6P7J


Conserved Protein Domain Family
TGFb_propeptide

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pfam00688: TGFb_propeptide 
TGF-beta propeptide
This propeptide is known as latency associated peptide (LAP) in TGF-beta. LAP is a homodimer which is disulfide linked to TGF-beta binding protein.
Statistics
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PSSM-Id: 395559
Aligned: 66 rows
Threshold Bit Score: 111.578
Threshold Setting Gi: 575773383
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
6P7J_A         1 LSTCKTIDMELVKRKRIEAIRGQILSKLRLASPPSQgev-ppGPLPEAVLALYNST-------------RDRVAGES--- 63 
XP_015196176  23 LSTCKPLDLELAKRKRIEAIRGQILSKLRMSREPKEeep-plEPEP-EVLSVYNST-------------KELSEEQArqa 87  spotted gar
XP_025753606  20 LSTCNTVDLEMVKKKRIEAIRSQILTKLRLQKAPDEag--ekEEIPANLLSLYNST-------------SEILLEKQdee 84  Nile tilapia
NP_001266976  20 MSTCKTLDLEMVKKKRIEAIRSQILSKLRLPKEPEPdqsqdeENIPTPLLSLYDSV-------------KEMLKEQRted 86  torafugu
XP_003222953  48 LSTCKTLDMDMMKRKRIEAIRGQILSKLKLSKPPEVedp-dsRVLSDEIMALYNST-------------LEVIRERVaed 113 green anole
P09531        19 lSTCQRLDLEAAKKKRIEAVRGQILSKLRLTAPPPAset-ppRPLPDDVRALYNST-------------QELLKQRArlr 84  chicken
XP_007492045  29 MSTCKTLDMELVKRRRIEAIRGQILSKLRLDSPPAQsev-ppGPLPDAVLALYNST-------------RDRVVPESv-- 92  gray short-tail...
XP_003997823  30 LSTCKTIDMELVKRKRIEAIRGQILSKLRLASPPSQgev-ppGPLPEAVLALYNST-------------RDRVAGESaep 95  domestic cat
XP_014323463  30 LSTCKTIDMEMVKRKRIEAIRGQILSKLRLTEAPSPgev-psGPLPERGNAPFTTPmmeekgfreeetnPERASHSSkvr 108 little brown bat
CAG12751      20 MSTCKTLDLEMVKKKRIEAIRSQILSKLRLPKEPEPdqdkdgGEIPTPLLSLYNST-------------KEMLNEQQtqg 86  spotted green p...
6P7J_A        64 --AEP-EPEpeADYYAKEVT----------RVL-----------MV------ETH--NeiYDKFKQSTHSIYMFFNTSEl 111
XP_015196176  88 etSPAaQHGeqEEYFGKEVH----------KFI-----------MK------NNEsnQ--GEK----KYVKELLFNTSE- 133 spotted gar
XP_025753606  85 qkIIP-REQeeEEYFAKVLN----------RFN-----------MTt-----KNDtnI--NYK----PKVISMSFNISE- 130 Nile tilapia
NP_001266976  87 qtRIS-VEQeeMEYFAKVPH----------KFN-----------MS------INStaI--MGN----KN-VAVPFNISE- 130 torafugu
XP_003222953 114 pkE-----TpqEEYYAKEIH----------RFN-----------MLp-----LNHesY--GEQYKKNLYRTFFGFNLSQ- 159 green anole
P09531        85 pp-----pdgpDEYWAKELR----------RIP-----------ME------TTWdgP--MEHWQPQSHSIFFVFNVSR- 129 chicken
XP_007492045  93 -------pEaeTDYYAKEVT----------RVL-----------MLp-----QNPd-------VEKSPHSLYFHFNTSQ- 131 gray short-tail...
XP_003997823  96 ------epEpeADYYAKEVT----------RVL-----------MV------ENTnkI--YEKVQRTPHSIYMLFNTSE- 139 domestic cat
XP_014323463 109 ------vgLqpRRSALEPMLftlgvhqlpcHCH-----------TPdipllhSFCleI--YKKFKHNSHSIYMFFNTSD- 168 little brown bat
CAG12751      87 qtRLS-TEQeeMEYFSKVLH----------RFFkkklfslyiffIS-------NPenA---------KKVIAMSVDISE- 138 spotted green p...
6P7J_A       112 reaV----PEPVLLSR-----AELRLLRLKLKVEQHVELYQKY----SNNSWRYLSNRLLaPSDSPEWLSFDVTGVVRQW 178
XP_015196176 134 ---MrrslGEGRLVTQaelrlFvktvfm-epgneqRLDLYKC-----KGNKTHYLNSRTVsKASQDTWLSFDVTETVREW 204 spotted gar
XP_025753606 131 ---IrsnvGDGLLLTRaelrmLikepm---ilneeRVELYHS-----QGTSTHYLASRFVtNTLKDKWLSFDVTEPLQTW 199 Nile tilapia
NP_001266976 131 ---IrqsvGKYHQLTSaelriHikkpm---iledqRVELYYG-----LDPSARYLTTRLInNKMKDKWISFDVTEPLRKW 199 torafugu
XP_003222953 160 ---IlttlQDPKLLYRaelrmRasgks----qeqqRLELYQQQnhfsNMSNWYYLDSRLVkFKEEKEWLSFDVTSVLRVW 232 green anole
P09531       130 ---VraevGGRALLHRaelrmLRQKAAADSAGTEQRLELYQGY----GNASWRYLHGRSVrATADDEWLSFDVTDAVHQW 202 chicken
XP_007492045 132 ---LqeavPNPALLSRaelrlMktks-----aeeqHVELYQKH----GNGSWRYLTSQRVrASQSMEWLSFDVTNVVHEW 199 gray short-tail...
XP_003997823 140 ---LreavPEPVLLSRaelrlLrlkl-----kaeqHVELYQKY----SNNSWRYLSNRLLaPSDTPEWLSFDVTGVVRQW 207 domestic cat
XP_014323463 169 ---LreavPEPHLLFRaelrlQrhkl-----kvgqHVELYQKY----SNNSWRYLSNQVLdSGDTPEWLSFEVTTVVRQW 236 little brown bat
CAG12751     139 ---MrqsiGEYHLLTSaelrmFiketr---iqtekRVELYYG-----LGASARYLATRFInNKMKKTWLSFDVTEPLQNW 207 spotted green p...
6P7J_A       179 LSRGGEIEGFRLSAHC----ScdsRDNT-LQVDINGFt---------TgrRGdlatiHGMNRPFLLLM 232
XP_015196176 205 LALSEEEQKLELTLFCg--cNt--DNPE-FQFSILGFdktrg-dmkiI--SK-----QTSKSPhilvm 259 spotted gar
XP_025753606 200 LQGNENEQKFELRRYCe--cG---NNDDtLSFSISGTmsrrg-dtkdL--QK-----LNQQLPYIFTm 254 Nile tilapia
NP_001266976 200 LETSDDEQGFQLRLFCe--cSk--TTEDsFSFYIDGFsserg-dtgvV--QQ-----LTQQPPYILTM 255 torafugu
XP_003222953 233 LASGDELGRFRLCAHCs--cEg--RPEE-LKMQVEGTktkrg-dqelL--SQ-----EKQQLPYLLVm 287 green anole
P09531       203 LSGSELLGVFKLSVHCpcemGp-gHADE-MRISIEGFeqqrg-dmqsI--AK-----KHRRVPYV--L 258 chicken
XP_007492045 200 LSSKEKTETFRLSAHCs--cD---QKDTqLHMDVSGLnnlrg-dmgvI---------HNQNRPFLLLM 252 gray short-tailed opossum
XP_003997823 208 LSHGGEVEGFRLSAHCs--cD---SKDNtLQVDINGFsssrrgdlatI---------HGMNRPFLLLM 261 domestic cat
XP_014323463 237 LNYKGEIQGFRLSAHCs--cD---SKDDtLHVEINGIsmgrrgdlatI---------HGMNRPFLLLM 290 little brown bat
CAG12751     208 LKGNDNKQVFQLRAFCd--cSq--VTECvLDFDIDGKsvnre-dtgrL--KE-----MTKQPPYILTM 263 spotted green pufferfish
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