Conserved Protein Domain Family
RING-HC_RNF207
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cd16558: RING-HC_RNF207 
RING finger, HC subclass, found in RING finger protein 207 (RNF207) and similar proteins
RNF207 is a cardiac-specific E3 ubiquitin-protein ligase that plays an important role in the regulation of cardiac repolarization. It regulates action potential duration, likely via effects on human ether-a-go-go-related gene (HERG) trafficking and localization in a heat shock protein-dependent manner. RNF207 contains a C3HC4-type RING-HC finger, Bbox 1 and Bbox C-terminal (BBC) domain, as well as a C-terminal non-homologous region (CNHR).
Links
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Statistics
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PSSM-Id: 438220
Aligned: 8 rows
Threshold Bit Score: 87.029
Created: 20-May-2013
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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Zn binding site
Feature 1: Zn binding site [ion binding site], 8 residue positions
Conserved feature residue pattern:C C C H C C C CClick to see conserved feature residue pattern help
Evidence:
  • Comment:based on the structures of other RING-HC fingers with bound zinc
  • Comment:C3HC4-type RING-HC finger consensus motif: C-X2-C-X(9-39)-C-X(1-3)-H-X(2-3)-C-X2-C-X(4-48)-C-X2-C, where X is any amino acid and the number of X residues varies in different fingers
  • Comment:A RING finger typically binds two zinc atoms, with its Cys and/or His side chains in a unique "cross-brace" arrangement.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1            #  #           # #  #  #           #  # 
Q6ZRF8         22 PLVCPLCHVQYERPCLLDCFHDFCAGCLRGRAtDGRLTCPLCQ 64   human
NP_001188378   22 PLVCHLCQEQYEHPCLLDCYHTFCASCLRGRVaDSRLTCPVCG 64   zebrafish
XP_417536      22 PLVCLLCHGPFQQPCLLDCYHAFCASCLRGRAaSGRLRCPLCG 64   chicken
EEB16535       38 PLICYLCNDYYSNPCLLQCYHTFCLKCLRGREvEGRISCPVCG 80   human body louse
XP_007896067   22 PLVCHLCYQQYEHPCLLDCHHTFCANCLRGRAsDGRLSCPLCG 64   elephant shark
XP_013386035   33 PLLCYLCNEHYEDPCLLKCFHSFCAKCLRGRGaEGKMKCPLCG 75   Lingula anatina
XP_014344191   22 PLVCYLCHEQYEHPCLLDCYHTFCASCLRGRAtDSRLTCPLCG 64   coelacanth
XP_018083450   22 PLACFLCHEQYEHPCLLDCYHNFCASCLRGRAiDNRLTCPLCG 64   African clawed frog

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