Conserved Protein Domain Family
BTB

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cl02518: BTB Superfamily (this model, PSSM-Id:413352 is obsolete)
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BTB/POZ domain
The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.
Links
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Taxonomy: root
PubMed: 18 links
Protein: Related Protein
Related Structure
Statistics
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Accession: cl02518
PSSM Id: 413352
Name: BTB
Created: 8-Feb-2008
Updated: 24-Nov-2020
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