Conserved Protein Domain Family
RING-HC_RING1
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cd16739: RING-HC_RING1 
RING finger, HC subclass, found in really interesting new gene 1 protein (RING1) and similar proteins
RING1, also known as polycomb complex protein RING1, RING finger protein 1 (RNF1), or RING finger protein 1A (RING1A), was identified as a transcriptional repressor that is associated with the Polycomb group (PcG) protein complex involved in stable repression of gene activity. It is a core component of polycomb repressive complex 1 (PRC1) that functions as an E3-ubuiquitin ligase that transferring the mono-ubuiquitin mark to the C-terminal tail of Histone H2A at K118/K119. PRC1 is also capable of chromatin compaction, a function not requiring histone tails, and this activity appears important in gene silencing. RING1 interacts with multiple PcG proteins and displays tumorigenic activity. It also shows zinc-dependent DNA binding activity. Moreover, RING1 inhibits transactivation of the DNA-binding protein recombination signal binding protein-Jkappa (RBP-J) by Notch through interaction with the LIM domains of KyoT2. RING1 contains a C3HC4-type RING-HC finger.
Links
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Statistics
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PSSM-Id: 438397
Aligned: 9 rows
Threshold Bit Score: 149.846
Created: 22-Mar-2015
Updated: 17-Oct-2022
Structure
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Aligned Rows:
Download Cn3D
 
Zn binding siteoligomer
Feature 1: Zn binding site [ion binding site], 8 residue positions
Conserved feature residue pattern:C C C H C C C CClick to see conserved feature residue pattern help
Evidence:
  • Comment:based on the structure of human RING1B with bound Zn2+ ions through its RING-HC finger
  • Comment:C3HC4-type RING-HC finger consensus motif: C-X2-C-X(9-39)-C-X(1-3)-H-X(2-3)-C-X2-C-X(4-48)-C-X2-C, where X is any amino acid and the number of X residues varies in different fingers
  • Comment:A RING finger typically binds two zinc atoms, with its Cys and/or His side chains in a unique "cross-brace" arrangement.
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1             #  #            # #  #  #           #  #                         
Q06587        43 HSELMCPICLDMLKNTMTTKECLHRFCSDCIVTALRSGNKECPTCRKKLVSKRSLRPDPNFDALISKIYP 112 human
Q7ZWM8        42 HSELMCPICLDMLKNTMTTKECLHRFCSDCIVTALRSGNKECPTCRKKLVSKRSLRPDPNFDALISKIYP 111 African clawed frog
Q66J69        43 HSELMCPICLDMLKNTMTTKECLHRFCSDCIVTALRSGNKECPTCRKKLVSKRSLRPDPNFDALISKIYP 112 African clawed frog
KGL80011      20 HSELMCPICLDMLKNTMTTKECLHRFCSDCIVTALRSGNKECPTCRKKLVSKRSLRPDPNFDALISKIYP 89  Tinamus guttatus
XP_006001015  43 HSELMCPICLDMLKNTMTTKECLHRFCSDCIVTALRSGNKECPTCRKKLVSKRSLRPDPNFDALISKIYP 112 coelacanth
EFX70340      42 HSELMCPICLDMLKNTMTTKECLHRFCSDCIITALRSGNKECPTCRKKLVSKRSLRPDPNFDMLIAKIYP 111 common water flea
Q9VB08        41 HSELMCPICLDMLKKTMTTKECLHRFCSDCIVTALRSGNKECPTCRKKLVSKRSLRADPNFDLLISKIYP 110 fruit fly
ADN37676      43 HSELMCPICLDMLKNTMTTKECLHRFCSDCIVTALRSGNKECPTCRKKLVSRRSLRRDSNFDALISKIYP 112 rainbow trout
CDS31892      40 QSELMCPICLDILKVTMTTKECLHRFCSDCIVTALRNGNKECPTCRKKLVSKRSLRRDPNFDALIAKIYP 109 Hymenolepis microstoma

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