Conserved Protein Domain Family

cl15348: RING Superfamily (this model, PSSM-Id:214238 is obsolete)
RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in mediating protein-protein interactions; identified in a proteins with a wide range of functions such as viral replication, signal transduction, and development; has two variants, the C3HC4-type and a C3H2C3-type (RING-H2 finger), which have different cysteine/histidine pattern; a subset of RINGs are associated with B-Boxes (C-X2-H-X7-C-X7-C-X2-C-H-X2-H)
Taxonomy: root
PubMed: 51 links
Protein: Related Protein
Related Structure
Accession: cl15348
PSSM Id: 214238
Name: RING
Created: 31-Aug-2011
Updated: 29-Oct-2012
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