Conserved Protein Domain Family
7tmA_OR4Q2-like

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cd15938: 7tmA_OR4Q2-like 
olfactory receptor 4Q2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors
This group includes human olfactory receptor 4Q2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.
Statistics
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PSSM-Id: 320604
Aligned: 3 rows
Threshold Bit Score: 442.774
Created: 12-Dec-2014
Updated: 25-Oct-2021
Structure
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Aligned Rows:
  next features
Feature 1:putative ligand binding pocket [chemical binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                 #  ##           ###### 
P0C623        25 AGLFVLFLFFYMSIWVGNVLIMVTVASDKYLnssPMYFLLGNLSFLDLCYSTVTTPKLLADFFnhEKLISYdQCIVQLFF 104 human
XP_006128352  27 AALFSVFLLVYIATLVGNSLIMATVSSDPHLr-tPMYFLLGNLSFLDLCYSTVTAPKMLLDFLseRRSISYpACMAQLFF 105 Chinese soft-sh...
EMC81374      32 VLFFALFFLAYTMVLLGNLLIIVTVRTNPKLs-sPMYFLLCNLSFIDICCISVTCPRMLVDLLsqRKAIAFeACIAQLFF 110 rock pigeon
Feature 1        ##  #                                            # #####                        
P0C623       105 LHFVGAAEMFLLTVMAYDRYVAICRPLhYTTVMsRGLCCVLVAASWMGGFVHSTVQTILTvhLPFCGPNQVENFFCDVPP 184 human
XP_006128352 106 LHFVGAAEMFLLTVMAYDRYVAICKPLhYPSIMnRTLCSWLVAASWAGGFIHSLVQTVLTmrLPFCGPNQVDNFFCDVPP 185 Chinese soft-sh...
EMC81374     111 LHFAGASEMFLLTVMAYDRYTAICKPLhYTTIMsRRVCWVLVSACWAGGFLHSIVQTLLTiqLPFCGPNTINNFFCDVPP 190 rock pigeon
Feature 1                   #  ### ### ##                                           #  ## ##  #  
P0C623       185 VIKLACadtfvIELLMVSNSGLISTISFVVLISSYTTILVKIrs--kEGRRKALSTCASHLMVVTLFFGPCIFIYARPfs 262 human
XP_006128352 186 VIKLACtdtyvVELLMVSNSGLISTSCFVVLVASYATILVRIrs--pEGRRKALSTCASHLTVVTLFFGPCIFIYARPfs 263 Chinese soft-sh...
EMC81374     191 VIRLACtdicvTEWLMASNSGLISLVCFLVLVTSYTFILVTIrvrftEEHWKALSTCASHVMVVTIFFVPCIFIYLRPfs 270 rock pigeon
Feature 1         ## ###  #  ##              
P0C623       263 TFSVDKMVSVLYNVITPMLNPLIYTLRN 290 human
XP_006128352 264 IFPVDKLVSVLYNIITPTLNPMIYTLRN 291 Chinese soft-shelled turtle
EMC81374     271 TFPSDKHICVIYTVLSPMLNPLIYTLRN 298 rock pigeon

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