Conserved Protein Domain Family
RING-HC_prokRING
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cd16528: RING-HC_prokRING 
RING finger, HC subclass, found in prokaryotic RING finger family proteins
The family corresponds to a group of uncharacterized prokaryotic C3HC4-type RING-HC finger containing proteins. The RING finger is fused to an N-terminal alpha-helical domain, ROT/Trove-like repeats, and a C-terminal TerD domain, suggesting a possible role in an RNA-processing complex.
Links
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Statistics
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PSSM-Id: 438191
Aligned: 3 rows
Threshold Bit Score: 84.5488
Created: 31-Mar-2013
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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Zn binding site
Feature 1: Zn binding site [ion binding site], 8 residue positions
Conserved feature residue pattern:C C C H C C C CClick to see conserved feature residue pattern help
Evidence:
  • Comment:based on the structures of other RING-HC fingers with bound zinc
  • Comment:C3HC4-type RING-HC finger consensus motif: C-X2-C-X(9-39)-C-X(1-3)-H-X(2-3)-C-X2-C-X(4-48)-C-X2-C, where X is any amino acid and the number of X residues varies in different fingers
  • Comment:A RING finger typically binds two zinc atoms, with its Cys and/or His side chains in a unique "cross-brace" arrangement.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1          #  #           # #  #  #        #  #    
Q1CZ12       105 QPCIHCGAQgTVRALSPCAHLVCERCYDGsdysACPICHRRL 146 Myxococcus xanthus DK 1622
WP_035372886 115 QPCLHCSKVgTTHVLNPCRHVVCDACFDGsnhsACPICEAHT 156 Duganella violaceinigra
ACZ86836     135 QPCVLCGKAgAVHAVSPCAHLVCHACWDGsdfaGCPICHRRI 176 Streptosporangium roseum DSM 43021

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