Conserved Protein Domain Family
7tmA_leucokinin-like

?
cd15393: 7tmA_leucokinin-like 
leucokinin-like peptide receptor from tick and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors
This subgroup includes a leucokinin-like peptide receptor from the Southern cattle tick, Boophilus microplus, a pest of cattle world-wide. Leucokinins are invertebrate neuropeptides that exhibit myotropic and diuretic activity. This receptor is the first neuropeptide receptor known from the Acari and the second known in the subfamily of leucokinin-like peptide G-protein-coupled receptors. The other known leucokinin-like peptide receptor is a lymnokinin receptor from the mollusc Lymnaeastagnalis.
Statistics
?
PSSM-Id: 320515
View PSSM: cd15393
Aligned: 7 rows
Threshold Bit Score: 436.454
Threshold Setting Gi: 215507473
Created: 16-Dec-2013
Updated: 26-Jul-2017
Structure
?
Aligned Rows:
  next features
Feature 1:putative peptide ligand binding pocket [polypeptide binding site]
Evidence:

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                #  ##           ###### #
AAF72891      56 VLLSIFYGIISLVAVAGNFMVMWIVATSRRmqtvTNFFIANLAVADIIIGLFSIPFQFQAAllqrWVLPefmCAFCPFVQ 135 southern cattle...
ACY92589      20 VILSLLYGVISLMSVLGNALVIFVVLRNKKmrtiTNSFLVNLAISDIIQGLFATPFQFAPAilyrWPFGdfmCPFVPFIK 99  Saccoglossus ko...
EEC16965      55 FLLSFCYGLISLVSIVGNILVLWIVASSRRmqtvTNIFIANLAVADIIIGVFSIPFQFQAAllqrWLLPyfmCAFCPYVQ 134 black-legged tick
AAD11810      62 CLLAFLYGSISLLAVIGNGLVILVIVKNRRmhtvTNIFIPNLAVSDVIIGLFSIPFQFQAAllqrWVLAnfmSSLPPFVQ 141 great pond snail
NP_647968     36 ALLSIFYGGISIVAVIGNTLVIWVVATTRQmrtvTNMYIANLAFADVIIGLFCIPFQFQAAllqsWNLPwfmCSFCPFVQ 115 fruit fly
ELU06581      45 VLLSILYGSISILSVVGNFLVILVIIKNKSmqtvTNFFFANLSVADVMIGIFSIPFQFQAAlsqrWDLPhilCPVAPFVK 124 Capitella sp. I...
NP_001021258  47 IIWCMLYAIIAFMAVVGNLLVLYITLFRLRvrsiTTYFILNLGFADLFTGIFAIPFKFQAAlfqeWFLPrslCRIVPYVE 126 nematode
Feature 1        #  #                                           # #####                          
AAF72891     136 VLSVNVSIFTLTAIALDRYRAVMSPlk-aRTTKLRAKFIICGIWTLAVAAALPCALAlrvetqves-----halnltkpf 209 southern cattle...
ACY92589     100 TLSILVSIGTLTVISVDRYFAVCHPlr-rRLTPCSTAVTVGIIWINGICTSTPKLLNlktiehil-------pdggvrmf 171 Saccoglossus ko...
EEC16965     135 VVSVNVSVFTLTAIAIERYRAITSPlkarFCSKTTAKILILIIWISSLVVACPNAVAlrvvllmdk-----atglrekpf 209 black-legged tick
AAD11810     142 VVTVNLTIFTLRVIAVDRYIAVIHPfk-aGCSKKRAAIIISIIWAVGIGAALPVPLFywvedlte--------nnivipr 212 great pond snail
NP_647968    116 ALSVNVSVFTLTAIAIDRHRAIINPlr-aRPTKFVSKFIIGGIWMLALLFAVPFAIAfrveelterfrennetynvtrpf 194 fruit fly
ELU06581     125 ELTVNVSVITLTVISIDRYFAVLHPlk-aRVSRKVAKIVMSVVWAFSLASAIPVAIVyrvkftddk------htngkkpf 197 Capitella sp. I...
NP_001021258 127 TVALTVSVFTLVTSAVHEFRTMFFSkc-sQMSPRSAKRCVLLIWIMAVLVSLPHGLFhntyefpdd------nntsivqq 199 nematode
Feature 1                     #  ### ### ##                                                      
AAF72891     210 CHEVGIsr---kaWRIYNHVLVCLQYFFPLLTICFVYARMGLKLkeskspgnaqgardagilKNKKKVIKMLFVIVALFA 286 southern cattle...
ACY92589     172 CVPQWSsd---qcRNIYHLYIFVTSYAVPLVVITVAYSLIAKKMyvtktpgesndardqniaKNKKKVITMGIGLVIVFA 248 Saccoglossus ko...
EEC16965     210 CLNVGMqp---rtWKAYNHALVCVQYLLPLTIVCYTYGRIWKKLrqskipgntetvrdahivRNKNKVIKMMAIVVIIFA 286 black-legged tick
AAD11810     213 CDWHAPdnw-ldfHLYYNTLLVCFQYLLPLVIITYCYCRIAWHIwgsrrpgah-vttedvrgRNKRKVVKMMIIVVCLFV 290 great pond snail
NP_647968    195 CMNKNLsd---dqLQSFRYTLVFVQYLVPFCVISFVYIQMAVRLwgtrapgnaqdsrditllKNKKKVIKMLIIVVIIFG 271 fruit fly
ELU06581     198 CSPTFGtfndidlGRVFHLYVAVVQYFLPLVIICYSYFRIMHRIwltkapgsamdtrdqimnRNKRKVIKMLLIVVALFA 277 Capitella sp. I...
NP_001021258 200 CLPVYPda---gwWKTYNVYLVIIQYFVPMIILDTAYTMIAVKIwslsqsr----veldetkMATQKLMRTLIIVVACFS 272 nematode
Feature 1          #  ## ##  #           ## ###  #  ##                     
AAF72891     287 FCWLPYQLYNILRevfpkidkykyINIIWFCTHWLAMSNSCYNPFIYAIYNerFKREF 344 southern cattle tick
ACY92589     249 FCWLPLQLYDFLKfvtpdilsykhINIIWFCCNWLAMSNAACNPFIYGLLNdnFKREY 306 Saccoglossus kowalevskii
EEC16965     287 LCWLPYQTYNLLAeiyptintyryINVIWFCSHWLAMSNSCYNPFIYAIYSekFSAEF 344 black-legged tick
AAD11810     291 LCWLPLQMYNLLHninplinhyhyINIIWFSSNWLAMSNSCYNPFIYGLLNekFKREF 348 great pond snail
NP_647968    272 LCWLPLQLYNILYvtipeindyhfISIVWFCCDWLAMSNSCYNPFIYGIYNekFKREF 329 fruit fly
ELU06581     278 FCWLPLQTYNLLSiilekinkyryINIIWFCSNWLAMSNSCYNPFIYGLLNekFKHSF 335 Capitella sp. I Grassle & Grassle, 1976
NP_001021258 273 LCWFPLETYLLLNelkpeingwkyINLVFFFSHWLAMSNSCLNPIIYGLYNtkYNEEY 330 nematode

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap