Conserved Protein Domain Family

cl09931: NADB_Rossmann Superfamily (this model, PSSM-Id:263925 is obsolete)
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Rossmann-fold NAD(P)(+)-binding proteins
A large family of proteins that share a Rossmann-fold NAD(P)H/NAD(P)(+) binding (NADB) domain. The NADB domain is found in numerous dehydrogenases of metabolic pathways such as glycolysis, and many other redox enzymes. NAD binding involves numerous hydrogen-bonds and van der Waals contacts, in particular H-bonding of residues in a turn between the first strand and the subsequent helix of the Rossmann-fold topology. Characteristically, this turn exhibits a consensus binding pattern similar to GXGXXG, in which the first 2 glycines participate in NAD(P)-binding, and the third facilitates close packing of the helix to the beta-strand. Typically, proteins in this family contain a second domain in addition to the NADB domain, which is responsible for specifically binding a substrate and catalyzing a particular enzymatic reaction.
Taxonomy: root
PubMed: 382 links
Protein: Related Protein
Related Structure
Accession: cl09931
PSSM Id: 263925
Name: NADB_Rossmann
Created: 2-Apr-2008
Updated: 16-Jan-2014
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