Conserved Protein Domain Family
PUFD_like

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cl21640: PUFD_like Superfamily 
PCGF Ub-like fold discriminator and related domains
The PUFD domain binds the RAWUL (RING finger and WD40-associated ubiquitin-like) domain of the polycomb-group RING finger homologs PCGF1 and PCGF3. PUFD was characterized as a domain of the BCL6 corepressor BCOR. It does not appear to bind to PCGF2 and PCGF4. PCGF1 is a component of the Polycomb group (PcG) multi-protein BCOR complex, which is involved in repressing the transcription of BCL6 and CDKN1A. The BCL-6 corepressor (BCOR) is a transcriptional repressor required for germinal center formation and is possibly involved in apoptosis.
Links
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Taxonomy: Metazoa
PubMed: 9 links
Protein: Related Protein
Related Structure
Statistics
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Accession: cl21640
PSSM Id: 473927
Name: PUFD_like
Created: 5-Sep-2014
Updated: 4-Oct-2023
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