Conserved Protein Domain Family
7tmA_OR8B-like

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cd15405: 7tmA_OR8B-like 
olfactory receptor subfamily 8B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors
This group includes human olfactory receptor subfamily 8B and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.
Statistics
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PSSM-Id: 320527
Aligned: 12 rows
Threshold Bit Score: 407.958
Created: 17-Jan-2014
Updated: 25-Oct-2021
Structure
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Aligned Rows:
  next features
Feature 1:putative ligand binding pocket [chemical binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                #  ##           ###### #
Q15620        25 IPLFFLFLGFYVVTVVGNLGLITLIRLNSHLhtPMYFFLYNLSFIDFCYSSVITPKMLMSFvlkkNSISYagCMTQLFFF 104 human
P34985        28 LPLFVLFLMNYTATVMGNLTLMNLICLNSNLhtPMYFFLFNLSFIDFCYSMVFTPKMLMSFilekNTISFggCMAQLFFF 107 house mouse
NP_001000445  25 IPLFLLFLVIYMISTMGNLALIILIFLNSHLhtPMYFFLLNLSCIDLCYCSVGTPKMLMNFvlkeNAISYegCMTQFYFF 104 Norway rat
NP_001000456  25 FPFFFLFLGIYVITVAGNLGLLTLIGMNSPLhtPMYYFLFNLSFIDLCYSTVITPKLLVNFvsekNTISYegCMTQLYFY 104 Norway rat
NP_001000802  25 MPLFFLFLGIYVVTIVANLGLITLISLNSHLhtPMYYFLFNLSFVDICYSSVFTPKMLINFvvekNTISYtgCLTQLYFF 104 Norway rat
NP_001000805  25 ILLFFVFLAMYLVTVLGNLFLIILTVLNSHLhtPMYFFLFNLAFVDLCYSSVFTPQMLMNLitrkNTISYmeCMTQLYFF 104 Norway rat
Q8NGG8        25 QPLFFLFLVVYIVTMVGNLGLIILFGLNSHLhtPMYYFLFNLSFIDLCYSSVFTPKMLMNFvskkNIISYvgCMTQLFFF 104 human
NP_001000965  25 LPLFFLFLVNYITTVVGNLSLMSLICWNSNLqtPMYFFLFNLSFIDLCYSFVFTPKTLMSFvlekNVISFtgCMTQLFFI 104 Norway rat
NP_001001084  28 WPLFVLFLVNYTATVMGNLTLMTLICLNSHLhtPMYFFILNLSFIDFCYSFVFTPKMLMGFvsehNTISFtgCMTQLFFF 107 Norway rat
NP_001000789  29 LPLFFLFLGIYVVSMVGNLGLIVLIVLNPHLhtPMYYFLFNLSFTDLCYSSVITPKMLVGFvk-qNIISHaeCMTQLFFF 107 Norway rat
Q96RC9        25 LPLFLLFLGIYVFTVVGNLGLITLIGINPSLhtPMYFFLFNLSFIDLCYSCVFTPKMLNDFvs-eSIISYvgCMTQLFFF 103 human
ELK09803      26 IPLFFLFLDFYMVIVVGNLGLITLTEQNSHLhtLKYFFFYNLSFIDFHCSTVFTPKVLMSFvskkNIISYa-GCVIQLFF 104 black flying fox
Feature 1        #  #                                            # #####                         
Q15620       105 LFFVVSESFILSAMAYDRYVAICNPllYMVTMsPQVCFLLLLGVYGMGFAGAMAHTAcmmgVTFCANnLVNHY-MCDILP 183 human
P34985       108 LFFVNSESYVLTAMAYDRYVAICKPltYKVIMsPKICCLLIFSSYLMGFASAMAHTGcmirLSFCDSnIINHY-MCDIFP 186 house mouse
NP_001000445 105 CFFIISECYVLTAMAYDRYVAICNPllYNIVMsPKVCSYLMIASYLVGFSDGMIHTGcvlrLTFCDGnTINHY-FCDLLP 183 Norway rat
NP_001000456 105 CFFVSAECYVLTVMAYDRYVAICKPllYTVTMsPQVCSLLTLTVYVGAFIGAWAHTGcmlrLTFCKDnTVNHY-MCDILP 183 Norway rat
NP_001000802 105 CFFVITECYILTAMAYDRYVAICKPllYNVILsPRICALFMFGAYVMGFWGSLAHTLcmarLTFCDAnLVNHY-LCDILP 183 Norway rat
NP_001000805 105 CFFVISECYVLTSMAYDRYVAICNPllYNLVMsSKLCLKLMLGSYFIAFSESVAHTIcimrLTFCKAnTINHY-FCDIPP 183 Norway rat
Q8NGG8       105 LFFVISECYMLTSMAYDRYVAICNPllYKVTMsHQVCSMLTFAAYIMGLAGATAHTGcmlrLTFCSAnIINHY-LCDILP 183 human
NP_001000965 105 CLFVNSECYLLTAMAYDRYVAICQPllYMVIMsPVTCSLMMFGSYVMGFVAAIVHTGfmirLSFCDSnIINHY-MCDIFP 183 Norway rat
NP_001001084 108 CLFVNSECYVLTAMAYDRYVAICRPllYTVVMsPRACCLLMLAAHLMGVSSAIVHTGciihLRFCGSkVINHY-MCDTFP 186 Norway rat
NP_001000789 108 AFFVIDECCILTAMAYDRYAAICKPllYKVIMsHQVCFMLMVGGYTVGFVGAIAHTVsmlrLTFCDGnIINHY-MCDIPP 186 Norway rat
Q96RC9       104 CFFVNSECYVLVSMAYDRYVAICNPllYMVTMsPRVCFLLMFGSYVVGFAGAMAHTGsmlrLTFCDSnVIDHY-LCDVLP 182 human
ELK09803     105 LFFVVSESFTLSAMAYDHYGTICDPlvYTATVsPQVCLFLFLVVYGMGFPGAMAHMVcmirLTFCVNnLIDHSvCDILLS 184 black flying fox
Feature 1                   #  ### ### ##                                            #  ## ##  # 
Q15620       184 LLECACTSTyvNELVVFVVVGIDIGVPTVTIFISYALILSSIfhidstEGRSKAFSTCSSHIIAVSLFFGSGAFMYLKPf 263 human
P34985       187 LLPLSCSSTyvNELMSSVVVGSAIILCCLIILISYAMILFNIihmssgKGWSKALGTCGSHIITVSLFYGSGLLAYVKPs 266 house mouse
NP_001000445 184 LLQLSCTSTyvNEIEVLIISGINIIVPTLIVFTSYGFILSSIlkinstAGRSKAFSTCSSHIIAVSLFFGSGAYMYLKPs 263 Norway rat
NP_001000456 184 LLELSCSSTyiNELVVFIVVGFDVGVPSITIIVSYTFILSSIlhihstEGRSKAFSTCSSHIIVVSVFFGSGAFMYLHPs 263 Norway rat
NP_001000802 184 VLQLSCTSTynNEVVVFVLVGMNIVVSSSTTFVSYGFIIANIlrisstQGRAKAFNTCSSHIMTISLFCGSAIFMYMQPs 263 Norway rat
NP_001000805 184 LLQLSCTTTyiNKLVIFVASSINIIVPISTIFISYGFILSNIfhisssEGRSKAFSTCSSHIIAAFLFFGSGAFMYFKPs 263 Norway rat
Q8NGG8       184 LLQLSCTSTyvNEVVVLIVVGINIMVPSCTILISYVFIVTSIlhikstQGRSKAFSTCSSHVIALSLFFGSAAFMYIKYs 263 human
NP_001000965 184 LLQLSCSSTyaNELVCSVFVSTVVLASSFLILTSYALILFNIiqlssgKGLCKAMSTCSSHIMTVVLFYGFGMLTHIKTs 263 Norway rat
NP_001001084 187 LLELSCGSNhaSELVSSVSVAVVVVMSSLIIVSSYSLILINVihlsssKGWSKAVSTCSSHIITVALFYGFGLLAHIKPs 266 Norway rat
NP_001000789 187 LLKLSCTSTsiNELVVFIVVGVSIIVPSVTVSVSYTLILSNIlrihstKGRSKALSTCSSHMIAVSLFFGSSSFIYFKSs 266 Norway rat
Q96RC9       183 LLQLSCTSThvSELVFFIVVGVITMLSSISIVISYALILSNIlcipsaEGRSKAFSTWGSHIIAVALFFGSGTFTYLTTs 262 human
ELK09803     185 LLMRSCTITh-VNEMVAFVVSIDTGVPTVTIFISYALISSNSlsihstEGSFKDFSTYGSHIIAVSLLFGSRAFMYLKPs 263 black flying fox
Feature 1            ## ###  #  ##                     
Q15620       264 sllAMNQGKVSSLFYTTVVPMLNPLIYSLRNkDVKVAL 301 human
P34985       267 sakTVGQGKFFSVFYTLLVPMLNPLIYSLRNkDVKLAV 304 house mouse
NP_001000445 264 ssgSLDQGKISSVFYNIVVPMMNPLIYSLRNkDVKTAL 301 Norway rat
NP_001000456 264 svlSMDQGKVSTVFYTIVVPMLNPLIYSFRNkEVKVAL 301 Norway rat
NP_001000802 264 dveSMDKGKVASVFYTNVAPMLNPLIYSLRNkDVKLAL 301 Norway rat
NP_001000805 264 sggSMNEGKISSVFYTNVIPMINPLLYSLRNkDIKVAL 301 Norway rat
Q8NGG8       264 s-gSMEQGKVSSVFYTNVVPMLNPLIYSLRNkDVKVAL 300 human
NP_001000965 264 sdeSVNQGKFFCLLCTFLMPLLNPFIYSLRNkDVKLAL 301 Norway rat
NP_001001084 267 sseSVVQRKFFSVVYTFVLPLLNPLIYSLRNkDVKLAV 304 Norway rat
NP_001000789 267 pvgSVDQDKISTVFYTVVVPMMNPFIYSLRNkDVQIAL 304 Norway rat
Q96RC9       263 fpgSMNHGRFASVFYTNVVPMLNPSIYSLRNkDDKLAL 300 human
ELK09803     264 sllPVNQRKVSSLFYITVVPVRNLVIYSLRNkDINIAL 301 black flying fox

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