Conserved Protein Domain Family
Synaphin

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pfam05835: Synaphin 
Synaphin protein
This family consists of several eukaryotic synaphin 1 and 2 proteins. Synaphin/complexin is a cytosolic protein that preferentially binds to syntaxin within the SNARE complex. Synaphin promotes SNAREs to form precomplexes that oligomerize into higher order structures. A peptide from the central, syntaxin binding domain of synaphin competitively inhibits these two proteins from interacting and prevents SNARE complexes from oligomerising. It is thought that oligomerization of SNARE complexes into a higher order structure creates a SNARE scaffold for efficient, regulated fusion of synaptic vesicles. Synaphin promotes neuronal exocytosis by promoting interaction between the complementary syntaxin and synaptobrevin transmembrane regions that reside in opposing membranes prior to fusion.
Statistics
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PSSM-Id: 399088
View PSSM: pfam05835
Aligned: 23 rows
Threshold Bit Score: 55.5494
Threshold Setting Gi: 1005961132
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_006639899   1 MSFLLKTMVGSPMKNLSGGggg----gggEEEKKVEgdgketaeskgMTREEFEEYQRQLVEEKIERDKQFAQKKAERAS 76  spotted gar
EFX87986       2 AAFVAKQMLGSKMNAVKGlgg-----ndsEDGDTKD-----------KDDEAERERLEAIKEAEDRRKEKHRKMEVEREN 65  common water flea
BAH72407       2 AAFVAKQVVGNKLNAVKGAvgd-----ggESAEDKE-----------KNAEAERERLEAIREAEERRKEKHRKMEEEREK 65  pea aphid
EFO21969       2 ASFIMKQMVGGKLNEMKGGidkltgdkdgEGGEKTE-------------SGEDPEVVAARLEQEERRKERHRKMEREREK 68  eye worm
EKC20981       2 AAFIAKQMVGNQLKSVKGAigg----gdkEGEGENKed--------aGGGGEDPEVEEMRREAERKRKEKHEKAEAEREE 69  Pacific oyster
XP_009015915   2 vsLLGGGLFGNPLSGVTNAlgd----kdeKDDKNAE--------------EEDPEIAEAKREAEEKRNEKYRKMEEEREA 63  Helobdella robusta
ESN91399       3 A-FLAKQMLGNQLESVKGAlgd----kekEEKKSDD--------------EEDPEILEAKREEEEKRKEKYRKIEEEREK 63  Helobdella robusta
XP_002127457   1 MDFIVKQALGGATKDLNKMmdk----ggeEADPKAE--------------EAQKEQLEAMAEQEAERKAKHTKMEAEREK 62  vase tunicate
P63040         1 MEFVMKQALGGATKDMGKMlgg-----deEKDPDAA--------------KKEEERQEALRQAEEERKAKYAKMEAEREV 61  house mouse
Q6DHG4         1 MNFLLKAAMGGGPPDVGKMlgg-----eeDKDPEAE-------------KEKEEERQEALRQEEEERKAKHAKMEAEREN 62  zebrafish
XP_006639899  77 LRMHMRGKYRLPQSEKDDAQVQIV-----------GGDVDLPEDLAKMVEQDEEEEEANDSLLGKIQNM-ELDFDVIKT 143 spotted gar
EFX87986      66 MRQDIRDKYNIKKKEEAP---EAEtlkep--dnplMRKKKTPEELAKEAEEADQDE------LTKLKNTlETQVNEWKS 133 common water flea
BAH72407      66 MRQEIRDKYNIKKKEELP---EPVqeep---anplMRKKKTPEELAKEAEMEEEDE------FTKLKNTiETQVNELKS 132 pea aphid
EFO21969      69 MRQDIRSKYNIQKKEDGIS--GIPfdtstdgrivgPSMKKTPQQIAQEME-DDDSLIGQLG-LTEQVEKaKTAVNEAle 143 eye worm
EKC20981      70 LRQSIRDKYGLKKKVPEEE--NMMlnndd--ggrvGRKKKTPAELAAEANADSDDDEFT---MPKNMDElKNKVQDIPQ 141 Pacific oyster
XP_009015915  64 MRQTIRDKYHIQKKE------IPKedpgl--egrlGRKKKTPEELAMESDPNYDPSGNN-SVFPKNLDElTSRVKELPN 133 Helobdella robusta
ESN91399      64 MRQDIRTKYNIKKKETNE---PAGndpsl--egrlGRKKKNPEDPDADGTADVSEYENG---FPKTLNElTARVSQLPG 134 Helobdella robusta
XP_002127457  63 ERQRIRDKYGLKRKDEIEAEEKANreret--vgrlGRKQTFEEE---------QEEEEEESVLSQAEKTfSELQQKVTN 130 vase tunicate
P63040        62 MRQGIRDKYGIKKKEEREAEAQAAmeans--egslTRPKK-----AIPPGCGDEPEEEDESILDTVIKYlPGPLQDMFK 133 house mouse
Q6DHG4        63 IRQGIRDKYGIKKREVAEAEEAAAmeqac--egsmTRPKK-----AVPSGCGDDDEEE--NIMDTVMKYlPGPLQDMLK 132 zebrafish
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