Conserved Protein Domain Family
RING-HC_RNF220
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cd16563: RING-HC_RNF220 
RING finger, HC subclass, found in RING finger protein 220 (RNF220) and similar proteins
RNF220 is an E3 ubiquitin-protein ligase that promotes the ubiquitination and proteasomal degradation of Sin3B, a scaffold protein of the Sin3/HDAC (histone deacetylase) corepressor complex. It can also bind E2 and mediate auto-ubiquitination of itself. Moreover, RNF220 specifically interacts with beta-catenin, and enhances canonical Wnt signaling through ubiquitin-specific protease 7 (USP7)-mediated deubiquitination and stabilization of beta-catenin, which is independent of its E3 ligase activity. RNF220 contains a characteristic C3HC4-type RING-HC finger at its C-terminus.
Links
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Statistics
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PSSM-Id: 438225
Aligned: 16 rows
Threshold Bit Score: 108.311
Created: 18-May-2013
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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Zn binding site
Feature 1: Zn binding site [ion binding site], 8 residue positions
Conserved feature residue pattern:C C C H C C C CClick to see conserved feature residue pattern help
Evidence:
  • Comment:based on the structures of other RING-HC fingers with bound zinc
  • Comment:C3HC4-type RING-HC finger consensus motif: C-X2-C-X(9-39)-C-X(1-3)-H-X(2-3)-C-X2-C-X(4-48)-C-X2-C, where X is any amino acid and the number of X residues varies in different fingers
  • Comment:A RING finger typically binds two zinc atoms, with its Cys and/or His side chains in a unique "cross-brace" arrangement.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1          #  #            # #  #  #          #  #           
Q5VTB9       512 YKCLICMDSYSMPLTSIQCWHVHCEECWLRTLgaKKLCPQCNTITAPGDLRR 563 human
ELU14630     370 VRCLICMDSYKQPLVSVQCWHVYCEDCWLRTLgaKKLCPQCNMITSPVDLRR 421 Capitella sp. I Grassle & Grassle, 1976
EDV20082     564 YRCLICMEPYYIPLTSINCWHVHCEECWMRTLgaKKLCPQCNVITSPADLRK 615 Trichoplax adhaerens
ELU45565     278 TVCRICLDPFMEPVVSTGCWHLFCRECWLRSLgsTKYCPICKRITSTSNLRK 329 Rhizoctonia solani AG-1IA
NP_651088    344 YKCLICIDDYKNPAISVSCWHVHCEQCWLQTLgaRKLCPQCNSITTPKDLRR 395 fruit fly
EFX73016     312 NRCLICLGDYRQPVVSTSCWHVHCEECWLQALgnKKLCPQCNLITSPTHLRR 363 common water flea
EAL66055     699 PSCLICMESYKTPLVSINCWHVNCEDCWLASLkeKKLCPQCNIITCPQDLRR 750 Dictyostelium discoideum AX4
XP_006822688 646 HKCLICMESYHTPVVSVQCWHVHCEECWLRTLgaKKLCPQCNMITSPSDLRK 697 Saccoglossus kowalevskii
XP_004365695 372 HKCLICMEPYTNPAVSINCWHVHCQQCWLATLgaKKVCPQCNIITTPAHLRR 423 Capsaspora owczarzaki ATCC 30864
XP_013419765 528 FKCLICMEPYASPLTSIQCWHVHCEECWLRTLgaKKLCPQCNMITSAADLRK 579 Lingula anatina

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