Conserved Protein Domain Family
RING-HC_LONFs_rpt1

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cd16513: RING-HC_LONFs_rpt1 
first RING finger, HC subclass, found in the LON peptidase N-terminal domain and RING finger protein family
The LON peptidase N-terminal domain and RING finger protein family includes LONRF1 (also known as RING finger protein 191 or RNF191), LONRF2 (also known as RING finger protein 192, RNF192, or neuroblastoma apoptosis-related protease), LONRF3 (also known as RING finger protein 127 or RNF127), which are characterized by containing two C3HC4-type RING-HC fingers, four tetratricopeptide (TPR) repeats, and an ATP-dependent protease La (LON) substrate-binding domain at the C-terminus. Their biological functions remain unclear. This model corresponds to the first RING-HC finger.
Statistics
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PSSM-Id: 438176
Aligned: 25 rows
Threshold Bit Score: 53.8509
Created: 31-Jul-2013
Updated: 17-Oct-2022
Structure
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Aligned Rows:
 
Zn binding site
Feature 1: Zn binding site [ion binding site], 8 residue positions
Conserved feature residue pattern:C C C H C C C CClick to see conserved feature residue pattern help
Evidence:
  • Comment:based on the structures of other RING-HC fingers with bound zinc
  • Comment:C3HC4-type RING-HC finger consensus motif: C-X2-C-X(9-39)-C-X(1-3)-H-X(2-3)-C-X2-C-X(4-48)-C-X2-C, where X is any amino acid and the number of X residues varies in different fingers
  • Comment:A RING finger typically binds two zinc atoms, with its Cys and/or His side chains in a unique "cross-brace" arrangement.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1            #  #           # #  #  #          #  #       
Q17RB8       119 GLLRCLGCRGFLSEPVTVPCGHSYCRRCLRREl--rARCRLCRDRLPPA 165 human
Q496Y0       154 DGFKCRKCHGFLSDPVSLSCGHTFCKLCLERGraadRRCALCGVKLSAL 202 human
XP_007883556 128 DVFSCRLCLVLLYEPITVPCGHTFCKSCLEKQa--aAECKLCGRPLHKG 174 elephant shark
XP_014345700 170 DLFSCRLCNRLLVDPSTLQCGHTFCKSCLEREs--iLICRLCKFKVKKL 216 coelacanth
XP_001180621  95 GKFSCCVCRGLLSKPTTLLCGHTFCKSCVEHQs--kRSCVICKFPYSSS 141 purple sea urchin
XP_019647163 102 DVVMCAVCQGLLFEPVTIPCGHTFCKRCIEKDp--sKTCPRCRLRFTEA 148 Belcher's lancelet
XP_021346569  96 CIFTCVLCRGLLSDPVTIPCGHTFCRKCVERDq--sKICKRCGKANHFV 142 Yesso scallop
KDR21972      93 RGFSCRICEGILLQPVTTACGHTFCRRCLERDt--sRNCRQCGQKIAGG 139 Zootermopsis nevadensis
XP_013072506  96 CLFTCGYCLGLLADPVTVPCGHTFCRHCLEKDk--sNYCELCGSVNYRG 142 Biomphalaria glabrata
XP_013421842  97 DMFECGICKGIMNDPVTTPCGHSFCRNCLEREq--sKKCRTCGVVHFYM 143 Lingula anatina

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