3LHO


Conserved Protein Domain Family
VOC_like

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cd16350: VOC_like 
Click on image for an interactive view with Cn3D
uncharacterized subfamily of the vicinal oxygen chelate (VOC) family
The vicinal oxygen chelate (VOC) superfamily is composed of structurally related proteins with paired beta.alpha.beta.beta.beta motifs that provide a metal coordination environment with two or three open or readily accessible coordination sites to promote direct electrophilic participation of the metal ion in catalysis. VOC domain is found in a variety of structurally related metalloproteins, including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases. A bound metal ion is required for protein activities for the members of this superfamily. A variety of metal ions have been found in the catalytic centers of these proteins including Fe(II), Mn(II), Zn(II), Ni(II) and Mg(II). The protein superfamily contains members with or without domain swapping. The proteins of this family share three conserved metal binding amino acids with the type I extradiol dioxygenases, which shows no domain swapping.
Statistics
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PSSM-Id: 319960
Aligned: 90 rows
Threshold Bit Score: 231.659
Created: 7-Dec-2015
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
Conserved Features/SitesClick to see Conserved Features Help
 
metal binding
Conserved site includes 4 residues -Click on image for an interactive view with Cn3D
Feature 1: metal binding site [ion binding site], 4 residue positions
Conserved feature residue pattern:H H T EClick to see conserved feature residue pattern help
Evidence:
  • Structure:3LHO: Shewanella frigidimarina putative hydrolase binds Ni(2+)
    View structure with Cn3D

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                          #                             
3LHO_A         6 VNALFAALWQDYikxTPSAAKIHQLLGH---------------GAPIINDHIALRTFNIAk--------VNLSVLAKHFT 62  Shewanella frig...
WP_040472538   4 LQKIFDGLMERYkadVPDVSKITKAMVDqyi---------iqnQFDIENDHVAFRTIGIPk--------LGIKAFEKIFL 66  Flavobacteriace...
CCH03133      59 LQTVLSGLMRRYterVPDVQRIIDAMIDadm---------idsAADIENDHIAFRTMGVPn--------LGIASFEKIFL 121 Fibrella aestua...
WP_028458975  11 FEQVLDGLMRRYrerVPDVTAIAHAMVAegi---------iatPDQIENDHIAFRTMGVPh--------LGIRSLEKIFL 73  Chloroflexus sp...
WP_013179105  10 LQGVLDGLMRRYkarVPDVEAILQAMTAegi---------irtPEEIENDHIAFRTMGVPh--------LGIASLEKVFL 72  Truepera radiov...
WP_028296893   9 WEKVLDGLMGRYrqrVPDVGAIIAAMKTegi---------idsEKEIENDHIAFRSLGVPh--------LGIASMEKIFL 71  Olivibacter sit...
WP_026914935   9 LNELLNSLIIPYkerVPDVYRIINGMLEkgm---------iskEEDIINDHIAFRTLGLPy--------LGITSLEKIFL 71  Gramella portiv...
CEG00031      22 AKRSIAELVRGYfahNASARTACEHLMRvsgetmenltdaeyvARETPLDHLAFRSLGTKdmgidgvceRFEACGYVLCE 101 Ostreococcus tauri
EKD72011       6 RQHIIKNLWERYhvtTPHIKIIEEALARk-------------nISPLALDHFAIIDLPGLh--------SGIPQLKDIFT 64  uncultured bact...
WP_010597443   6 ADRVFSALWQNYcldYPLASLIYETIQTq-------------yNTVIPWDHVAFIDLPGPh--------TGRIPLIELWQ 64  Diplorickettsia...
Feature 1                                                                                        
3LHO_A        63 SIGYVDSGDYKFEQKKLIAKHFEHPDp-------KQPKVFISELLVEEFSPEVQKSIHGLIDQVDia------------- 122 Shewanella frig...
WP_040472538  67 NYGYKARDRYNFESKKLNARWYASPTn-------KFPRVFISELRIHEFPKNIQELILKYTNEITndpike--------- 130 Flavobacteriace...
CCH03133     122 ALGYEKRDPYQFVEKKLNAWWYAPPAldgp-hggNLPRIFVSELRVDDLSTTAQAIIHKYTDTVTadpvda--------- 191 Fibrella aestua...
WP_028458975  74 HYGYERRDHYHFPAKKLDAFWYHPPRp-------DLPRIFISELRVNDLSPEAAAIIRSYTDEVTadpvdt--------- 137 Chloroflexus sp...
WP_013179105  73 HYGYRRRDAYDFPAKKLDAYWYSPPEp-------RFPRVFISELRVGELSPEAQRIIHAYTDEVTrdpvda--------- 136 Truepera radiov...
WP_028296893  72 YYGYERRNFYQFDEKKLDAYWYSPPRe-------DLPRIFLSELRVQDLSDKARQVIHRYTDVVQhdpvds--------- 135 Olivibacter sit...
WP_026914935  72 HYGYEKRDYYFFPEKKLNAFWYSHPEn-------KYPRIFISELRVSDLSQNAQKIIQKYTKNINsdpvdn--------- 135 Gramella portiv...
CEG00031     102 ESEDGPAATYRFPEKRVRARWMRPPEtpi--geiALPRIFVSELVLEECDADLRSLVEGVLARVSdgk------------ 167 Ostreococcus tauri
EKD72011      65 LLGYETRGQGYLPDKQNDFVWLAEKNsaqqladqVLPQVVVADFRLHELPSEIKKIIEKYAQQTQhspqeeirdflt-sl 143 uncultured bact...
WP_010597443  65 SIDYEVRGQGYLAEKQNPFVWLAEKNqaqrlakqAWPQVVVADFYRAALAPKVRAIVDYYAAFARpldrqklyalkkral 144 Diplorickettsia...
Feature 1                                                           # #                          
3LHO_A       123 --------atTADNFIYSGRHWd-VDKATYQALLAESEYAAWVAALGYRANHFTVSINDlpe------ferIEDVNQALK 187 Shewanella frig...
WP_040472538 131 ----ldlnnpEQVDDFLHTPLWsvPSWEDYQSLLKVSEYAAWVIYNRYYLNHYTIAVSSlpkg-----fntLESFNDFLN 201 Flavobacteriace...
CCH03133     192 ----ldltdgAAIDAFLHQPLWptPTLADYQTLLAESEYAAWVIYNRYYLNHFTISVHNlpeg-----ynrIDEFVGFLQ 262 Fibrella aestua...
WP_028458975 138 ----ldlndaAQVDDFLHRPLWrlPTWADYQRLAAESEYAAWVIYNRYYLNHFTITVHNlptg-----yntIADFNAFLE 208 Chloroflexus sp...
WP_013179105 137 ----ldlddaGAVDAFLHHPLWrlPSYADYRRLAEESEYAAWVIYNRYYLNHFTISVHNlpeg-----yntVEQFNAFLE 207 Truepera radiov...
WP_028296893 136 ----ldledpMAVDAFLHTAQWpvPTWEDYRALANESEYAAWVIYNRYYLNHYTLAVHHfkqg-----yntIPEFNNFLE 206 Olivibacter sit...
WP_026914935 136 ----idfknvSEVSDFFTSALWelPTLDDYQSLLEESEYAAWVIYNRYYLNHFTISIHDlped-----ynrLEKFNDFLK 206 Gramella portiv...
CEG00031     168 -------vfqSGEYADGRIARWqlPAASTYAKLQKLSEYASWTLLHGYAVNHIAVSLFQlrkkypetpiraLEDVDKAFA 240 Ostreococcus tauri
EKD72011     144 ndanvskkiiDIILNYFCGRDWplPTINEFRAVQEFNELLAWVLIFGRRPNHFTISVHLhpy------fndLEHFNEFIK 217 uncultured bact...
WP_010597443 145 enkecaeewvTFMIDYLKGRDWplPTVEEFTFVKQHNELLAWVLVMGRQVNHFGLAIHLieh------fssLQVFNEWIQ 218 Diplorickettsia...
Feature 1                                                                             #          
3LHO_A       188 QAGFVlns----sggEVKGSPEVLLEQSSTXADKVVVNFTD------------------GDVEIPSCFYEFARRYPXa-- 243 Shewanella frig...
WP_040472538 202 SLGILlsd----aggYIKESPDKLLLQSATVSQLKKAIFAAg-----------------DSHLIAGSYVEFAERKILpey 260 Flavobacteriace...
CCH03133     263 DRGIRlns----sggVVKVSPDGGLRQASTVAQLVEAEFTNg-----------------DTQRIAGSYVEFAERRVLpef 321 Fibrella aestua...
WP_028458975 209 RHGFKlnd----aggKIKVSPDGKLLQSSTVAEMIWAEFAGg-----------------ERHQIAGSYVEFAERRPLdef 267 Chloroflexus sp...
WP_013179105 208 ARGFTlna----aggKAKRSPDGLLIQSSTVAEMIEAEFAGg-----------------ERHKIAGSYVEFAERRPLpef 266 Truepera radiov...
WP_028296893 207 RHGFKlnd----aggKVKQSPDGGLLQSSTVAGKVEASFADg-----------------RKEWIPGSYVEFAERRVLepy 265 Olivibacter sit...
WP_026914935 207 SIEIKlnn----sggEIKESRDGLLKQSSSVAGKVRANFLGs-----------------EVIEIPGSYVEFAQRLVLpef 265 Gramella portiv...
CEG00031     241 ANAALarkpwndrggRIKRSPSGLLLQSSLMSEPHRFNLYKqtqairnrygrddeeeifKEYKLPGSYIEFVQRMPRpeh 320 Ostreococcus tauri
EKD72011     218 TEAKLalnp---dggIIKGGKHTGIAQSSTLGISETVSLAD------------------GNIDIPTGFVEFVWRYSNvsn 276 uncultured bact...
WP_010597443 219 ATLAIplnq---eggLIKGGAQQEIAQSSTAAIKKNVRLAD------------------GPSQLADRFIEFVWRYPKknn 277 Diplorickettsia...
Feature 1                              
3LHO_A       244 ---------NGQLYTGFVAASA 256 Shewanella frigidimarina NCIMB 400
WP_040472538 261 qhiplaeieRKHRKEGFEAANA 282 Flavobacteriaceae bacterium HQM9
CCH03133     322 anvpsdqltRAHRREGFEAGNA 343 Fibrella aestuarina BUZ 2
WP_028458975 268 ahlpphelrREHRREGFEAGNA 289 Chloroflexus sp. Y-396-1
WP_013179105 267 ag--qteltREQRREGFEAGNA 286 Truepera radiovictrix
WP_028296893 266 rhlppdqvkREYRREGFEAQNA 287 Olivibacter sitiensis
WP_026914935 266 sdlplskikKDHRRDGFETGNA 287 Gramella portivictoriae
CEG00031     321 adkafeelnEQDLRDGFESSNA 342 Ostreococcus tauri
EKD72011     277 k-----pnlWSDYFTGFIATHA 293 uncultured bacterium
WP_010597443 278 ed---ksllWSAYFTDFIAKQA 296 Diplorickettsia massiliensis

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