Conserved Protein Domain Family
7tmA_GPR34-like

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cd15920: 7tmA_GPR34-like 
P2Y-like receptor and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors
GPR34 is phylogenetically related to the P2Y family of purinergic G protein-coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. GPR34 is shown to couple to G(i/o) protein and is highly expressed in microglia. Recently, lysophosphatidylserine has been identified as a ligand for GPR34. This group belongs to the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. G-proteins regulate a variety of cellular functions including metabolic enzymes, ion channels, and transporters, among many others.
Statistics
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PSSM-Id: 320586
View PSSM: cd15920
Aligned: 5 rows
Threshold Bit Score: 408.418
Threshold Setting Gi: 55742095
Created: 3-Nov-2014
Updated: 26-Jul-2017
Structure
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Aligned Rows:
  next features
Feature 1:putative ligand binding pocket [chemical binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                               #  ##            ###### #
NP_001007218  69 PSLPIGYIIICCVGLLCNTITLYIFFLRRHiessMAVYMQHLALADTLLVLCLPLRVYYHN----TAGPfsvCKAVGVLF 144 zebrafish
XP_005994815  52 VFLPVMYSIICITGLFSNTLALWVFFYSQQrktsISVYMRNLAIADLLLVLCLPFRVLYQN----NEGPlllCKIVGAFF 127 coelacanth
XP_004916954  40 LTLPVMYSIVCGLSLLSNLLALLVFWSNSQrctsMIVYMRNLAVADLLLALCLPFRVAYQNh--nGLLIl--CKIVGAFF 115 western clawed ...
EOA95506      12 VTLPVMYSLIFIVGLLSNTLALWVFSCGTQrrtsITVYMRNLALSDLLLSLCLPFRIAFQN----KSEPrifCNVVGAFF 87  mallard
XP_007892655  36 TVLPIIYSLICVVGLASNSLALWVFFRIQRkptsISVYMKNLAIADLLLCLCLPFRIAYHIgeykWMVKcyfCKIIGASF 115 elephant shark
Feature 1        #  #                                            # #####                      #  
NP_001007218 145 YINMYSSILFLTLISLDRYLKIIKPvWVFSIQkkXWSXKASYGVWVLLILGMIPFLIgsgqkhacdNICFHFhskgiVAG 224 zebrafish
XP_005994815 128 YLNMYASILFLSFISLDRYLKITKPlQQFKIHsvPWSSAATGAVWLSTFFCMLPFCFekrnetpcdKKCFHFrkkglTGG 207 coelacanth
XP_004916954 116 YLNMYASIMFLSLISLDRYLKIIRPlQKYKIHsvSWSTRATWIIWLINLVCIIPFLFenrt-gpcsQKCFHFqrkglTGA 194 western clawed ...
EOA95506      88 YLNMYVSITFLSLISLDRYLKIIRPlQKFKIHtvACSTAASGLVWLVHLAFMMPFFFetreegpceYKCFHFrnkstTAA 167 mallard
XP_007892655 116 YSSMYISILFLGLISLDRYLKITKPlKQFRIHtvPWSSAVSKFVWVGVLACMLPFVIssfn-sstqEKCFHYkeqtmTSG 194 elephant shark
Feature 1        ### ### ##                                                   #  ## ##  #        
NP_001007218 225 GVNISTVVIFIIFYIVFISFYIKIIHKLkgmsl---gngdlKAKKRVMIKTFLVPAIFTVCFLPYHAVRIPYVLAQldvi 301 zebrafish
XP_005994815 208 IINLTAVTMFYILSLLFLFFYSKIAVKLykvfrnnahqqikKKNPKAILKTFVVLAVFILCFVPYHIVRVPYVFSQmgii 287 coelacanth
XP_004916954 195 VINLTAVISFFILLLLFVYFYAKISSKLhkaslgrtqpqtkRNSNRAMKKTFIVLIIFIVCFVPYHIVRVPYILAQidii 274 western clawed ...
EOA95506     168 AFNMTAVVIFFILLLLFLYFYGKIFAKLhrvssvnaqqlnkKTSMRAITKTFVVLIIFIVCFTPYHIVRVPYILAQvevi 247 mallard
XP_007892655 195 LMNLVAIAIIYILSLLFLVSYAKISIKLynisqgkakqqikKVSTRAIMKTFIVLAIYMVCFMPYHIVRVPYVLSQikvi 274 elephant shark
Feature 1                ## ###  #  ##                     
NP_001007218 302 adlpsqqlLHVLNESTLLLSTLNSCLDPIIYYFLSssYRKTI 343 zebrafish
XP_005994815 288 kgtksqqyLHIMNELVLCLSAFNSCLDPMIYFFLSntFRRTV 329 coelacanth
XP_004916954 275 dtvpwkqtLHIANELVLCLSTLNSCLDPVIYFFLSdsFKQAV 316 western clawed frog
EOA95506     248 sslpwkqgLHLANELVLCISALNSCLDPVVFFFLSssFRRAV 289 mallard
XP_007892655 275 sscewkqtLHIANELVLCLSALNSCLDPIIYFFLSnsFRRAV 316 elephant shark

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