Conserved Protein Domain Family

cl14648: Aldose_epim Superfamily 
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aldose 1-epimerase superfamily
Aldose 1-epimerases or mutarotases are key enzymes of carbohydrate metabolism; they catalyze the interconversion of the alpha- and beta-anomers of hexose sugars such as glucose and galactose. This interconversion is an important step that allows anomer specific metabolic conversion of sugars. Studies of the catalytic mechanism of the best known member of the family, galactose mutarotase, have shown a glutamate and a histidine residue to be critical for catalysis; the glutamate serves as the active site base to initiate the reaction by removing the proton from the C-1 hydroxyl group of the sugar substrate and the histidine as the active site acid to protonate the C-5 ring oxygen.
Accession: cl14648
PSSM Id: 449342
Name: Aldose_epim
Created: 27-Dec-2010
Updated: 8-Mar-2022
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