?cl19745: Ins145_P3_rec Superfamily (this model, PSSM-Id:450353 is obsolete)
Inositol 1,4,5-trisphosphate/ryanodine receptor This domain corresponds to the ligand binding region on inositol 1,4,5-trisphosphate receptor, and the N terminal region of the ryanodine receptor. Both receptors are involved in Ca2+ release. They can couple to the activation of neurotransmitter-gated receptors and voltage-gated Ca2+ channels on the plasma membrane, thus allowing the endoplasmic reticulum discriminate between different types of neuronal activity.
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Jiyao W et al.(2023). "The conserved domain database in 2023.",