPIIYNLLSRRFQAAF 335 human
AEQ93667     283 IDRLFFSfvvewteplaniFNLIHVVSGVFFYLSSAVNPIIYNLLSQRFRMAF 335 chicken
XP_002940961 285 VDRLFFSfvldwteplanaFNLTHVVSGVFFYLSSAVNPLIYNLLSRRFRSAF 337 western clawed frog
XP_005988392 283 VDRLFFSfvvvwteqlanvFNLIHVISGVLLYLSSAVNPIIYNIFSRRFRTAF 335 coelacanth

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