Conserved Protein Domain Family
HNF-1B_C

?
pfam04812: HNF-1B_C 
Hepatocyte nuclear factor 1 (HNF-1), beta isoform C terminus
This family consists of a region found within the alpha isoform and at the C terminus of the beta isoform of the homeobox-containing transcription factor of HNF-1. Different isoforms of HNF-1 are generated by the differential use of polyadenylation sites and by alternative splicing. The C-terminal region of HNF-1 is responsible for the activation of transcription. Mutations and polymorphisms in HNF-1 cause the type 3 form of maturity-onset diabetes of the young (MODY3).
Statistics
?
PSSM-Id: 461438
Aligned: 9 rows
Threshold Bit Score: 294.983
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
?
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
Q90867       285 AMDNFSGPQPTSAP-PLTPHNSSSLqPPPALSPTKVH-GVRYNQQPASEAESSSS-NHHGNSS---MVTTQTILHQVSPP 358 chicken
P23899       314 AMDAYSSNQTHNLN-PLLTHGSPHH-QPSSSPPNKLS-GVRYSQPGNNEVTSSSTiSHHGNSA---MVTSQSVLQQVSPA 387 Norway rat
XP_014345048 286 AMDSYSNQQPNTVT-PVTPHNTSl--QHGALSPNKVQvGVRYGQQSTSDDMSPSV-SHHGNSA---MVTTQTILQQVSSP 358
XP_006151581 282 AMDTYSGPPPGPGPgPTLPAHSSPGlPPPALSPSKVH-GVRYGQPANSEAADVPS-SSGG--P---LVTVSAPLHQVSPT 354
XP_006640975 193 AMDAYSGAPSHGMN-SLLSHSSPHQpPASTSPPSKMQ-GVRYSQQGASEVTSSTTiSHHGNNV---MATSQSVLQQVSPG 267
XP_007248687 322 AMDAYSG-QTHSMN-SLLSHSSPHHpQASTSPPSKMQ-AVRYNQ-GPGEVSSSTTiSHHSGNG---MTSGQSVLQQISPG 394
XP_022615518 327 AMDAITA-PTHSIN-PLLSHSSPHHpQTSASPPm-------RYSQGPGEVTSSTTiSHHNSNA---MATSQSVLQQVSPG 394 greater amberjack
CAG02502     279 ALDAPFS-QPSSAN-HALPTSPEP--------------GVKYSPQMLCDGVTSARlAGGDRTG----------CLVVSPV 332 spotted green p...
XP_016853691 339 AMDAYSTGQPHTMN-LLLSHNSPHHvQASASPPSKMT-GVRYGQAGPNDVPSSSSiGHHVNSTsamVTSSQAILQQVSPV 416 green anole
Q90867       359 GLEP--SQNLLSTDTKLISAPGGTLPPVSTLTALHSLeqnPHALGQQTQNLIMASLPGVMAIgagetsslaprftntggS 436 chicken
P23899       388 SLDP--GHSLLSPDSKMISVSGGGLPPVSTLTNIHSL---SHHNPQQSQNLIMTPLSGVMAI-----------------A 445 Norway rat
XP_014345048 359 GLEP--SQSLLTTDTKLISTSGGTLPPVSTLTALHSLhqnPHTVTQQTQNLIMASLPSVMAIgpgdtptltpslsntgpS 436
XP_006151581 355 GLEP--SHSLLSTEAKLVSTAGGPLPPVSTLTALHSLeqtSPGLNQQPQNLIMASLPGVMTIgpgepaslgptftntgaS 432
XP_006640975 268 GLDP--SHSLLSPDAKMISVSGGGLPPVSTLTNIHSLsqsSHHGHQQTQNLIMTPLSGVMAI-----------------T 328
XP_007248687 395 ALDP--SHSLLSPDAKMISGSGGGLPPVSTLTSMHg----PHHAHQQTQNLIM-PISGVMAI-----------------A 450
XP_022615518 395 GLDH--SHSLLSPDAKMISGSGGGLPPVSTLTNIHS----SHHSHQQtqNLIM-PLSGVMAI-----------------A 450 greater amberjack
CAG02502     333 QLEP--SHTLLDTQNPKQVSSGGPLPPVSTLTSLHSL----SASPASSPSLIMASLPSVMSLgesslliaevnkgrhsgS 406 spotted green p...
XP_016853691 417 GLDPghGHGLLAPDGKMITVSGGGLPPVSTLTNIHSF---SHHNPSQSQNLIMAPLSGVMAI-----------------T 476 green anole
Q90867       437 TlviGLTSTQPQSVPVINSMGSSLTTLQPVQFSQQLHPSYQQPLMQQVQ-SHINQSPFMATMAQIQNPHaLYGPKSEVAQ 515 chicken
P23899       446 Q---SLNTSQAQGVPVINSVASSLAALQPVQFSQQLHSPHQQPLMQQSPgSHMAQQPFMAAVTQLQNSH-MYAHKQEPPQ 521 Norway rat
XP_014345048 437 TfviGLTTSQAPNVPVINNMGSSFATLQPVQFPQQLHSPHQQPIMQQVQ-GHMAPNSFMATMAQLQNPH-VYSHKPELPP 514
XP_006151581 433 TlviGLASTQAQSVPVINSMGSSLTTLQPVQFSQPLHPSYQQPLMPPVQ-SHVAQSPFMATMAQLQSPHaLYSHKPEVAQ 511
XP_006640975 329 Q---SLNTSQAQSVPVINSVTGGLAALQPVQFPQQLHSPHQQSLMQQSP-SHMAQQPFMATVTQLQNSH-MYSHKQEPPQ 403
XP_007248687 451 Q---SLNTSQAQTVPVINSVAGSLATLQPVQFSQQLHSSHQQGLMQQSH-SHMSQQPFMATVT---HSH-MYSHKQEPPQ 522
XP_022615518 451 Q---SLNTSQSQTVPVINSVAGSLAALQPVQFSQQLHSPHQQSLMQQSP-SHMSQQPFMATVT---HSH-MYPHKQEPPQ 522 greater amberjack
CAG02502     407 GvvtGLASTQPQSVPVINNVGAGFTTLQPISFQQQLHASPQQPIPQHLQ-GHMGSSPFMATMAPLPCH--MY--KSDSPQ 481 spotted green p...
XP_016853691 477 Q---SLNSSQAQTVPVINTVASSLAALQPVQFSQQLHSPHQQSLMQQSP-SPMAQPPFMATVTQLQNSH-MYSHKQEPPQ 551 green anole
Q90867       516 YTHTGLLPQTMVITDTANLSALTNLTPTK 544 chicken
P23899       522 YSHTSRFPSAMVVTDTSSINTLTSMSSSK 550 Norway rat
XP_014345048 515 YTPSGLFSSTMVITDTGNLSAITGLAPTK 543
XP_006151581 512 YTHTGLLPQTMLITDTTNLSALASLTPTK 540
XP_006640975 404 YSHPSRYPSAMVVTDASSISTLASMPSSK 432
XP_007248687 523 YSHPSRFPSAMVVTDTNSLSTLSSMSSNK 551
XP_022615518 523 YSHPSRFPSAMVVTDANsistlssmsssk 551 greater amberjack
CAG02502     482 YPSSSLLSQALVIADSSSLGTLTSLTAVR 510 spotted green pufferfish
XP_016853691 552 YSHTSRFPSAMVVTDTSGITSLTNMSSSK 580 green anole
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap