Conserved Protein Domain Family

cl07578: Transglut_prok Superfamily 
Microbial transglutaminase
Microbial transglutaminase (MTG) catalyzes an acyl transfer reaction by means of a Cys-Asp diad mechanism, in which the gamma-carboxyamide groups of peptide-bound glutamine residues act as the acyl donors. The MTG molecule forms a single, compact domain belonging to the alpha+beta folding class, containing 11 alpha-helices and 8 beta-strands. The alpha-helices and the beta-strands are concentrated mainly at the amino and carboxyl ends of the polypeptide, respectively. These secondary structures are arranged so that a beta-sheet is surrounded by alpha-helices, which are clustered into three regions.
Taxonomy: Streptomyces
Accession: cl07578
PSSM Id: 126047
Name: Transglut_prok
Created: 8-Feb-2008
Updated: 19-Sep-2018
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