Conserved Protein Domain Family

cl23717: crotonase-like Superfamily 
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Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase. Many of these play important roles in fatty acid metabolism. In addition to a conserved structural core and the formation of trimers (or dimers of trimers), a common feature in this superfamily is the stabilization of an enolate anion intermediate derived from an acyl-CoA substrate. This is accomplished by two conserved backbone NH groups in active sites that form an oxyanion hole.
Taxonomy: root
PubMed: 78 links
Protein: Related Protein
Related Structure
Accession: cl23717
PSSM Id: 355015
Name: crotonase-like
Created: 2-Feb-2016
Updated: 19-Sep-2018
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