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Bcl-2-binding component 3, p53 upregulated modulator of apoptosis PUMA (p53 upregulated modulator of apoptosis) is a family of eukaryotic proteins that are a target for activation by p53. The proteins contain BH3 domains and are induced in cells after p53 activation. They bind to Bcl-2, localize to the mitochondria to induce cytochrome c release, and activate the rapid induction of apoptosis. |
Jiyao W et al.(2023). "The conserved domain database in 2023.",