Conserved Protein Domain Family
HSR

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pfam03172: HSR 
HSR domain
The Sp100 protein is a constituent of nuclear domains, also known as nuclear dots (NDs). An ND-targeting region that coincides with a homodimerization domain was mapped in Sp100. Sequences similar to the Sp100 homodimerization/ND-targeting region occur in several other proteins and constitute a novel protein motif, termed HSR domain (for homogeneously-staining region). The HSR domain has also been named ASS (AIRE, Sp-100 and Sp140). This domain is usually found at the amino terminus of proteins that contain a SAND domain pfam01342.
Statistics
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PSSM-Id: 427178
Aligned: 52 rows
Threshold Bit Score: 110.321
Threshold Setting Gi: 409168294
Created: 26-Apr-2021
Updated: 29-Sep-2021
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_015216561   8 EDADLRSQLRMLRTEIAMAIDDPFPLLYGLADHDIITEQLFKDTLDKK--KHEGIHKAVYSLLSRLLEKETLTIqnfWSN 85  spotted gar
EHB00132      11 LMVTLFQYFKAHKVEISYAIKKTFPFLEGLRDRELITNKMYKAYQDSCreSLVPVHRVMYNVLNDLEKIFDMAV---LEA 87  naked mole-rat
BAC37804      21 LIECMLKHFKTQKVAISNAIRSTFPFLESLRDHEFITGKMYEDLLDSCr-SLVPVDKVIYRALEELEKKFDMTV---LCE 96  house mouse
XP_008756287  49 PFELIFQHFKRQKVAISNAIKNPFPFLEGLRDHELITAKMYEDLQDSYr-ALVPVDKVIYRALDELEKTFSMKV---LCE 124 Norway rat
XP_007667882   5 LEKQLLIKFREKKLAISDAVNKLFPFIYSLRDQALISNRMLQHYKNES----VPMKERIYNVLEKLEKNFNKKV---LKV 77  platypus
XP_013124273  25 RDTNLRSLLRELRTDIAMAVDDPFPLVYGLADKNIITEQLLKETLEKE--AREGIHKAMYSLLSWVLEQSRSTVqafLNN 102 Nile tilapia
CAG07656       5 GETNLRSLLKHLRTDIAMAVDDSFPLVYGLADKNIITDQLQKDTLEKE--SREGIHKAMYSLLSWVLQQRRSVIrafWSN 82  spotted green p...
XP_009296781   8 EESDLRSQLRACRTEIAMAIHDPFPLLYGLADHNVISEQILRETLERK--KKDGIHKAIYSLLTLLLDQDTTVLkafWKN 85  zebrafish
NP_001258486   4 GDGMLRRLLRLHRTEIAVAIDSAFPLLHALADHDVVPEDKFQETLRLK--EKEGCPQAFHALLSWLLTRDSGAIldfWRI 81  house mouse
XP_014348180   8 CDADFRQILKMNRTEISMAVDDTFPFLHGLLDHDVVTEEMFKETLNMK--EREGSHKAVYFLLTWLLKRDQSILqdfWKI 85  coelacanth
EHB00132      11 LMVTLFQYFKAHKVEISYAIKKTFPFLEGLRDRELITNKMYKAYQDSCreSLVPVHRVMYNVLNDLEKIFDMAV---LEA 87  naked mole-rat
BAC37804      21 LIECMLKHFKTQKVAISNAIRSTFPFLESLRDHEFITGKMYEDLLDSCr-SLVPVDKVIYRALEELEKKFDMTV---LCE 96  house mouse
XP_008756287  49 PFELIFQHFKRQKVAISNAIKNPFPFLEGLRDHELITAKMYEDLQDSYr-ALVPVDKVIYRALDELEKTFSMKV---LCE 124 Norway rat
XP_007667882   5 LEKQLLIKFREKKLAISDAVNKLFPFIYSLRDQALISNRMLQHYKNES----VPMKERIYNVLEKLEKNFNKKV---LKV 77  platypus
XP_013124273  25 RDTNLRSLLRELRTDIAMAVDDPFPLVYGLADKNIITEQLLKETLEKE--AREGIHKAMYSLLSWVLEQSRSTVqafLNN 102 Nile tilapia
CAG07656       5 GETNLRSLLKHLRTDIAMAVDDSFPLVYGLADKNIITDQLQKDTLEKE--SREGIHKAMYSLLSWVLQQRRSVIrafWSN 82  spotted green p...
XP_009296781   8 EESDLRSQLRACRTEIAMAIHDPFPLLYGLADHNVISEQILRETLERK--KKDGIHKAIYSLLTLLLDQDTTVLkafWKN 85  zebrafish
NP_001258486   4 GDGMLRRLLRLHRTEIAVAIDSAFPLLHALADHDVVPEDKFQETLRLK--EKEGCPQAFHALLSWLLTRDSGAIldfWRI 81  house mouse
XP_014348180   8 CDADFRQILKMNRTEISMAVDDTFPFLHGLLDHDVVTEEMFKETLNMK--EREGSHKAVYFLLTWLLKRDQSILqdfWKI 85  coelacanth
XP_015216561  86 LFKDYNLERYPKLQSVFTSFPKD 108 spotted gar
EHB00132      88 LFSEVNREVYPALMNIYKDFQNV 110 naked mole-rat
BAC37804      97 LFNEVNMEKYPDLNLIRRSFGCV 119 house mouse
XP_008756287 125 VFSNVNMEKYPDLQLIHQSFEHV 147 Norway rat
XP_007667882  78 LFSRNNVKEYPDLKRIRRTFEDV 100 platypus
XP_013124273 103 LSKDYNLDSYPRLQTLLTNLDCR 125 Nile tilapia
CAG07656      83 LFKDYNLDSYPKLQKLITNLPSG 105 spotted green pufferfish
XP_009296781  86 LCKEYNKECYPKLETVFMNLPKG 108 zebrafish
NP_001258486  82 LFKDYNLERYSRLHSILDGFPKD 104 house mouse
XP_014348180  86 SFKEYNLERYPKLKPVYNSFPKD 108 coelacanth
EHB00132      88 LFSEVNREVYPALMNIYKDFQNV 110 naked mole-rat
BAC37804      97 LFNEVNMEKYPDLNLIRRSFGCV 119 house mouse
XP_008756287 125 VFSNVNMEKYPDLQLIHQSFEHV 147 Norway rat
XP_007667882  78 LFSRNNVKEYPDLKRIRRTFEDV 100 platypus
XP_013124273 103 LSKDYNLDSYPRLQTLLTNLDCR 125 Nile tilapia
CAG07656      83 LFKDYNLDSYPKLQKLITNLPSG 105 spotted green pufferfish
XP_009296781  86 LCKEYNKECYPKLETVFMNLPKG 108 zebrafish
NP_001258486  82 LFKDYNLERYSRLHSILDGFPKD 104 house mouse
XP_014348180  86 SFKEYNLERYPKLKPVYNSFPKD 108 coelacanth
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