6YXE


Conserved Protein Domain Family
RING-HC_TRIM69_C-IV
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cd16611: RING-HC_TRIM69_C-IV 
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RING finger, HC subclass, found in tripartite motif-containing protein 69 (TRIM69) and similar proteins
TRIM69, also known as RFP-like domain-containing protein trimless or RING finger protein 36 (RNF36), is a testis E3 ubiquitin-protein ligase that plays a specific role in apoptosis and may also play an important role in germ cell homeostasis during spermatogenesis. TRIM69 belongs to the C-IV subclass of the TRIM (tripartite motif) family of proteins that are defined by their N-terminal RBCC (RING, Bbox, and coiled coil) domains, including three consecutive zinc-binding domains, a C3HC4-type RING-HC finger, Bbox1 and Bbox2, and a coiled coil region, as well as a B30.2/SPRY (SplA and ryanodine receptor) domain positioned C-terminal to the RBCC domain.
Links
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Statistics
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PSSM-Id: 438273
Aligned: 7 rows
Threshold Bit Score: 109.463
Created: 2-Feb-2016
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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Zn binding site
Conserved site includes 8 residues -Click on image for an interactive view with Cn3D
Feature 1: Zn binding site [ion binding site], 8 residue positions
Conserved feature residue pattern:C C C H C C C CClick to see conserved feature residue pattern help
Evidence:
  • Comment:based on the structures of other RING-HC fingers with bound zinc
  • Comment:C3HC4-type RING-HC finger consensus motif: C-X2-C-X(9-39)-C-X(1-3)-H-X(2-3)-C-X2-C-X(4-48)-C-X2-C, where X is any amino acid and the number of X residues varies in different fingers
  • Comment:A RING finger typically binds two zinc atoms, with its Cys and/or His side chains in a unique "cross-brace" arrangement.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1              #  #           # #  #  #                 #  #            
6YXE_A        53 ITMELHCPLCNDWFRDPLMLSCGHNFCEACIQDFWRlq----aKETFCPECKMLCQYNNCTFN 111 human
Q86WT6        35 ITMELHCPLCNDWFRDPLMLSCGHNFCEACIQDFWRlq----aKETFCPECKMLCQYNNCTFN 93  human
XP_028926475  52 IMQDLSCPLCRDWFGDPILLACGHNFCSICLSGLWGq-----rEDTYCPECQQLCQDRQGTPN 109 platypus
XP_008104093  10 LCEQLACRICMEYFKKPVILSCGHNFCQSCLDRWWEr------RDAYCPQCREEVQEGDIRPN 66  green anole
XP_014350036  21 LMEELICSVCLDFFQDPVMSDCGHNFCRSCISQYWGeq----eENVTCPDCREVFPGRSLKPN 79  coelacanth
XP_007902296  10 LTEELNCCVCLDFFKDPVLLECGHNFCRSCITGFWEk-----qVPKTCPECRWVSPTNRLRAN 67  elephant shark
NP_001079899   6 LRQELCCSICLDFYRKPVILRCGHNFCQDCITGVFDtqeeeewGFYTCPECRKRFKVRPLPVR 68  African clawed frog

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