Conserved Protein Domain Family
RING-HC_PCGF3
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cd16735: RING-HC_PCGF3 
RING finger found in polycomb group RING finger protein 3 (PCGF3) and similar proteins
PCGF3, also known as RING finger protein 3A (RNF3A), is one of six PcG RING finger (PCGF) homologs (PCGF1, PCGF2/Mel-18, PCGF3, PCGF4/BMI1, PCGF5, and PCGF6) and serves as the core component of a Polycomb repressive complex 1 (PRC1). Like other PCGF homologs, PCGF3 associates with ring finger protein 2 (RNF2) to form a RNF2-PCGF heterodimer, which is catalytically competent as an E3 ubiquitin transferase and is the scaffold for the assembly of additional components. PCGF3 contains a C3HC4-type RING-HC finger.
Links
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Statistics
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PSSM-Id: 438393
Aligned: 12 rows
Threshold Bit Score: 104.843
Created: 18-Mar-2015
Updated: 17-Oct-2022
Structure
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Aligned Rows:
Download Cn3D
 
Zn binding siteputative
Feature 1: Zn binding site [ion binding site], 8 residue positions
Conserved feature residue pattern:C C C H C C C CClick to see conserved feature residue pattern help
Evidence:
  • Comment:based on the structure of Homo sapiens PCGF4 with bound Zn2+ ions thorugh its RING-HC finger
  • Comment:C3HC4-type RING-HC finger consensus motif: C-X2-C-X(9-39)-C-X(1-3)-H-X(2-3)-C-X2-C-X(4-48)-C-X2-C, where X is any amino acid and the number of X residues varies in different fingers
  • Comment:A RING finger typically binds two zinc atoms, with its Cys and/or His side chains in a unique "cross-brace" arrangement.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                     #  #            # #  #  #           #  #              
Q3KNV8         4 RKIKLWDINAHITCRLCSGYLIDATTVTECLHTFCRSCLVKYLE-ENNTCPTCRIVIHQSHPLQYIG 69  human
CDQ61216      12 RKIKLWDINAHITCRLCEGYLIDATTVTECLHTFCRSCLVKYLE-ENNTCPTCRIVIHQSHPLQYIG 77  rainbow trout
Q07G17         4 RKIKLWDINAHITCRLCNGYLIDATTVTECLHTFCRSCLVKYLE-ENNTCPTCRIVIHQSHPLQYIG 69  western clawed frog
XP_007890077 112 RKIKLWDINAHITCRLCNGYLIDATTVTECLHTFCRSCLVKYLE-ENNTCPTCRIVIHQSHPLQYIG 177 elephant shark
EEC07518       3 RRIRLKTLNNHIICKICKGYLIDATTVTECLHTFCKSCLVKHLE-DNNTCPTCEIVIHQSYPLQYIS 68  black-legged tick
NP_001255620 316 VKYNMEVLNPFITCGICDGYIVDATTIIDCMHTFCKSCLLTYFEsDNNTCPTCGTFIHGSHPTHYVT 382 Caenorhabditis elegans
XP_006815559   3 RQIRLVEVNAHITCRICHGYFIDATTITECLHTFCKSCIVRYLE-EHNTCPTCGIVIHQSHPLHYIG 68  Saccoglossus kowalevskii
KOF85808       4 RRIRLKSVNVHITCTLCSGYLIDATTITECLHTFCKSCLVQYLD-DNNTCPTCEIVIHQSHPLNYIR 69  Octopus bimaculoides
XP_013399540   8 RRIRLKTVNPHITCRLCKGYLIDATTITECLHTFCKCCIVKYLE-ENNTCPTCQIVIHQSHPLNYIS 73  Lingula anatina
EFX66800       3 RKIKLRSLNSHIICKICGGYLIDATTVTECLHTFCKSCLVKHLE-ENNTCPSCNIMIHQSHPLQYIS 68  common water flea
XP_009019974  11 RKIRLKTLNPCITCMLCKGYMIEATTITECLHTFCKSCIVKFLE-ENNTCPKCGLVIHQSHPLNYIS 76  Helobdella robusta
XP_014353892   4 RKIKLWDINAHITCRLCNGYLIDATTVTECLHTFCRSCLVKYLE-ENNTCPTCRIVIHQSHPLQYIG 69  coelacanth

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