Conserved Protein Domain Family

cl06721: Abi_HHR Superfamily 
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Abl-interactor HHR
The region featured in this family is found towards the N-terminus of a number of adaptor proteins that interact with Abl-family tyrosine kinases. More specifically, it is termed the homeo-domain homologous region (HHR), as it is similar to the DNA-binding region of homeo-domain proteins. Other homeo-domain proteins have been implicated in specifying positional information during embryonic development, and in the regulation of the expression of cell-type specific genes. The Abl-interactor proteins are thought to coordinate the cytoplasmic and nuclear functions of the Abl-family kinases, and seem to be involved in cytoskeletal reorganisation, but their precise role remains unclear.
Taxonomy: Bilateria
Accession: cl06721
PSSM Id: 323581
Name: Abi_HHR
Created: 8-Feb-2008
Updated: 5-Dec-2016
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