Conserved Protein Domain Family

cl00145: T-box Superfamily 
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DNA-binding domain of the T-box transcription factor family
The T-box family is an ancient family of transcription factors which plays a multitude of diverse functions throughout development. The founding member of the family is Brachyury (also known as TBXT, or T). Members share a conserved DNA-binding domain (T-box) which binds DNA in a sequence-specific manner. Common features shared by T-box family members are DNA-binding and transcriptional regulatory activity, a role in development, and conserved expression patterns. The T-box factors in Caenorhabditis elegans have evolved very differently than those in other organisms; its genome contains 22 T-box genes which encode factors which are diverse in DNA-binding specificity, function and sequence, and only 3 of these factors fall into the conserved T-box subfamilies.
Accession: cl00145
PSSM Id: 412183
Name: T-box
Created: 8-Feb-2008
Updated: 24-Nov-2020
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