Conserved Protein Domain Family

cl06547: Shugoshin_N Superfamily 
Shugoshin N-terminal coiled-coil region
The Shugoshin protein is found to have this conserved N-terminal coiled-coil region and a highly conserved C-terminal basic region, family Shugoshin_C pfam07557. Shugoshin is a crucial target of Bub1 kinase function at kinetochores, necessary for both meiotic and mitotic localization of shugoshin to the kinetochore. Human shugoshin is diffusible and mediates kinetochore-driven formation of kinetochore-microtubules during bipolar spindle assembly. Further, the primary role of shugoshin is to ensure bipolar attachment of kinetochores, and its role in protecting cohesion has co-developed to facilitate this process.
Taxonomy: Eukaryota
Accession: cl06547
PSSM Id: 323506
Name: Shugoshin_N
Created: 8-Feb-2008
Updated: 5-Dec-2016
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