Conserved Protein Domain Family
RING-HC_RNF220

?
cd16563: RING-HC_RNF220 
RING finger, HC subclass, found in RING finger protein 220 (RNF220) and similar proteins
RNF220 is an E3 ubiquitin-protein ligase that promotes the ubiquitination and proteasomal degradation of Sin3B, a scaffold protein of the Sin3/HDAC (histone deacetylase) corepressor complex. It can also bind E2 and mediate auto-ubiquitination of itself. Moreover, RNF220 specifically interacts with beta-catenin, and enhances canonical Wnt signaling through ubiquitin-specific protease 7 (USP7)-mediated deubiquitination and stabilization of beta-catenin, which is independent of its E3 ligase activity. RNF220 contains a characteristic C3HC4-type RING-HC finger at its C-terminus.
Statistics
?
PSSM-Id: 319477
View PSSM: cd16563
Aligned: 21 rows
Threshold Bit Score: 78.9891
Threshold Setting Gi: 391325511
Created: 18-May-2013
Updated: 18-Aug-2016
Structure
?
Aligned Rows:
 
Zn binding siteRING-HC finger
Feature 1:Zn binding site [ion binding site]
Evidence:
  • Comment:Based on the structural evidence that Homo sapiens HHARI (4KBL) binds two Zn2+ ions through its RING-HC finger.

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
Feature 1         #  #            # #  #  #          #  # 
Q5VTB9       513 KCLICMdsYSMPLTSIQCWHVHCEECWLRTLGaKKLCPQCN 553 human
ELU14630     371 RCLICMdsYKQPLVSVQCWHVYCEDCWLRTLGaKKLCPQCN 411 Capitella sp. I Grassle & Grassle, 1976
ELU45565     279 VCRICLdpFMEPVVSTGCWHLFCRECWLRSLGsTKYCPICK 319 Rhizoctonia solani AG-1IA
XP_002406322 169 KCLICMepYTVPVVSVCCWHVHCQDCWLKTLGaKKLCPQCN 209 black-legged tick
NP_651088    345 KCLICIddYKNPAISVSCWHVHCEQCWLQTLGaRKLCPQCN 385 fruit fly
EFX73016     313 RCLICLgdYRQPVVSTSCWHVHCEECWLQALGnKKLCPQCN 353 common water flea
XP_784311    413 KCQICMgaYNTPLVSIQCWHVHCEDCWLKTLAsKKLCPQCQ 453 purple urchin
EAL66055     700 SCLICMesYKTPLVSINCWHVNCEDCWLASLKeKKLCPQCN 740 Dictyostelium discoideum AX4
XP_004365695 373 KCLICMepYTNPAVSINCWHVHCQQCWLATLGaKKVCPQCN 413 Capsaspora owczarzaki ATCC 30864
XP_009859283 599 RCQICMdsYEDPLASIECWHVHCRKCWLRALSvKKLCPQCS 639 vase tunicate

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap