Conserved Protein Domain Family

cl37793: EF-hand_3 Superfamily 
Members of this family adopt a helix-loop-helix motif, as per other EF hand domains. However, since they do not contain the canonical pattern of calcium binding residues found in many EF hand domains, they do not bind calcium ions. The main function of this domain is the provision of specificity in beta-dystroglycan recognition, though in dystrophin it serves an additional role: stabilisation of the WW domain (pfam00397), enhancing dystroglycan binding.
Taxonomy: Eumetazoa
Accession: cl37793
PSSM Id: 422166
Name: EF-hand_3
Created: 19-Sep-2018
Updated: 24-Nov-2020
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