Conserved Protein Domain Family
HNF-1_N

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pfam04814: HNF-1_N 
Hepatocyte nuclear factor 1 (HNF-1), N terminus
This family consists of the N terminus of homeobox-containing transcription factor HNF-1. This region contains a dimerization sequence and an acidic region that may be involved in transcription activation. Mutations and the common Ala/Val 98 polymorphism in HNF-1 cause the type 3 form of maturity-onset diabetes of the young (MODY3).
Statistics
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PSSM-Id: 461440
Aligned: 18 rows
Threshold Bit Score: 184.638
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_005169889  13 EQIDLLQRLRRSGMTKQEILHALDTLDRLDREHVEK-FGHRHAH---------GGTSaINHSsNATTSSNSCTTssnnlt 82 
XP_011480690  12 LQQELLSALLDSGVTKDVLIQALDDMDPSPPSFGVKlENLPLSPaapqsgkmnGADP-DSKP-VFHTLTNGHGN------ 83 
XP_016158562   8 LQRELLGALLSSGATKEGLIRALEDMVPA-AGFGVKlESLPLSP---------GGAP-DGRA-ALPALANGHG------- 68 
XP_011910514   8 LQQELLSALLSSGVTKEVLVQALEELLPS-PNFGVKlETLPLSPg-------sGAEP-DTKP-VFHTLTNGHAK------ 71 
XP_006631284  13 EQIDLLQRLRWSGMSKPQILHALESLERLDSEQSHKpPQPRPPC---------YDNHsG-------STFEPTAAasssss 76 
Q1L9E9        38 EQIDLLQRLRLSGMTKPQIIQALESLDRLDPDH-------RTPC---------CNNHsTQP--SAPTSAAPAAPsssss- 98  zebrafish
XP_005450823  43 EQIDLLQRLRLSGMTKPQIIHALESLERLDPEH-------RPSH---------CDSH-PAPSnNAPATAAPAPSssssss 105
CAG05992      39 EQIDLLQRLRLSGMTKPQILHALETLERLDPNH-------RPSR---------CSSQa-----TTPASAPTAAPssssst 97 
XP_015201190  13 EQIDLLQRLRRTGMTKHEILHALDTLDRLDREHGDK-FGRRPAY---------GGGG----GsGTTTTTTTSTNnsnnva 78 
XP_022531856   8 LQQELLSALLDSGLTKDALLRALEDLPPCPQGLGIK-TERPLSP---------VSDC-DSKP-VLLTLGRG--------- 66 
XP_005169889  83 -assstTSTATQtgfrgnGLSPSPSNSYETSPPPtaptsmpvvaplvqngrdalasmsngklspprftvsnvssrafpfe 161
XP_011480690  84 ------KGKLSG------DEGSEDGDDYDTPQIL---------------------------------------------- 105
XP_016158562  69 ------KGKLSG------DEGSEDGDDFDTPQIL---------------------------------------------- 90 
XP_011910514  72 -------GRLSG------DEGSEDGDDYDTPPIL---------------------------------------------- 92 
XP_006631284  77 sslssfTSATTQtqs--laASPSPSNSYEASPPPlypagggq--------------------------------rsfsyd 122
Q1L9E9        99 -sssslTSATTQtpv--idAALSPSNSYDASPPPlyppsgvq--------------------------------rsfsyd 143 zebrafish
XP_005450823 106 asslslASATTQtsg-ldGAALSPSNSFEASPPPlypptvavq-------------------------------rsfsyd 153
CAG05992      98 ssslslASATTQtsg-ldGAALSPSNSYEASPPPlyppsaavq------------------------------rsfsyda 146
XP_015201190  79 -assstTTIATQtq--yrGLSPSPSNSYDTSPPPsaatanqngresmsatpngkl-------spsrytvnsvgarsysfe 148
XP_022531856  67 -------SKVSG------DEASEDGEDRDTPPIL---------------------------------------------- 87 
XP_005169889 162 ppDE--EMDIDD------RVEELMRMDSAIIKEEIKAFLGNRRISQAVVAQVTGISQSRISHWLLqQGSDLSEQKKRAFY 233
XP_011480690 106 --KElqSLNTEEaaeqraEVERMLAEDPWRAARMIKGYMQQHNIPQREVVDITGLNQSHLSQHLN-KGTPMKTQKRAALY 182
XP_016158562  91 --RElqSLNTEEaveqraEVERMISEDPWRAAKMIKGYMQQHNIPQREVVDVTGLNQSHLSQHLN-KGTPMKTQKRAALY 167
XP_011910514  93 --KElqALNTEEaaeqraEVDRMLSEDPWRAAKMIKGYMQQHNIPQREVVDVTGLNQSHLSQHLN-KGTPMKTQKRAALY 169
XP_006631284 123 laEDmgDWDVEE------KVEEYMRRDSNVVKEEIKVFLNNRRISQAIVGQVTGISQSYISQWLLqQGLEMSDPKRRAFY 196
Q1L9E9       144 laEE--DWDLEE------KVEEYMRRDSNLVKEEIKAFLNNRRISQAIVGQVTGISQSYISQWLLqQGLEMSDSKRRAFY 215 zebrafish
XP_005450823 154 mmGEe-DWDLEE------KVEEYMRRDSNLVKEEIKTFLNNRRISQAIVGQVTGISQSYISQWLLqQGLEMSDSKRRAFY 226
CAG05992     147 mgEE--EWDLEE------KVEEYMRRDSNLVKEEIRAFLNNRRISQAIVGQVTGISQSYISQWLLqQGLEMSDSKRRAFY 218
XP_015201190 149 atEE--DLDIDD------KVEELMRRDSSIIKEEIKAFLANRRISQAVVAQVTGISQSRISHWLLqQGSDLSEQKKRAFY 220
XP_022531856  88 --RElqALDTEEaeqqraQVERMLAEDPWRAARTIKSYMQQHNIPQREVVDVTGLNQSHLSQHLN-KGTPMKTTKRAALY 164
XP_005169889 234 RWYQL 238
XP_011480690 183 TWYVR 187
XP_016158562 168 TWYVR 172
XP_011910514 170 TWYVR 174
XP_006631284 197 RWYLL 201
Q1L9E9       216 RWYLL 220 zebrafish
XP_005450823 227 RWYLL 231
CAG05992     219 RWYLL 223
XP_015201190 221 RWYQL 225
XP_022531856 165 TWYAR 169
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