Conserved Protein Domain Family

cl02570: RhoGAP Superfamily 
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RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to GDP. The Rho family of small G proteins, which includes Cdc42Hs, activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. G proteins generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude. The RhoGAPs are one of the major classes of regulators of Rho G proteins.
Taxonomy: root
PubMed: 134 links
Protein: Related Protein
Related Structure
Accession: cl02570
PSSM Id: 413382
Name: RhoGAP
Created: 8-Feb-2008
Updated: 24-Nov-2020
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