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Domain of Unknown Function (DUF1542) This domain is found in several cell surface proteins, such as extracellular matrix-binding protein ebh. Some members are involved in antibiotic resistance (e.g Swiss:Q9RL69 and Swiss:Q9LCJ9) and/or cellular adhesion. In some proteins it is repeated more than fifteen times, being the most repeated domain in streptococci. This is a predominantly alpha-helical domain that form a long, thin, fibre-like structure and it has been proposed to function as a stalk that helps the adhesive non-repeat region (NRR) of proteins protrude beyond the cell surface. |
Jiyao W et al.(2023). "The conserved domain database in 2023.",