Conserved Protein Domain Family
7tmA_BK-2

?
cd15381: 7tmA_BK-2 
bradykinin receptor B2, member of the class A family of seven-transmembrane G protein-coupled receptors
The bradykinin receptor family is a group of the seven transmembrane G-protein coupled receptors, whose endogenous ligand is the pro-inflammatory nonapeptide bradykinin that mediates various vascular and pain responses. Two major bradykinin receptor subtypes, B1 and B2, have been identified based on their pharmacological properties. The B1 receptor is rapidly induced by tissue injury and inflammation, whereas the B2 receptor is ubiquitously expressed on many tissue types. Both receptors contain three consensus sites for N-linked glycosylation in extracellular domains and couple to G(q) protein to activate phospholipase C, leading to phosphoinositide hydrolysis and intracellular calcium mobilization. They can also interact with G(i) protein to inhibit adenylate cyclase and activate the MAPK (mitogen-activated protein kinase) pathways.
Statistics
?
PSSM-Id: 320503
View PSSM: cd15381
Aligned: 5 rows
Threshold Bit Score: 435.736
Threshold Setting Gi: 632986322
Created: 24-Jul-2013
Updated: 26-Jul-2017
Structure
?
Aligned Rows:
  next features
Feature 1:putative peptide ligand binding pocket [polypeptide binding site]
Evidence:
  • Comment:based on the structures of some angiotensin receptor family (class A) members with bound ligands (agonist peptides or chemical compound agonists/antagonists)
  • Comment:Small-molecule chemical ligands tend to bind deeper within the receptor core, compared to a peptide ligands, which binds towards the extracelllular surface of its receptor.

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
Feature 1              #                                                #  ##   #            #  #
P30411        58 TIQPPFLWVLFVLATLENIFVLSVFCLHKSsctVAEIYLGNLAAADLILACGLPFWAITIsnnFDWLFGetLCRVVNAII 137 human
NP_001026724  53 TFQPGFLWIIFILGTIENAFVLIVLYFHKSrcsVAEIYLANMAFADLMLVCSLPFWAINIsngFQWPFGlfLCKAVNTIN 132 chicken
XP_007910171   3 MAQPIYIVLICAVGMVGNAFVLLVLVLHRVsctVAEIYLGNLAAADLLFVGCLPFWAANIvngYNWPFGefLCKSVSAVI 82  elephant shark
XP_002936112  45 SFQPIYMWIVFVLGFIENMFVLIVFLLHKKrctVAEIYLGNLAAADFLLVCGLPFWAIYIsnkFHWPFGsfLCVFINGLI 124 western clawed ...
XP_006009216  39 TLQPIYLWIISVLGIIGNTVVLSVFCLHKKgctVAEIYLANLAAADLVLCCCLPFWSIYIanhFNWPFGqfLCQTVSAVI 118 coelacanth
Feature 1        #  #                                                  #   #                #    
P30411       138 SMNLYSSICFLMLVSIDRYLALVktMSMGRMRgvRWAKLYSLVIWGCTLLLSSPMLVFRtmkeysdeghnvtACVISYPs 217 human
NP_001026724 133 YMNSYSSIYFLTLVSIDRYLALVktMSLGRMRrtACAKWNSLIIWMCALLICSPTMVFRnlqyfk--eynitACSLDYPt 210 chicken
XP_007910171  83 YMNLFCSVYLLAMVSIDRYLALVhtMTSGRTRspACAKMTCLAIWAFGFLMSTPVILFRtvmakp--eynisACLLRYPs 160 elephant shark
XP_002936112 125 QLNLYGSIYFLMMVSIDRYLALVktMSFGRMRtgRCAKLNCLLIWIFAVVSSMPKTIFRriryfp--efnvtACVIDPPs 202 western clawed ...
XP_006009216 119 YINLYSSLYFLVMISIDRYLALVrtMSIGRMRrsCYAKIICLIIWMFGVLMSTPMIMFRsvsyip--nynitACILKYPn 196 coelacanth
Feature 1                                                                         #  #           
P30411       218 liWEVFTNMLLNVVGFLLPLSVITFCTMQIMQVLRnnemqkfkeiQTERRATVLVLVVLLLFIICWLPFQISTFLDTLhr 297 human
NP_001026724 211 pyWHPANNCLLNAVGFMIPLCIITYCTTQIIKALQsnksqklkliQTERKATLLVLAVLLLFVICWLPFQISTLIDTVcy 290 chicken
XP_007910171 161 egWSLNLEILLLVFAFIVPGSIITFCSCQILQVLRnntmrqfmqvRKETKSSKLVLLVLLMFFLCWLPFHFFTFLSILqk 240 elephant shark
XP_002936112 203 psWNVASGLLLTLVGFLIPVTVISYCSFHIINVLRnnsmqefkeiNKEKKASVLVLVVLLVFIICWLPFHITTFIDTLhm 282 western clawed ...
XP_006009216 197 enWHFAINILLNIVGFLIPLAIITFCSTCIIITLQnnkmkkfkavQTEKKATNLILAVLLMFFICWMPFEVFTFLDTLfv 276 coelacanth
Feature 1                            #   #                     
P30411       298 lgilsscqderIIDVITQIASFMAYSNSCLNPLVYVIVGkRFRKKS 343 human
NP_001026724 291 lagn-lkcledINDIVTQMAIYCAFSNSCLNPILYVIVGkHFQKKA 335 chicken
XP_007910171 241 lglipgcrweaVLENGNQITTFLGFTNNCINPLLYVIVGkHFRKKA 286 elephant shark
XP_002936112 283 mnlfsscamnnFIEIASQISSYLGYSNSFINPLLYVMVGnHFRKKV 328 western clawed frog
XP_006009216 277 gkvisgctwedLLDIGSIISTFVAYSNSFLNPMLYAIAGkHFRTKA 322 coelacanth

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap