5UOH,2B61,5T6O,2PSJ,3WK8,1M33


Conserved Protein Domain Family
Abhydrolase_1

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pfam00561: Abhydrolase_1 
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alpha/beta hydrolase fold
This catalytic domain is found in a very wide range of enzymes.
Statistics
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PSSM-Id: 395444
Aligned: 48 rows
Threshold Bit Score: 91.0269
Created: 21-Mar-2022
Updated: 13-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
5UOH_A                74 GSLVINPGGPGes----------giEAAlgVFQTLPKRvh-------eRFDLVGFDPRGVASSRPAIWCnsdadndrlra 136 Mycobac...
2B61_A                60 NAVLICHALTGdaepyf--ddgrdgWWQnfXGAGLALDt--------dRYFFISSNVLGGCKGTTGPSSinpqtgk---- 125 Haemoph...
Q10341               117 NAILLHTGLSAsshahshpentapgWWEqfIGPGKDVDt--------nKFFVICTNVLGSCYGSTGPSSvdpgdgk---- 184 Schizos...
XP_018890104          80 PVVFLQHGLLAds----------snWVTnlANSSLGFIla------daGFDVWMGNSRGNTWSRKHKTLsvsqdefw--- 140
P34163               106 KVVYLHHGLLMcs----------dvWCC-----NIERHknlpfvlhdlGYDVWMGNNRGNKYSTAHLNKppksnkfw--- 167 Sacchar...
P08658                 9 YPILLVHGLFGfdrig-----shhyFHG--IKQALNEC----------GASVFVPIISAANDNEARGDQ----------- 60  Pseudom...
P26877                34 YPIVLAHGMLGfdnil-----gvdyWFG--IPSALRRD----------GAQVYVTEVSQLDTSEVRGEQ----------- 85  Pseudom...
goetting:BGL_2c18660  48 YPVILVHGLAGtdkfa----nvvdyWYG--IQSDLQSH----------GAKVYVANLSGFQSDDGPNgr----------- 100
P45370                68 VPLLIVYALVNrpym-------tdiQEDrsTIKGLLAT----------GQDVYLIDWGYPDQADRALTLdd--------- 121 Allochr...
5T6O_A                39 PLLMVPPCINKyyi--------ldlQPEssLVRHVVEQ----------GHTVFLVSWRNPDASMAGSTWdd--------- 91  Cupriav...
5UOH_A               137 epqvdysregvahienetkqfvgrcvdkmgknflahvGTVNVAKDLD--AI--RAALGDDKLT-YLGYSYGTRIGSAYAE 211 Mycobac...
2B61_A               126 -------------------------------pygsqfPNIVVQDIVKvqKAl-LEHLGISHLKaIIGGSFGGXQANQWAI 173 Haemoph...
Q10341               185 -------------------------------hyatrfPIITVNDMIRa-QLllLDHLKIEKLYaSVGSSLGGMQSLTLGA 232 Schizos...
XP_018890104         141 ------------------------------afsydemAKYDLPASIN--FI--LNKTGQEQVY-YVGHSQGTTIGFIAFS 185
P34163               168 ------------------------------dfsidefAFFDIPNSIE--FI--LDITKVDKVI-CIGFSQGSAQMFAAFS 212 Sacchar...
P08658                61 -----------------------------------------LLKQIH--NL--RRQVGAQRVN-LIGHSQGALTARYVAA 94  Pseudom...
P26877                86 -----------------------------------------LLQQVE--EI--VALSGQPKVN-LIGHSHGGPTIRYVAA 119 Pseudom...
goetting:BGL_2c18660 101 ------------------------------------gEQ--LLAYVK--QV--LAATGATKVN-LIGHSQGGLTSRYVAA 137
P45370               122 ------------------------------------yINGYIDRCVD--YL--REAHGVDKVN-LLGICQGGAFSLMYSA 160 Allochr...
5T6O_A                92 ------------------------------------yIEHAAIRAIE--VA--RDISGQDKIN-VLGFAVGGTIVSTALA 130 Cupriav...
5UOH_A               212 EF----PQrVRAMILDGAvdp-------nadPIEAELRQAKGFQDAFNNYAADCAKNAGCPLGADPAKAVEVYHSLVDPL 280 Mycobac...
2B61_A               174 DY----PDfXDNIVNLCSsiyfs---aeaigFNHVXRQAVINDPNFNGGDYYEGTPPDQGLSIARXLGXLTYRTDLQLAK 246 Haemoph...
Q10341               233 LA----PHrVGRIASISGgarsh---pysiaLRFTQRQILMNDPYWNRGFYYDGVPPHTGMKLAREVATISYRSG----- 300 Schizos...
XP_018890104         186 QIpe-lAKrIKMFFALGPvasvafctspmakLGRLPDHLIKDLFGDKEFLPQSAFLKWLGTHVCTHVILKELCGNLCFLL 264
P34163               213 LSek-lNRkVSHFIAIAPamtp------kglHNRIVDTLAKSSPGFMYLFFGRKIVLPSAVIWQRTLHPTLFNLCIDIAN 285 Sacchar...
P08658                95 IA----PElIASVTSVSGpn---------hgSELADRLRLAFVPGRLGETVAAALTTSFSAFLSALSGHPRLPQNALNAL 161 Pseudom...
P26877               120 VR----PDlMPSATSVGAph----------kGSDTADFLRQIPPGSAGEAVLSGLVNSLGALISFLSSGSAGTQNSLGSL 185 Pseudom...
goetting:BGL_2c18660 138 VA----PQlVASVTTIGTphr-------gseFADFVQDVLKTDPTGLSSTVIAAFVNVFGTLVSSSHNTDQDALAALRTL 206
P45370               161 LH----PDkVRNLVTMVT--------------PVDFKTPDNLLSAWVQNVDIDLAVDTMGNIPGELLNWTFLSLKPFSLT 222 Allochr...
5T6O_A               131 VLaargEHpAASVTLLTTlld-------fadTGILDVFVDEGHVQLREATLGGGAGAPCALLRGLELANTFSFLRP---- 199 Cupriav...
5UOH_A               281 vdpdnprisrpartkdprglsysdaivgtimalyspnlwqhltdglselvdnrgdtllalADMYMRRDSHGRYNNSGDAR 360 Mycobac...
2B61_A               247 afg-------------------------------------------------------raTKSDGSFWGDYFQVESYLSY 271 Haemoph...
Q10341               301 ------------------------------------------------------------PEWEQRFGNRRADPSVSPAF 320 Schizos...
XP_018890104         265 cg---------------------------------------------------------fNERNLNMSRVDVYTTHSPAG 287
P34163               286 kil------------------------------------------------------fnwKSFNILPRQKIASYAKLYST 311 Sacchar...
P08658               162 n----------------------------------------------------------aLTTDGVAAFNRQYPQGLPDR 183 Pseudom...
P26877               186 esln----------------------------------------------------segaARFNAKYPQGIPTSACGEGA 213 Pseudom...
goetting:BGL_2c18660 207 tta-------------------------------------------------------qtATYNRNFPSAGLGAPGSCQT 231
P45370               223 gqkyvnm-----------------------------------------------vdllddPDKVKNFLRMEKWIFDSPDQ 255 Allochr...
5T6O_A               200 ------------------------------------------------------------NDLVWNYVVDNYLKGNTPVP 219 Cupriav...
5UOH_A               361 VAINCVDQPPVTDRDKVIDEDRRareiapfmsygkftgdaplgtcafwpvpptsqphavsapglvPTVVVST----THDP 436 Mycobac...
2B61_A               272 QGKKFLERFDANSYLHLLRALDXydpslgyenv-----------------------kealsrikaRYTLVSV----TTDQ 324 Haemoph...
Q10341               321 CPDFLIETYLDHAGEKFCLQYDP------------------------------------------NSLLYISkamdMHDM 358 Schizos...
XP_018890104         288 TSVQNMLHWSQAVKFQKFQAFDWgssaknyfhynqs-----------------ypptynvkdmlvPTAVWSG----GHDW 346
P34163               312 TSVKSIVHWFQILRSQKFQMFEEsdnmlnsltrpyq-----------------ianfptrtnikiPILLIYG----GIDS 370 Sacchar...
P08658               184 WGGMGPAQVNAVHYYSWSGIIKG------------------------------------------SRLAE------SLNL 215 Pseudom...
P26877               214 YKVNGVSYYSWSGSSPLTNFLD-------------------------------------------PSDAFLG----ASSL 246 Pseudom...
goetting:BGL_2c18660 232 GAATETVGGSQHLLYSWGGTAIQptstvlgvtgatd----------------tstgtldvanvtdPSTLALL----ATGA 291
P45370               256 AGETFRQFIKDFYQNNGFLNGGVvlggqev----------------------------dlkditcPVLNIFA----LQDH 303 Allochr...
5T6O_A               220 FDLLFWNGDATNLPGPWYCWYLRhtylqnelkvpgkl--------------tvcgvpvdlasidvPTYIYGS----REDH 281 Cupriav...
5UOH_A               437 AAPY-KAGVDLANQ---LRG------SLLTFDGTQHTVVFQGD 469 Mycobacterium tuberculosis H37Rv
2B61_A               325 LFKP-IDLYKSKQL---LEQsgvdlhFYEFPSDYGHDAFLVDY 363 Haemophilus influenzae
Q10341               359 SASHqRSLSENRKKnqhKLDk-----YLSADVSAEEIIKLNED 396 Schizosaccharomyces pombe 972h-
XP_018890104         347 LADVyDVNILLTQI---TNLv-----FHESIPEWEHLDFIWGL 381
P34163               371 LVDIdVMKKNLP-----FNSv-----FDVKVDNYEHLDLIWGK 403 Saccharomyces cerevisiae S288C
P08658               216 LDPLhNALRVFDSF---FTRe-----TRENDGMVGRFSSHLGQ 250 Pseudomonas fragi
P26877               247 TFKNgTANDGLVGT---CSSh-----LGMVIRDNYRMNHLDEV 281 Pseudomonas sp. 109
goetting:BGL_2c18660 292 VMIN-RASGQNDGLvsrCSSl-----FGQVISTSYHWNHLDEI 328
P45370               304 LVPP-DASRALKGLt-sSPD------YTELAFPGGHIGIYVSG 338 Allochromatium vinosum DSM 180
5T6O_A               282 IVPW-TAAYASTAL---LANk-----LRFVLGASGHIAGVINP 315 Cupriavidus necator
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