5AHV,1HX8,3ZYM


Conserved Protein Domain Family
ANTH

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pfam07651: ANTH 
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ANTH domain
AP180 is an endocytotic accessory proteins that has been implicated in the formation of clathrin-coated pits. The domain is involved in phosphatidylinositol 4,5-bisphosphate binding and is a universal adaptor for nucleation of clathrin coats.
Statistics
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PSSM-Id: 400137
Aligned: 28 rows
Threshold Bit Score: 234.886
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
5AHV_F      3 DLQKALKKACSV-EETAPKRKHVRACIVYTWD--HQSSKAVFTTLKTLPLANDEVQLFKMLIVLHKIIQEGHPSALAEAI 79   baker's yeast
KHC72051    7 DLQTSVKKACNA-DEVPPKRKHVRACIVYTWD--HKNSRAFWNAVKIQPLQSNEVQLFKALIMIHKVLQEGHPNTLKDGY 83  
Q9P6L5     16 SLMTSVRKATSI-DETAPKRKHVRSCIIFTWD--HHTARPFWTAIKVQPLLANEVQTFKALITIHRVLQEGHKSALVDSQ 92   Schizosaccharomyc...
Q7SDY1     15 ELAINIRKATSA-EESAPKRKHVRSCIVYTWD--HKSSQSFWAGMKVQPIMADEVQTFKALITIHKVLQEGHPATLREAM 91   Neurospora crassa
Q6CCQ4      9 DLNVNIKKATNT-DESAPKRKHVRACIVYTHD--HRSSKAFWNGIRIQPLQTDDVMVFKALITIHKVLQEGHPSALRDAQ 85   Yarrowia lipolytica
O00291     39 TQTVSINKAINT-QEVAVKEKHARTCILGTHH--EKGAQTFWSVVNRLPLSSNAVLCWKFCHVFHKLLRDGHPNVLKDSL 115  human
O75146     30 TQAISISKAINT-QEAPVKEKHARRIILGTHH--EKGAFTFWSYAIGLPLPSSSILSWKFCHVLHKVLRDGHPNVLHDCQ 106  human
O62142      9 GQFQAVQKAITK-DETPLKPKHLETILLGTHT--EKSSAIFWSSVKKIKLENHPVLTWKFCLLVHKLLRDGHPVVPKEAY 85   Caenorhabditis el...
Q8MQJ8     11 HLNVSVSKALNG-LEAPLKTKHARSIIIMIHK--AKEAKTFWMIISRQPLMQSRFTAWKFSHLLHKVLREGHESAIRHSQ 87   fruit fly
Q9ZVN6     35 TLEVAILKATSHdEEVPIDDRLVTEILGIISSkkSHAASCAAAIGRRIGRTRNWIVALKSLVLVLRIFQDGDPYFPREVL 114  thale cress
5AHV_F     80 RDRDWIRSLGRVHS-------GGSSYSKLIREYVRYLVLKLDFHAHHRGFnn----gtFEYEEYVslv----------sv 138  baker's yeast
KHC72051   84 RNRDFIASLATVFPs------HGSAYGRLINQYDKYILQKLDFHRNNPGFng-----tFEYEEYIslr----------av 142 
Q9P6L5     93 SEKGWLKTCERqyd----gesSPKGYSDLIRDYVDYLLDKLSFHAQHPEFng-----tFEYKEYIslr----------qv 153  Schizosaccharomyc...
Q7SDY1     92 ANRGWIDSLNRGMGg-----eGMRGYGPLIKEYVYYLLAKLSFHQQHPEFng-----tFEYEEYIslk----------ai 151  Neurospora crassa
Q6CCQ4     86 ANVNFIQSLARGNNytg-pnqGNHGYGKLISEYVRFLMQKLTFHKYHPAFng-----mFEYEDYIslr----------tv 149  Yarrowia lipolytica
O00291    116 RYRNELSDMSRMWGh------LSEGYGQLCSIYLKLLRTKMEYHTKNPRFpg-----nLQMSDRQlde----------ag 174  human
O75146    107 RYRSNIREIGDLWGh------LHDRYGQLVNVYTKLLLTKISFHLKHPQFpa-----gLEVTDEVlek---------aag 166  human
O62142     86 RNEKRFTQLALHWK-------DKRDYGPCIDAYCKLLHDRVIFHHKRPYFpg-----nLFVSPLQldt----------mg 143  Caenorhabditis el...
Q8MQJ8     88 SHKKMILEVGKMWGl------LQDDIGCCIQAYSKLLATKLNFHDKNRMFpg-----tLNISFTElfi----------av 146  fruit fly
Q9ZVN6    115 HAMKRGAKILNLSSfrddsnsCPWDFTAFVRTFALYLDERLDCFLTGKLQrrytnreqTGRISTNsttrsrfnpkagiks 194  thale cress
5AHV_F    139 SDPDEGye-tILDLMSLQDSLDEFSQIIFASIQ----SERRN--TECKISALIPLIAESYGIYKFITSMLRAMHRQLNDa 211  baker's yeast
KHC72051  143 NDPNEGye-aLLNLMDLQDSINDLQKLIFATIN-----QSHS--NLCKVSALVPLIAESYGIYKFCISMLRAMYQQLGEd 214 
Q9P6L5    154 DDPNEGye-tVYDMMNLQDHIDEFQKQLFSNFK-----RSNK--NECRIAALVPLVQESYGIYRFLTSMLRALYSTVDAp 225  Schizosaccharomyc...
Q7SDY1    152 NDPNEGye-tITDLMTLQDKIDQFQKLIFSHFRn---VGNN----ECRISALVPLVTESYGIYKFITSMLRAMHSSTGD- 222  Neurospora crassa
Q6CCQ4    150 NDPNEGye-aIMNLMTLQDGVDDFQRLVFSSLQ-----RSRS--NECKISSLVPMIAESYGIYRFVISMLRAMHVSTGN- 220  Yarrowia lipolytica
O00291    175 ESDVNNffqlTVEMFDYLECELNLFQTVFNSLDmsrsVSVTAa-GQCRLAPLIQVILDCSHLYDYTVKLLFKLHSCLPA- 252  human
O75146    167 TDVNNIfq-lTVEMFDYMDCELKLSESVFRQLNtaiaVSQMSs-GQCRLAPLIQVIQDCSHLYHYTVKLLFKLHSCLPA- 243  human
O62142    144 RDLSRMlr-lTGDMMHQMDSLLAFQEKVYLLSNssprWDPNTpqGQCLMLPLISVIMDTWPFFIYIVRMMYNLHSNVSP- 221  Caenorhabditis el...
Q8MQJ8    147 DRDLnycfqlCVEIFDYLEDIIALQLTIFSSMEky-rMSSMTpqGQCRLAPIVCLIQDSNALYDLSVRLMFKLHDGVPY- 224  fruit fly
Q9ZVN6    195 HEPAVR----DMKPVMLLDKITYWQKLLDRAIAtrptGDAKA--NRLVKMSLYAVMQESFDLYRDISDGLALLLDSFFHl 268  thale cress
5AHV_F    212 --eGDAALQPLKERYELQHARLFEFYADCSSVKYLTTLVtIPKLPVDAPDVFLINDVDE 268  baker's yeast
KHC72051  215 -----DALSGLVERFDSQHFMLRDFYTDCHAIKFLTSLItIPRLPNSAPNLKVTDDGqp 268 
Q9P6L5    226 -----ETLEPLKHRYKSQHHRLRQFYADCSNLRYLTSLIsVPRLPHDPPD-LEGDDNIP 278  Schizosaccharomyces pombe 972h-
Q7SDY1    223 ----AEALEPLRGRYDAQHYRLVKFYYECSNLRYLTSLItIPKLPQDPPNLLAEDENAP 277  Neurospora crassa
Q6CCQ4    221 ----DEALESLRQRFYSQHDRLRDFYYDCSTLKYLRSIVtIPQLGKNPPNLLEEEDgpg 275  Yarrowia lipolytica
O00291    253 -----DTLQGHRDRFMEQFTKLKDLFYRSSNLQYFKRLIqIPQLPENPPNFLRASALSE 306  human
O75146    244 -----DTLQGHRDRFHEQFHSLRNFFRRASDMLYFKRLIqIPRLPEGPPNFLRASALAE 297  human
O62142    222 -----HELEGYRSRFQTIFEKTKQFYEECSKHQYFRCFVqIPTFPLHAPNFFTQSDLES 275  Caenorhabditis elegans
Q8MQJ8    225 -----DVVSGHRDRFHGLFLKLKSFYNNVRPLQYFKDLItIPELPDSSPNFKSQNDFTS 278  fruit fly
Q9ZVN6    269 qyqSCINAFQACVRASKQFEELNAFYDLSKSIGIGRTSE-YPSIQKISLELLETLQEFL 326  thale cress
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