Conserved Protein Domain Family
FOXO-TAD

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cl25036: FOXO-TAD Superfamily 
Transactivation domain of FOXO protein family
TAD is a promiscuous binding domain that mediates the association of the transcription factor FOXO with the coactivator CBP/p300. Both this domain and the FOXO-KIX_bd family pfam16675 bind simultaneously the KIX domain of CBP/p300. Coactivator CBP/p300 is recruited by FOXO3 though binding to these two regions. The promiscuity of the TAD is further evidenced by that the finding that they also bind the TAZ1 and TAZ2 domains of CBP/p300.
Links
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Taxonomy: Bilateria
Statistics
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Accession: cl25036
PSSM Id: 452217
Name: FOXO-TAD
Created: 2-Feb-2016
Updated: 8-Mar-2022
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