Conserved Protein Domain Family
RING-Ubox1_NOSIP

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cd16661: RING-Ubox1_NOSIP 
U-box domain 1, a modified RING finger, found in nitric oxide synthase-interacting protein (NOSIP) and similar proteins
NOSIP, also known as endothelial NO synthase (eNOS)-interacting protein, p33RUL, is an E3 ubiquitin-protein ligase implicated in the control of airway and vascular diameter, mucosal secretion, NO synthesis in ciliated epithelium, and, therefore, of mucociliary and bronchial function. The loss of NOSIP may cause holoprosencephaly and facial anomalies, including cleft lip/palate, cyclopia, and facial midline clefting. NOSIP interacts with neuronal nitric oxide synthase (nNOS) and eNOS by inhibiting the nitric oxide (NO) production. It acts as a novel type of modulator that promotes translocation of eNOS from the plasma membrane to intracellular sites, thereby uncoupling eNOS from plasma membrane caveolae and inhibiting NO synthesis. NOSIP also interacts with protein phosphatase PP2A and mediates the monoubiquitination of the PP2A catalytic subunit. Thus, it is a critical modulator of brain and craniofacial development in mice and a candidate gene for holoprosencephaly in humans. Moreover, NOSIP associates with the erythropoietin (Epo) receptor (EpoR), mediates ubiquitination of EpoR, and plays an essential role in erythropoietin-induced proliferation. NOSIP contains an atypical N-terminal RING-like U-box domain that is split into two parts by an interjacent stretch of 104 amino acid residues, as well as a C-terminal RING-like U-box domain. This model corresponds to the first U-box domain.
Statistics
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PSSM-Id: 438323
Aligned: 22 rows
Threshold Bit Score: 70.0414
Created: 13-Apr-2015
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q9Y314        43 FDCCCLSLQPChDPVVTPDGYLYEREAILEYILHQKKEiarqmkayekqrgtrreeqkelqraasqdhvrgflekesaiv 122 human
XP_001744807  43 VDCCCLTLQPVvDGVVTPDGYLYEREAILENLLHQKREyvrqmkeyqrqverekqegleteaaahrdrieafrqaergit 122 Monosiga brevic...
KDD75552      41 FYDCRLTLRRAvDPVCTPLGYIYSREAILENLLAQKKAnkrklaaweaqqatdaakaedraeiareaellafdrvnhqga 120 Helicosporidium...
Q5U3S7        43 FDCCSLSLQPCrDPVLTEDGYLYEKEAILQYILHQKTEiakkmkayekqkqalksegqleskseereraekfkqrenniv 122 zebrafish
CCU09388      43 FDCCSLTLQPCkNPVVTVDGYLYDKEAILECLLHQKREnarrlkeyerqkqrheekefeqgreethsmvakflsteksiv 122 Suberites domun...
Q6NUH3        43 FDCCCLSLQPCkDPVVTSDGYIYEKESILEYILHQKKEiarqmkayekqknskkaemeelnkaakeskmkafldkemtiv 122 African clawed ...
XP_007910224  43 FDCCCLSLQPCkNPVVTPEGYLYEKEAILEYILHKKNEiikqvkayekqknvkktekaelakaakeskvaaflekestiv 122 elephant shark
XP_005991006  43 FDCCSLSLQPCkDPVVTPEGYLYEKEAILEYILHQKREiakkmkafekqknekkaeaqelvkaakdtkvkaflakettiv 122 coelacanth
EME32088      39 FDCCCLSLQPSkDPVVTPEGFLYDREAILEHLLNQKRSlkkveenerkrklasklqkerleqeeqrerieeferkargls 118 Galdieria sulph...
XP_004333667  39 FDWCNLTLATAvQPVVTPVGYVYSKEAIYENFLQQKKEierkkqlweeqqkrllndaqkkeddaklaevekfiksenava 118 Acanthamoeba ca...
Q9Y314       123 srplnpftak-----alsgtspddvqpgpsvgppskdkdkvlpsfwipsltpeakatklekpsrtvtCPMSGKPL 192 human
XP_001744807 123 aaqissftkddkvrthasdaldeaksrafriktakgeqeanhaafwvpqmapeasktkltkpdkktrCPTSGRPL 197 Monosiga brevicollis...
KDD75552     121 saeladrltaai-qeevdaalsdkkvtasainiqdhadrikelkafwvpsasseaetklekpsmqtlCPASGQKL 194 Helicosporidium sp. ...
Q5U3S7       123 skpinpftsgks--kdegnqngstsssstdtssgesssssalpsfwipsltpeakptllkkpsktvsCPMSGRPL 195 zebrafish
CCU09388     123 skpinpftget---tdskshdktskgqsttdsgsaedqrsklpsfwipsltpdakpteikkpdnktyCPTSGRQL 194 Suberites domuncula
Q6NUH3       123 skplnpftr--------ksdsgidaaepscsqqsseeknkqlpsfwipsltpeaktslvkkpdktvyCPMSGRPL 189 African clawed frog
XP_007910224 123 skplnpf-----------snkageqqpgpskeppaavkprslpsfwvpsltpeakaadikkpdktvyCPMSGKPL 186 elephant shark
XP_005991006 123 skplnpf------------tvkadaaqpstseegadpqgkqlpsfwipsltpeakaskirkpdkcvyCPMSGMPL 185 coelacanth
EME32088     119 ntvk------------------kpklsdsfegkdfgssncwlpeskvgqkeeivvdgekgasikytcCPMSGKPL 175 Galdieria sulphuraria
XP_004333667 119 lplpeke-----------rkrqtdrteeeelkarvrehaknlraywvpgkapsaeesllpkpsskthDPMSNDPV 182 Acanthamoeba castell...
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