Conserved Protein Domain Family

cl20088: EF-hand_2 Superfamily 
EF hand
Members of this family adopt a helix-loop-helix motif, as per other EF hand domains. However, since they do not contain the canonical pattern of calcium binding residues found in many EF hand domains, they do not bind calcium ions. The main function of this domain is the provision of specificity in beta-dystroglycan recognition, though in dystrophin it serves an additional role: stabilisation of the WW domain (pfam00397), enhancing dystroglycan binding.
Taxonomy: Eumetazoa
Accession: cl20088
PSSM Id: 418763
Name: EF-hand_2
Created: 16-Jan-2014
Updated: 24-Nov-2020
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