6SP2


Conserved Protein Domain Family
Serinc

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pfam03348: Serinc 
Serine incorporator (Serinc)
This is a family of eukaryotic membrane proteins which incorporate serine into membranes and facilitate the synthesis of the serine-derived lipids phosphatidylserine and sphingolipid. Members of this family contain 11 transmembrane domains and form intracellular complexes with key enzymes involved in serine and sphingolipid biosynthesis.
Statistics
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PSSM-Id: 397431
View PSSM: pfam03348
Aligned: 162 rows
Threshold Bit Score: 266.742
Threshold Setting Gi: 219120096
Created: 20-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
6SP2_A        16 CcGGTAASMCCSACp---SCTNASSSRFMYAFILLVGTVLGAI----------AL---SPG--LQDTLKKm--------- 68 
XP_010322266   7 CcASLTCGLCTSVAs----gVTRSSARLAYCGLFGVSLIVSWV----------IRevaSPL------LKNfswin----- 61  tomato
XP_009129653   7 CcASATCGLCSSVAs----gISRKSARIAYCGLFGASLVVSWI----------LRetaAPL------LEKlswin----- 61  field mustard
Q236K4        13 CcCQAFCNDICRSLkrvfTLSIRQQMRLAYISLFFVFTLLTLF----------SMyqiPGWlgVWSKFIH---------- 72  Tetrahymena the...
XP_001032827  11 CaGKAFCSNACGCCkslcKTTWKQQIRLAYIILNIVFTLFIIF----------TFyylQDIfqTFSKYIN---------- 70  Tetrahymena the...
A0C5A5        12 CtGMACCKSLCCCCkiccGSTFKEQIKLAYILLNYTTIFVTMI----------FCfflQGLfdNYLSFIS---------- 71  Paramecium tetr...
A0CSR0        12 CaGTQICNLACCCCkyfaETTLKEQIKLAYILLNYLIMAFTVI----------ALyyiQDFyiNYLHYFG---------- 71  Paramecium tetr...
EGR28880      12 CaGKEFCSVICTFFkcccKMTMSQQIRLSYVILNSLLFAFTII----------VLhyiRDLfsYFARYLH---------- 71  Ichthyophthiriu...
Q22U62         8 CaGREVCSACCACFkcccKMTMKQQIRLSYVLMNILFFLFAII----------VLhyvQSLfdYFSSYIH---------- 67  Tetrahymena the...
XP_002180794  19 SaTNSLCNACLGST------SENSTGRKRSVLLLTLAVAIALWfqydvgpaivTK---SGW--VWKAFQWipgfgkmlyh 87  Phaeodactylum t...
6SP2_A        69 pF---CinstssyssgalsavsGg-----sLQVDCEyalGYMAVYRVCFGMACFF--ALMSLIMLGVKSSRDPRSHIQNN 138
XP_010322266  62 --------------------------tsdnlSKEWF---QAQAVLRVSLGNFLFF--GVLALIMIGIKDQNDRRDCLHHG 110 tomato
XP_009129653  62 --------------------------tsdsyTKEWY---QQQAVLRVSFGNFLFF--AIYALVMIGVKDQNDRRDSWHHG 110 field mustard
Q236K4        73 -----C----------------PsesshpkDNMACL---GISALYRMSFSLVILF--SILVLFCLLRNEASKF---VNEN 123 Tetrahymena the...
XP_001032827  71 -----C----------------Pse---agGGSECL---GASSVYRMSFSLASFYlgLFLLLFICCGIEAKKM---INDG 120 Tetrahymena the...
A0C5A5        72 -----C----------------Ps-----dDSSSCL---GVSSIYRICFVLMWMY--IFLMILMLIRGEIAKV---ANEG 117 Paramecium tetr...
A0CSR0        72 -----C----------------Pe-----gISNLCL---GISGIYRMSFVLTIFY--IIILLFMCQKGWLAKM---INDG 117 Paramecium tetr...
EGR28880      72 -----C----------------Pea---sgGQSQCL---GSSSVYRMSFALAILY--LAVLIAVYARNQCSKL---FNEG 119 Ichthyophthiriu...
Q22U62        68 -----C----------------Peq---agGKLNCL---GVSSVYRISFSLAILY--AIILLAVWARNECSKL---INEG 115 Tetrahymena the...
XP_002180794  88 aWydsC----------------EvykdndaLLQQCA---GNAGVYRPTFVASLFF--AVLAIVTKVEPY-------LNKE 139 Phaeodactylum t...
6SP2_A       139 FWPLKFLICFGAAIGAIFIPDGS---FGpAM-MWVGLIGGLAFILVQLVIIVDFAHSLAENWIESAE------------- 201
XP_010322266 111 GWVAKLVIWVLLVALMFFLPNG----VItIY-GFLSKFGAGFFLLIQVIILLDATHSWNDSWVAKDE------------- 172 tomato
XP_009129653 111 GWPVKMIVWFLLVVLMFFVPNE----IIsIY-GILSKFGAGAFLLVQVVLLLDATHNWNDSWVEKDE------------- 172 field mustard
Q236K4       124 FWFQKIIGLIALFILQMWIPNDTyiiY-----GSVSKLFGVIFALFQSIMCIDLFYSWSEVWVKQYEqgvg--------- 189 Tetrahymena the...
XP_001032827 121 LWCFKITYIILVFILVFFIPNSFfegY-----SQFAKYVSILYMLFQSLVIIDLLYKWSQTWVKYYDqgnqs-------- 187 Tetrahymena the...
A0C5A5       118 LWPLKFLYIAVFFFGTLFIKNSFfkgY-----VYFAIVISGFFMIFQIIMLIDVFYLWGQSWIRIYDnggey-------- 184 Paramecium tetr...
A0CSR0       118 LWLLKFIFITVFFYGTLYMPNRFfevF-----VDISIVASGIYQLFQIIIYIDIFYLWAEKWARMYDdgieg-------- 184 Paramecium tetr...
EGR28880     120 LWCIKISAVLGMYISFMFVSDSFfngY-----RVFAQVFGGFYLLFQTIILIDIFYLWGQNWKAKYDeveaqnaennssf 194 Ichthyophthiriu...
Q22U62       116 LWLLKIFFIVGIFIGFMYVDYSFfdgY-----RDFARIFGAIFLVIQSVMLIDIFYMWGQKWKAYYDegaqw-------- 182 Tetrahymena the...
XP_002180794 140 VWPAKYVVFLFAVTISMFVSSAP---MFtGFyLWLARFGATLFVLLQQIILIDVAYNWNEDWVDRADqad---------- 206 Phaeodactylum t...
6SP2_A       202 ----NS---RGYYYALAGVTLLCYILSLTGITLLYIYFtTSTG--CGINKFFISINLIFCLAISVISILPAVqeRLPHSG 272
XP_010322266 173 ---------QKWYVALLVVSVACYIATFVFSGILFMWF-NPSGhdCGLNVFFIVMTMILAFAFAVIALHPKV-----NGS 237 tomato
XP_009129653 173 ---------RKWYVALLVISIVCYIATYAFSGVLFMWF-NPSGhdCGLNVFFIVMTMILAFVFAIVALHPAV-----NGS 237 field mustard
Q236K4       190 ----------iyeyLLYIFSFGCYASTFYLIYNNYQLY---PC--SGTQ---NLINILIVVAISILNLSP----INAKPS 247 Tetrahymena the...
XP_001032827 188 -----------mkyvLVFTSLILYGLTIALNVLTFIWF---KG--CSTNTAISSVNIVILVVITFIQILG----FNPHGS 247 Tetrahymena the...
A0C5A5       185 -----------mkyiLIITTAILYGGAFTLNIFNFIWF---SG--CGTNIFMNVFTILLIVGATGVQLLG----WNPQGS 244 Paramecium tetr...
A0CSR0       185 -----------mgsaLVAAASLTFTLALILNIYNFIWF--------DHNYIINLINIAIIILLTVVQLFG----FNPNGS 241 Paramecium tetr...
EGR28880     195 nlygIL---------LIGITLSLYTASILLNAYNFIWF---KG--CQFNIIVNALNLLLVISITFVQFLG----FNPSGS 256 Ichthyophthiriu...
Q22U62       183 -----------mapvLIGTAVVLYGLTITLVVLNFIWF---NG--CGLNTFINVANLILVIAITVVQLLG----YNPHGS 242 Tetrahymena the...
XP_002180794 207 --rmDYgsgANWLHAIVATCVAFYVAACAGIWILYQNF---TG--CPENTWIITLTMLGVLGLTAIQLSGQ------EGS 273 Phaeodactylum t...
6SP2_A       273 LLQSSLVTLYTVYLTWSAVANNP-EKeCNPGMFGMmegfgnatttaapsthttrvtfdttnIIGLVVWLLCILYN----- 346
XP_010322266 238 LLPASVISVYCAYVCYSGLSSEPrDYvCNGLHNKSkavt------------------tstlVLGMLTTVLSVLYS----- 294 tomato
XP_009129653 238 LLPASVISVYCAYVCYTGLSSEPhDYvCNGL-NRSkavt------------------astlTLGMLTTVLSVLYS----- 293 field mustard
Q236K4       248 ILTCGAVCLFITYLNWSAMTNIQq-TeCNYYANKQeafi------------------qiegFIGVFLIILSLGYI----- 303 Tetrahymena the...
XP_001032827 248 LIASGGIGLYISFLTFSSQFSSPd-SeCNSLISNSdnkng----------------fyfdlSIAIILNFIVLMYV----- 305 Tetrahymena the...
A0C5A5       245 LLTSGAMAIYIVFQAYQAQSSWPd-TeCNSLSKSEgtri-------------------veiVVGILLTVVSLLYL----- 299 Paramecium tetr...
A0CSR0       242 LLATGCISCYITYQTFSALSSYPn-AdINIFYDSEknmk-------------------vqmFVNGILNFVALIYI----- 296 Paramecium tetr...
EGR28880     257 LLTSSAMSFYITFLAFSGQLSSEs-G-CNSAISSNaifa-------------------ielSVGVAFLLVTLLYL----- 310 Ichthyophthiriu...
Q22U62       243 LICSGAQGLYMTFLTFSAQLSGEs-S-CNLAIDNNsift-------------------lelVVGLIILIVVQLYL----- 296 Tetrahymena the...
XP_002180794 274 LLTSSVMSLYSVYLAYSMVSKNPn-AsCNPQLgsnd---------------------vwsiVIGLTLTAVSLAWTgwswt 331 Phaeodactylum t...
6SP2_A       347 --------CISSAVEv--------------------------sK---------IshdnsEKRVLTEal----------sd 373
XP_010322266 295 --------ALRAGSAttfmspp---------------------------------------------------------- 308 tomato
XP_009129653 294 --------ALRAGSSttflsp----------------------------------------------------------- 306 field mustard
Q236K4       304 --------TFGTADEssrysqipsgdnlmaslrkseleekdsdDddflieagySdvvdlEQDAIDLtki--------ekr 367 Tetrahymena the...
XP_001032827 306 --------TFSSKESt-------------------------------------------SKTTQNIinnapqalladnkd 334 Tetrahymena the...
A0C5A5       300 --------TFGTSNS----------------------------------------------SATNIvqleskdeklenqq 325 Paramecium tetr...
A0CSR0       297 --------IFATQEQskqala-----------------------------------------------------ildksn 315 Paramecium tetr...
EGR28880     311 --------SFVKKNInn-------------------------------------------------------------iq 321 Ichthyophthiriu...
Q22U62       297 --------TFGTKESs------------------------------------------qKRIPVSQnvelngailadkdq 326 Tetrahymena the...
XP_002180794 332 aeerlnvdGVQSAKSvtga---------------------hpiGgngqinldvPfldaeDQPRQGLvtdsd--------- 381 Phaeodactylum t...
6SP2_A       374 TEAGTDg-------------------sGK---PSTDT------E--------TEGVTYS----WS--MFHLVFVCASLYV 411
XP_010322266 309 ---------------------ssprsvVGekkSLLASeelesg----kgspeARPVSYS----YT--FFHLIFALASMYS 357 tomato
XP_009129653 307 ----------------------pssprAGgkeALLedp--edgKkng--eaeARPVSYS----YS--FFHIIFALASMYA 354 field mustard
Q236K4       368 NSQKKDdsnks------------aestAQavrKELKRlremrqL--------RRMKDYKtn-tYI--YFHAIMILSSFYI 424 Tetrahymena the...
XP_001032827 335 DEEDKSldqnkvsnqnayennsmqqpqGQqqqQSQNLnqqqanLsdedkndiRRLVVIQq---FK--AFYVVMFFVSIYT 409 Tetrahymena the...
A0C5A5       326 REANQAegnqd------------eeqqLLqqqQKLEEakalvkQ--------AEMLPYTtn-qYL--IFHTIMFITIIYM 382 Paramecium tetr...
A0CSR0       316 EKKRSNqnsnq------------qieiEMtstQQMNEakalieQ--------IELQPYStn-qYI--VFHIVMTFCSMYM 372 Paramecium tetr...
EGR28880     322 NQQNKKedlek------------eqasLVqnqQQLNQq-----Q--------DELEIYKntnnYI--IFHMVMFVSSIYC 374 Ichthyophthiriu...
Q22U62       327 EEESEEndiddeengshhqinkqnkepIQqnsQEQKQlspeeiEfekyqkcdKKLRPYIysntYI--IFHIVMLTSSVYG 404 Tetrahymena the...
XP_002180794 382 ------------------------------------------------gpaaRSGRVAN----AHvwKLNVVMLLISCFV 409 Phaeodactylum t...
6SP2_A       412 MMTLTNW--YKPHseIEL---FNGNEASMWVKIVSSWLGVFIYGWSLAAPIVLTNRD 463
XP_010322266 358 AMLLSGWt-SSSEssEL----IDVGWTSLWVRICTEWVTAGLYVWSLVAPLLLPDRE 409 tomato
XP_009129653 355 AMLLSGWt-DSSEsaSL----IDVGWTSVWVKICTGWATAALYIWTLIAPLILPDRE 406 field mustard
Q236K4       425 VMLLTNYgaIQIDekIDwt-tYKTSNSSMNIKFGISYFTTFIYIWTIVAPLIFPDRQ 480 Tetrahymena thermophila SB210
XP_001032827 410 CMLITNWgsPDFSnnTfq--lYQESSASYWIKIIIAWLTAAIYIWTLIAPKIFPNRD 464 Tetrahymena thermophila SB210
A0C5A5       383 MILLTNWt-------------YQPNKLAYWVKMITSWLAALLYIWTLIAPHIFPDRD 426 Paramecium tetraurelia
A0CSR0       373 AMMITNWgsPSIRvgTfe--lYMPSQLSYNVKIGSSWICSGLYFWTLIAPRVLPDRf 427 Paramecium tetraurelia
EGR28880     375 AMLITNWggSSLNnf----tiYQPSQTSYWIKIICSWISSILYIWTLIAPRVFPNRD 427 Ichthyophthirius multifiliis
Q22U62       405 SMLLTNWgsPDMNasTfn--mYKPSESSYWVKIVVSWASSLLYIWTLVAPSIFPDRD 459 Tetrahymena thermophila SB210
XP_002180794 410 AMTLTGWgtIEELdeNANaanPTVGRVNMAMLGISQWLAIGLYVWTLLAPRLYPDYE 466 Phaeodactylum tricornutum CCAP 1055/1
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