Conserved Protein Domain Family

cl10015: YjgF_YER057c_UK114_family Superfamily 
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YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no functional connection. Members of this family have been implicated in isoleucine (Yeo7, Ibm1, aldR) and purine (YjgF) biosynthesis, as well as threonine anaerobic degradation (tdcF) and mitochondrial DNA maintenance (Ibm1). This domain homotrimerizes forming a distinct intersubunit cavity that may serve as a small molecule binding site.
Accession: cl10015
PSSM Id: 415826
Name: YjgF_YER057c_UK114_family
Created: 6-Oct-2008
Updated: 24-Nov-2020
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