5V3P,3ZRH


Conserved Protein Domain Family
OTU

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pfam02338: OTU 
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OTU-like cysteine protease
This family is comprised of a group of predicted cysteine proteases, homologous to the Ovarian tumor (OTU) gene in Drosophila. Members include proteins from eukaryotes, viruses and pathogenic bacterium. The conserved cysteine and histidine, and possibly the aspartate, represent the catalytic residues in this putative group of proteases.
Statistics
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PSSM-Id: 396767
View PSSM: pfam02338
Aligned: 14 rows
Threshold Bit Score: 107.151
Threshold Setting Gi: 75023271
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
5V3P_A              98 NGDGNXLMHATSQYMwgvQDtdlVLRKALFSTLKETDTRNFKfrwqleslksQEFVETGLCYDTR--------------- 162 human
Q8N6M0             153 PSDGHCMYKAIEDQL---KE---KDCALTVVALRSQTAEYMQ----------SHVEDFLPFLTNPntgdmytpeef---q 213 human
Q9VUN9             178 PSDGDCLYQSIRHQLivnA-----LPGHSVQELREETANYVR----------AHKDSLISYMIHPetgdilndqqf---e 239 fruit fly
Q9LYC7             187 KPDGHCLYRAVENQLanrSG---GASPYTYQNLREMAASYMR----------EHKTDFLPFFLSEtegdsnsgsaeerfe 253 thale cress
WGS:AAAA:OsI_17444 180 kPDGHCLYRAVENQLslySR---ETTQYNYQELRQMTANYMK----------EHAADFLPFFLSEgkvesgpdples-fk 245 long-grai...
Q19681             173 PADGDCMYNAISHQL---QE---EGIEISVRKLRKRCGTYMR----------EHSEDFRPFIEDManmdsdsswaty-lg 235 Caenorhab...
P38747             173 QPDGHCLFASILDQLklrHDpkkLDQDMDVMKLRWLSCNYVQ----------EHRDDFIPYLFDEetmkmkdide----- 237 Saccharom...
Q9UUK3             191 PADGNCLFASISHQLnyhH-----NVKLNSQALRNKSADYVL----------KHCEQFEGFLLDEesgevlpvsd----- 250 Schizosac...
Q9CUB6             288 IPDGNCLYRAVSKTVy--------GDQSLHRELREQTVHYIA----------DHLDHFSPLIEGDvgefii--------- 340 house mouse
Q8I2S5              99 IGDGNCLFRSISRNLf--------HKQKYHMYVRKKCVEYMI----------NYKEEYSIYFENNefqqyik-------- 152 Plasmodiu...
5V3P_A             163 ----------NWNDewdnlikmastdtpmarsglqynsleEIHIFVLCNILRRPIIVisdkmLRSlESGSN---FAPlKV 229 human
Q8N6M0             214 kycedivntaAWGG--------------------------QLELRALSHILQTPIEI-----IQA-DSPPI---IVG-EE 257 human
Q9VUN9             240 qychdiakthAWGG--------------------------HIELKAISSLLRVPIEV-----IQA-EGAPT---LLGqEE 284 fruit fly
Q9LYC7             254 kycrevestaAWGS--------------------------QLELGALTHCLRKHIKV-----YSG-SFPDV---EMG-KE 297 thale cress
WGS:AAAA:OsI_17444 246 ryceevestaAWGG--------------------------QLELGALTHCLKKHIVV-----YSG-SFPDV---EMG-KE 289 long-grai...
Q19681             236 gvenvaeiggVWGG--------------------------ELELKACSMIFEKTIVV-----YKQ-YGGRH---TIG-EE 279 Caenorhab...
P38747             238 -ytkemehtaQWGG--------------------------EIEILALSHVFDCPISI-----LMS-GRPI--------QV 276 Saccharom...
Q9UUK3             251 -ycneirnnsKWGS--------------------------DIEIQALANSLEVPVHV-----YNT-EGPVL---KFNpST 294 Schizosac...
Q9CUB6             341 ----aaaqdgAWAG--------------------------YPELLAMGQMLNVNIHL-------T-TGGRLespTVStMI 382 house mouse
Q8I2S5             153 ----nmskngYWGD--------------------------ELCIKATADAFDCIIYI-------I-TSTLE---NWHlKY 191 Plasmodiu...
5V3P_A             230 GGiylplhwPAQECYRYPIVLGYDSHHF 257 human
Q8N6M0             258 YS-------KKPLILVYMRHAYGLGEHY 278 human
Q9VUN9             285 FG-------GSPLIICYHRHIYQLGAHY 305 fruit fly
Q9LYC7             298 YRsg----dDSSLMLSYHRHAFGLGEHY 321 thale cress
WGS:AAAA:OsI_17444 290 YKldsggkdGPSIRLSYHRHAYGLGEHY 317 long-grained rice
Q19681             280 YSsp----kDRALRVVFLRHAYSLGEHY 303 Caenorhabditis elegans
P38747             277 YNec---gkNPELKLVYYKHSYALGEHY 301 Saccharomyces cerevisiae S288C
Q9UUK3             295 VKf------EKPLCIAYYQHLFGLGAHY 316 Schizosaccharomyces pombe 972h-
Q9CUB6             383 HYlgpedslRPSIWLSWLS-----NGHY 405 house mouse
Q8I2S5             192 ESknnngmyKKCVFLAYSS-----PTHY 214 Plasmodium falciparum 3D7
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