1KTH,4BQD,1ZR0,3GYM,3L33,5H7V,5H7V,4U32


Conserved Protein Domain Family
Kunitz_BPTI
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pfam00014: Kunitz_BPTI 
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Kunitz/Bovine pancreatic trypsin inhibitor domain
Indicative of a protease inhibitor, usually a serine protease inhibitor. Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure. Certain family members are similar to the tick anticoagulant peptide (TAP). This is a highly selective inhibitor of factor Xa in the blood coagulation pathways. TAP molecules are highly dipolar, and are arranged to form a twisted two- stranded antiparallel beta-sheet followed by an alpha helix.
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Statistics
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PSSM-Id: 425421
Aligned: 99 rows
Threshold Bit Score: 48.0218
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
1KTH_A    4 ICKLPK-DEG--T-CRdFI---LKWYYDPNTKSCARFWYGGCGGN--ENKFGSQKECEKVCA 56   human
P00978  286 ACNLPI-VQG--P-CRsYI---QLWAFDAVKGKCVRFSYGGCKGN--GNKFYSEKECKEYCG 338  cattle
Q94164   22 RCSKSIfDSNltAkCE-KSs-tIKFHFDQSTGLCMNFRWDGCKDQ--ENKFDSLQECASTCL 79   Caenorhabditis elegans
P48307   95 VCRLQV-SVDd-Q-CEgST---EKYFFNLSSMTCEKFFSGGCHRNriENRFPDEATCMGFCA 150  human
Q19021  254 VCNMPR-NSGv-Q-CAsSMkssNRYYFDIGTATCRSFKFTQCGGN--ANNFGSLEECEGFCV 310  Caenorhabditis elegans
O45881 1787 LCIQPV-VKG--S-CQeAH---LRYYYDRVTDSCRLFEYSGCDGN--ANNFGSLEDCQRLCV 1839 Caenorhabditis elegans
O76840 1149 RCYLPR-VDGplR-CDqLQ---PRYYYDHSKKHCVAFWWRGCLGN--ANNFNSFEECSMFCK 1203 Caenorhabditis elegans
O16701  146 ICSLPL-AVG--S-CTaPA---VRFYYDASSGRCNQFMYSGCGGN--ANNFQSLSSCQGTCG 198  Caenorhabditis elegans
O76840 1730 LCMLPE-QRG--S-CYdNI---LRWRFDSEKSQCVTFMYSGCNPN--ANHFTSQETCERACG 1782 Caenorhabditis elegans
O95428  753 RCLLPS-AHG--S-CAdWA---ARWYFVASVGQCNRFWYGGCHGN--ANNFASEQECMSSCQ 805  human
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