Conserved Protein Domain Family

cl20817: GBP_C Superfamily 
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Guanylate-binding protein, C-terminal domain
Guanylate-binding protein (GBP), C-terminal domain. Guanylate-binding proteins (GBPs) are synthesized after activation of the cell by interferons. The biochemical properties of GBPs are clearly different from those of Ras-like and heterotrimeric GTP-binding proteins. They bind guanine nucleotides with low affinity (micromolar range), are stable in their absence, and have a high turnover GTPase. In addition to binding GDP/GTP, they have the unique ability to bind GMP with equal affinity and hydrolyze GTP not only to GDP, but also to GMP. This C-terminal domain has been shown to mediate inhibition of endothelial cell proliferation by inflammatory cytokines.
Accession: cl20817
PSSM Id: 450829
Name: GBP_C
Created: 16-Jan-2014
Updated: 8-Mar-2022
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