Conserved Protein Domain Family
Elongin_A

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pfam06881: Elongin_A 
RNA polymerase II transcription factor SIII (Elongin) subunit A
This family represents a conserved region within RNA polymerase II transcription factor SIII (Elongin) subunit A. In mammals, the Elongin complex activates elongation by RNA polymerase II by suppressing transient pausing of the polymerase at many sites within transcription units. Elongin is a heterotrimer composed of A, B, and C subunits of 110, 18, and 15 kilodaltons, respectively. Subunit A has been shown to function as the transcriptionally active component of Elongin.
Statistics
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PSSM-Id: 462026
Aligned: 100 rows
Threshold Bit Score: 77.6428
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
EGG12725      20 LKDVGNCVYELIRPVLFACPPDQLAEIEDLSPHLM--LE---SDEIWLLHL------RRDFPNESK-PQATrtiepepns 87 
XP_006348930  23 LGDVGETDTHLLERILPHCSLEQLTHVENSTEGRDlsQV---TDRLWKRFY------QIEFGDKSI-NQVVermkk---- 88 
EEF36498      34 LGDVGETDLHLLDQILPHCTMDQLMHVEKSTQGRDlsPI---TDKLWKTFY------EKQFGEREA-NVAIermrr---- 99 
XP_018686693  25 IGDVGEVDLYLLKDILPHCNIDQLTHIEDSTQGRDlsPV---TDALWKRFY------EQQFGVESA-NTVIkrmkq---- 90 
XP_010234349  25 VSSMDGVEMQLLKRILPHCTLDQLTRIESCTE-MDisPA---TDVLWKTFY------QRQFGEDHT-NNVVkkmkq---- 89 
XP_009133550  28 IGYVGGVDFQLLEKILQHCTLEQLMHIEDSTPDTDlsPV---TNELWKRFY------EKQYGAKNL-SFVMekmer---- 93 
NP_001189736  28 IGYVGGVDFQLLEQILQHCTLEQLKHIEDATDDTDlsPI---TDKFWKGFY------KKHYGEEDM-KDLIedlewn--- 94 
EGG20232      17 LKDLNRLNNDLLLRVVQKCSPNQLMSVE---NRLAstGRrldTNELWHKHV------IQTFPNSESmNIFGd-------- 79 
EGC30759     414 IKGLGRIPDKLLIVILDKCPPQQLIAIENKI------GRnvdTEELWKRHCfnlspnQSVSPEDNDvE------------ 475
Q55CM9        30 CKDLGKIPDELLIPILDKCTAQQLATVESRI------GRyvdTEELWKRHChiispeKRHTLKDDE-------------- 89  Dictyostelium d...
EGG12725      88 epyptqtinpytnepidlpIHRIQYFTIKQSKAKALANASARLRERTQANRSEFSKRKA 146
XP_006348930  89 --------------vkvtfKWKQLYEAKTEEMEETQQRSFERIKELYQNENAKRQSRQV 133
EEF36498     100 --------------ykvsfRWKKLYQAKLNEIAKKEDEAVARLRQSYKKEDDKKQSRQI 144
XP_018686693  91 --------------kkivfKWRQLFEAKTKEREEAQNKMGEKLKQRYAETQAKKQSRQI 135
XP_010234349  90 --------------sgvnyQWKDLFNAKTEKQKELEEIMIQRLAKKYQAEKAEKQSKQI 134
XP_009133550  94 --------------skvsfKWRELYEAKLKVVEEDEKEAVDRLKQRYKNEDARKQSRQT 138
NP_001189736  95 --------------kvndfKWRNLYELKVIAVQQKEKELGGRLKERYKDENERKQSRQT 139
EGG20232      80 -------------------SWKQLYADLEKKNQERQLKVGMRLREKYDNSNIEKKSKQI 119
EGC30759     476 -------------------TWRELYVVLERNYLDKARKTGDKLRNTYNNAAKNRQSKQI 515
Q55CM9        90 -------------------SWRDLFTILEREYQNKTKKTGEALRKIYNNAANNKKSKQI 129 Dictyostelium discoideum AX4
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