7EEB


Conserved Protein Domain Family
OATP

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pfam03137: OATP 
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Organic Anion Transporter Polypeptide (OATP) family
This family consists of several eukaryotic Organic-Anion-Transporting Polypeptides (OATPs). Several have been identified mostly in human and rat. Different OATPs vary in tissue distribution and substrate specificity. Since the numbering of different OATPs in particular species was based originally on the order of discovery, similarly numbered OATPs in humans and rats did not necessarily correspond in function, tissue distribution and substrate specificity (in spite of the name, some OATPs also transport organic cations and neutral molecules). Thus, Tamai et al. initiated the current scheme of using digits for rat OATPs and letters for human ones. Prostaglandin transporter (PGT) proteins are also considered to be OATP family members. In addition, the methotrexate transporter OATK is closely related to OATPs. This family also includes several predicted proteins from Caenorhabditis elegans and Drosophila melanogaster. This similarity was not previously noted. Note: Members of this family are described (in the Swiss-Prot database) as belonging to the SLC21 family of transporters.
Statistics
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PSSM-Id: 460821
Aligned: 208 rows
Threshold Bit Score: 364.985
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
7EEB_L                95 GFMTLYVAAVLIHGALFAVVDMTLNIYQVQFSLTRTEWYLMDFSDYIASFVVAIIIAHFGSKGNRTRWIAASCILMGLES 174 
XP_011052736          51 LFVGLICWIGVVQAASYAYFHVTGSTIARRFQIDPYIMDWILVTAELTPIVLGLVIAYWGDKIHRASWIGALTLLQSVAH 130 
WGS:AAQB:GK20834-PA   54 MYVTLYGIAGCTIAMTFAYFNGTITTLEKRYKIPTQMSGIISVGNDMSTMFASALLGYYAGSGHRCRWMGVGLLTFVIFC 133 
EEC20306               6 AFLAVFCLTSVLQGMYYTYFVSVLTTIEKLYQIPSKTTGIIMSATEIGQIGGALLLTYYGGQGHRPKWIACGMLIFAVAS 85  
EFX81434               1 MFLAVFCLACVLQGMFYTYFVSVLTTIEKLFQIQSKTTGIIMSATEMGQIGGALLLTYYGGQGHRPKWIGWGMVLFGASA 80  
EFN72542              99 AFLVTFCLTWVLQGMYYTYFVSVITTIEKLFQIQSKTTGIIMSATEIGQIGSSLLLTYYGGQGHRPKWIAWGMILFAVSS 178 
XP_003241873          65 VFLATFCFSWVLQGMFSTYFVSVITTLEKLFQLQSKTMGLVLSATEIGQIGSSLLLTYYGGQGHRPRWIASSMVLFGVAA 144 
Q9VVH9               175 VFMVVFLLAYILQGMYMTYFVSVITTIEKLFQIKSKTTGILLSASEMGQICTAMLLTYFAGRGHRPRWIACGMVLFSIAA 254  fruit fly
PDM64957              52 GFLTLFVIVYLMEAMGGMYIVSAIQNIEKQFRLPSKLSGILVSASDIGYIPTVIFIAYFGARGNRARWIGAGTLGMAVAY 131  Pristi...
XP_024085155          54 AFLVTFCITWVLQGMFYTYFVSVITTIEKLFQLQSKTTGFIMSATEMGQIGSSLLLTYYGGQGHRPKWIACGMVLFALSA 133  bed bug
7EEB_L               175 MLFAFPFFtYeiiipgrqsielcmeenek--------------------------------------------------- 203 
XP_011052736         131 FVLIIPHLtHrvrvieetqnvthmslyaddspe----------------------------------------------- 163 
WGS:AAQB:GK20834-PA  134 LLTSSLHFlYgagdealkltrefgaangsehimhlen------------------------------------------- 170 
EEC20306              86 ILCAMPHFlFidtslsvtslaraknaqnatvasq---------------------------------------------- 119 
EFX81434              81 ALCSLPHFlFwrtkpntgsssslssmlapdlyggglg------------------------------------------- 117 
EFN72542             179 FTCSLPHFiFgeqlilqnemllsgvgpggngrglnntdpipanlckfpernn---------------------------- 230 
XP_003241873         145 FACSSPHFlFghhqysssasmmgagnsttdyypsnmcvapdlnisd---------------------------------- 190 
Q9VVH9               255 FSCALPHFiFgeqlmhssvilqqtqvsppnnsfsshwlnasseqvnp--------------------------------- 301  fruit fly
PDM64957             132 LLIASPNFlFptpplargtfgyvkdslmpsnellapnaslalllhyplisdrftpaqignlskfpvaaeinhqmvinnks 211  Pristi...
XP_024085155         134 FACSLPHFmFgqqmltenssvlvppntcrldsylalns------------------------------------------ 171  bed bug
7EEB_L               204 ---------------------------------------------------------------------rniicgnsvpn 214 
XP_011052736         164 -----------------------------------------------------------------lctpvlsriileeep 178 
WGS:AAQB:GK20834-PA  171 -------------------------------------------------------------nraklcqqnassscvqesd 189 
EEC20306             120 ---------------------------------------------------------------waklchssdmplsqsri 136 
EFX81434             118 -------------------------------------------------------------llatmdpsssseqqaisrt 136 
EFN72542             231 ----------------------------------------------tldgwnistpasqtdsseyckgdflreqriqski 264 
XP_003241873         191 ----------------------------------------------------sgstrqpvqqhdmceqnelseqleqsrn 218 
Q9VVH9               302 --------------------------------------------------nlcilggnqthsgsecneerqleqashski 331  fruit fly
PDM64957             212 spymvdyglmheavfeahkllnstpdaadaskfrsllatyvarrkdgmraasnapfsycsalvnsmqakirelkcmnged 291  Pristi...
XP_024085155         172 -----------------------------------------------------------siyddqckeeylveqriqski 192  bed bug
7EEB_L               215 rskciyfHIGGQCIHGIAGMPIYILGITFIFDHIPTSSCGFYLAIGHSAYLIGYLLGMVGG---LQNFQPPpkektvEIE 291 
XP_011052736         179 cyitmviIILVLIVSGMSNITYYALGISYLDDNTKRKHVTGFIGIIIAVKITGIVLGYLLGwgcLRID-----------A 247 
WGS:AAQB:GK20834-PA  190 awipqavLLTAQVISGVGQALFYVLGISYMDDNLTKAKSAVMLSLSTFLRMLGPAIGFSLAafcLRLYIEP------SLE 263 
EEC20306             137 thvvlsvFFISLLLIGIGATAVYTLGIPYIDDNVANRESPLYFGITIGVRIFGPVFGFLLGsycTSVYVNF------PFE 210 
EFX81434             137 ttvvlafFFLSLLGIGMGRTAVETLGIPYMDDNVAGRESPTYFAINIGVKILGPVFGFVLGslcTSIYVDP------LVE 210 
EFN72542             265 ttvvlaiFFVSLLGVGMGQTAVYTLGIPYIDDNVASRESPLYFAITIGVRILGPALGFILGslcTMVYADL------TRT 338 
XP_003241873         219 tqivlviFFTSLLGVGIGQTAVYTLGIPFIDDNVASRESPLYFSITIGVRILGPSFGFLLGalcTSLYADL------SSE 292 
Q9VVH9               332 tvivlciFFGSLLSSGIGQTAVATLGIPYIDDNVGSKQSPMYMAVTIGMRILGPASGFIFGsfcTRWYVNF------S-N 404  fruit fly
PDM64957             292 shgpfivFCMALLLLGIGRTLPWSLGVPLIDDNVSKKSMPTYFGAISFIRILGPISGFLVAsvvNKFYFDFnp--peGLR 369  Pristi...
XP_024085155         193 ttlvlaiFFISLLGVGMGQTAVYTLGIPYIDDNVASRESPLYFAITIGVRILGPALGFILGslcTRLYVDL------SLD 266  bed bug
7EEB_L               292 P-------------AkvyqllqsgWWKTFLIIAAISFCVSFMMVCFPTSLPGAHKLRLAKRKEpp-------------tI 345 
XP_011052736         248 EdfsvvnsyrdqigA---------WWLGFPILSILLVIPGLLLSWFPRRLPSEVVEQAAASLLdraa--------irnrA 310 
WGS:AAQB:GK20834-PA  264 Plitpkd--prwlgA---------WWLGWLILAAAVLASAVFMFFFPKELPSAKARRML--------------------- 311 
EEC20306             211 Tsnlspg-dphwigA---------WWLGVFIVGAALIVTALPMMAFPRNLPQRRSLAQLRALRpgs-----------dqH 269 
EFX81434             211 Pdvtpkd--prwigA---------WWLGMIFVASTILLASLSMFAFPRRLPRKGRQAAHRPKQingkml----paqaktE 275 
EFN72542             339 Pqitptd--prwvgA---------WWLGLVLISAMLMFVSIGMFAFPTRLP-KSRT------------------------ 382 
XP_003241873         293 Pnmdtnn--prwvgA---------WWLGLVGISATLLLASVPMFAFPKRLPGPSSASNATLKKqnppqlavngcaepslS 361 
Q9VVH9               405 Pgfdatd--prwigA---------WWLGPVAIGSLMLLASIAMFSFPKQLRGKQKPPGQT-------------------- 453  fruit fly
PDM64957             370 Pedqs------wigA---------WWLGFIIIGVLTIVPSIALCLFPTANVNVTSADGKQRKInf------------ndK 422  Pristi...
XP_024085155         267 Pqitptd--prwvgA---------WWLGLVMISSLLILSSLAMFSFPKRLS-TCRPIA---------------------- 312  bed bug
7EEB_L               346 DRRLKDMK-----------IQPHLKGFLHNIWHILKNPLMLTQAICKVSEYLTFNTSLYFLPHHLQTQFLITPGIASLLT 414 
XP_011052736         311 PHRTTSQK-------------VGNPDFWPSLCRLFTNRILICNILATAFSAMALLNFMTLENIFLESRFLIPRPTGMLR- 376 
WGS:AAQB:GK20834-PA  312 -EKPETKHlq--------pKDLSVGDMMIAIRRILSNKVFILNTFSSIVYFFGYMVYWIFTPKYIEVQYRQSAAVATMAT 382 
EEC20306             270 RNGMVCLKhqqalqqklyiAPSSLSDFPSAIRRLLKNEILLYRTASSVLHILPIAGLYTFLPKYLESQFRLTETKANMIT 349 
EFX81434             276 QTVASAMRn----------KNPSLKDFPKAIRRLLKNDILLFRTASSVLHILPVAGLYTFLPKYLESQFRMAAHTANMIS 345 
EFN72542             383 ---PPRRAd---------aKKPSLRDFPSAVKRLLKNDILMFRTASSVLHILPIAGLYTFLPKYLESQFRLPAHHANMIS 450 
XP_003241873         362 SPPPPPYDgls-----avpKAPRLKDFPTAVKRLLKNDMLMYRTASSVFHLLPLAGIYTFLPKYFESQFHFPTHTANMVT 436 
Q9VVH9               454 ATPAAPVEp---------eEKPKLKDFPKTVRRQLSNDILMFRTASCVFHLLPIAGLYTFLPKYLETQFRLATYDANMIA 524  fruit fly
PDM64957             423 HRDMENSEk---------gLSERIKDFGSTYRSVITSKIYVYSATGRILDIMAFKGYIVFLPKYLENHFGIARYLVHRYM 493  Pristi...
XP_024085155         313 --PSKKHPrdk------prKNPSLRDFPKAVKRLLKNDILMFRTASSVLHILPIAGLYTFLPKYLESQFRLTAHDANMFS 384  bed bug
7EEB_L               415 G---------AF-VLpGGIIGH--FLGGLIVDRLEMTNKNKLKFTLVTTVVSVGLFLLIFFvECQTTTFA-GineDYDGY 481 
XP_011052736         377 GfddplpsrlVTnIGrPILIGLviIISGLVLAKAKPRARFIIGYSFIIVFLIIAIIIGLIFaTCDKSSVV-Nlekss--- 452 
WGS:AAQB:GK20834-PA  383 G---------TI-ALgFSAAGV--LLSGYVLSRYKPSARLLAAWNATVDFLTVAGMVGYVFiACEGSDNVtNmtis---- 446 
EEC20306             350 G---------FA-GIlVMGVGI--FASGTFMRKYKPNARFVAKWIAFCALAYSIGMVILMWvGCPLGEYV-Gl--NS--- 411 
EFX81434             346 G---------IG-GIgVMGIGI--FFSGVFIRLKKPSPKFVAAWIALTALLYAIGMALLMLlGCPMSDFS-Gl--EQ--- 407 
EFN72542             451 G---------VG-GIlVMGLGI--IISGVFILRAKPNARFVAAWIAFTAVVYAIGMGVLMFiGCPMDDFA-Gl--VS--- 512 
XP_003241873         437 G---------IY-GImVMGIGI--IISGIFILKKNPNARAVAAWIAFTALAYAIGMCILMFfGCPTTNIT-Gl--RY--- 498 
Q9VVH9               525 A---------FC-GIlVMGIGI--VISGLFILKRKPTARGVAAWIAFTALVYSAGMIILMFiGCSMNDFA-Gy--KP--- 586  fruit fly
PDM64957             494 A---------IF-GVfGFALGS--GCGGLLTRKFKLNGKRVALYVFIVSSLNILMYFSKIFiACDSSLAE-IgrqHEGAT 560  Pristi...
XP_024085155         385 G---------VG-GIlVMGLGI--ILSGVFILRVKPNARFVAAWIAFTAVIYAIGMGILMFmGCPMTDFV-Gl---K--- 445  bed bug
7EEB_L               482 Gql---gnLTADCNEY--CDCTTSLYTSICGRde---------------keYFSPCFAGCKATKVSQTEKTYYNCSCIKE 541 
XP_011052736         453 ------dtllRYCNKD--CRCSKDADFRPICDss---------------geFTYYNPCYAGCSTIIYVDDVKIYSGCNCV 509 
WGS:AAQB:GK20834-PA  447 ------rqanDTCSPS--CHCDYVAYAPICGPqnvt------------yisPCHAGCMDTGKDDLGQTIFTNCQCMGNSS 506 
EEC20306             412 Ehkg-ldfLPPACNSS--CDCKSGLFSPV-------------------------CHNSVTYLS-PCLAGCSQPTFNSCHC 462 
EFX81434             408 Tdsg--mtVKLPCNRT--CECDTSVFAPICTStg---------------etYFSACHAGCANLTQFGSQIGNTTYSNCEC 468 
EFN72542             513 Hsdg-lssFEPICEAS--CDCDRNKFSPICGAdgrtyfsachagcsnytvaDGKVASVSAKPSRNNTPQDMFYNCQCIEH 589 
XP_003241873         499 Deln-qpkFESSCSDQ--CVCDEELFSPICGVdgi-------------tyfSACHAGCRNRTSRKEYISGYKFTDCQCMN 562 
Q9VVH9               587 SdgnspalIEPTCSAAlnCTCDKENFAPICADg-----------------kMYISACHAGCSSSSLRPSDNRTLYSDCAC 649  fruit fly
PDM64957             561 Yn------LTHSCNVD--CGCEGAKLYPVCDRs-----------------gKPFFSPCHAGCREASHHGEHTSIEFSSCA 615  Pristi...
XP_024085155         446 Rets-lsrFEPVCDSG--CKCDYNKFNPICGKdgk--------------tyFSACHAGCQNVTIIDGKEVEFSDCLCMDN 508  bed bug
7EEB_L               542 GLaaSdd---eGqFIDAIAGTCD-SDC-LkLPLFFAFYFSATVFSNMCSIPVISIILQSVPANFTSLSLGVTYAIVKFVA 616 
XP_011052736         510 EE--Mt----eWgNDQAKDGPCDsSKCqVgWMVFEFGSLLAYTLIASTFVGDILVNIRSVYKQDKAISIGFWMMWVAVFV 583 
WGS:AAQB:GK20834-PA  507 IF--LgnsslsSeLPFGVDGPCP-VDCfGqFITFLVVMCILKLFGASSKNTGILISLRSVLPEDKSFALGLGSMVASIFA 583 
EEC20306             463 TG--Tn-----Dt---ISNGFCS-LECnNl-VWYIIVFSFFVLIHSTSEVGSMLLTLRCVESHDKALALGLIQFAIGLFG 530 
EFX81434             469 LD--Ag-----Vt---ATSGYCH-LECnNy-IWYIGIFSLFVLIHSTSEVGSMLLTLRCVHAKDKAMALGLIQFAIGLFA 536 
EFN72542             590 NV--Tipe-afSt---ATIGYCE-LECsNf-WVYMILFSVFVFIHSTSEVGSMLLILRCVDPRDKAMALGLIQFAIGLFG 661 
XP_003241873         563 TN--Ate--afP-------GPCK-DDCeDsGFWYIALFSLFVFIHSTSEVGSMLLILRCVHPQDKAMALGLIQFAIGLFG 630 
Q9VVH9               650 IP--Da-----Pe---AVNGYCD-NNCkNf-IYFILIFAICVFMHSTSEVGSMLLVMRCTHPKDKAMAMGVIQSAIGLFG 717  fruit fly
PDM64957             616 CA--A------D--GRVAKEWCV-QSCkPaTVAFFSTVLIGSFIGGLGIVPGLLILIRSVPPATRSAALGLQGFMISLFG 684  Pristi...
XP_024085155         509 YD--Pgg--qpNk---ASVGYCN-LECgNf-IWYILLFSLFAFVHSTSEVGSMLLILRCVDPTDKAMALGLIQFAIGLFG 579  bed bug
7EEB_L               617 SVPAPLLFRLSSAIACIYWdNNRC-GGK-ERCWIYNKNIL 654 
XP_011052736         584 YIPGKIVYEFVSNQMCQYW------GSQkTICHLHNSEKL 617 
WGS:AAQB:GK20834-PA  584 FIPSPIFFGWLIDNYCLVW-GKTC-SSK-GNCWLYDTKSM 620 
EEC20306             531 NVPCPIIYGAVVDSACLFW-EDNC-GEP-GACRVYDPSKF 567 
EFX81434             537 NVPCPIIYGAVVDSACFVW-EKTC-GEQ-GACWLYDAKTF 573 
EFN72542             662 NVPCPIVYGAVVDSACLVW-EYAC-GER-GACWLYDSNVF 698 
XP_003241873         631 NVPCPILYGAVVDSACLIW-EMTC-GKQ-GACSLYNSDSF 667 
Q9VVH9               718 NVPCPIIYGAVVDSACLIW-KSVC-GKH-GACSLYDADTF 754  fruit fly
PDM64957             685 TLPSPIIWGAIVDSTCLIW-DHACdGAR-GSCSLYDPAAL 722  Pristionchus pacificus
XP_024085155         580 NVPCPIVYGAVVDSACLIW-ETTC-GKQ-GACKLYDENFF 616  bed bug
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